NMD-VCellNeuromuscular Virtual Cell Research PlatformEvidence Status · Evidence → perturbation → experiment → outcomeNMD = neuromuscular disorders
For Reviewers Evidence Status Claims

Evidence Release 2026.08DMD context observedDMD candidate-conditioned prediction locked

View scientific status
Evidence freeze: 3 August 2026 P59 hold · scorer failure retained · no target score NAR working package · 6 main + 31 supplementary figures Resource: v1.2.0-measured-dmd-evidence Schema: 1.1 Open platform state → Open Trust Center → Open evidence dashboard → Open claim registry → Open release status →

Evidence Status · canonical public summary

See what is measured, blocked, failed or still missing.

This dashboard compresses the current platform, manuscript and validation state without converting engineering completion into scientific evidence.

Inspect current tracksOpen claim registryOpen platform-state JSONOpen discovery catalog
Two clocks remain explicit. The verified production authority is Sites v193 at commit 61ca4c4c03e5…. This local candidate carries newer truth-repair content and does not become production until a later deployment receipt and anonymous route QA exist.

Current scientific tracks

Technical completion, scientific interpretation and release readiness stay separate.

Inspect publication identities →
HOLD

Science Advances · P59

52/52 archives and 44/44 plate sufficient-statistics outputs completed.

  1. Transport52/52 complete
  2. Plate statistics44/44 complete
  3. Primary scorerFAIL_RETAINED
  4. Target effects · scores · Fig. S3Absent

Claim ceiling: The chemical replay produced no target score. The retained scorer failure is an engineering outcome, not evidence for or against perturbation-transfer performance or DMD efficacy.

Open failure record →
WORKING

NAR resource · curated v08

6 main + 31 supplementary figures; 47 governed members; 15/15 technical checks passed.

  • Technical packagePASS
  • Author reviewRequired
  • DOI/formal metadataOpen
  • Submission-readyNo

Claim ceiling: Working author-review package; technical completeness does not confer formal submission readiness.

Open publication package →
LOCKED

DMD prospective validation

Observed DMD context and computational bridges exist, but the governed candidate set still has no directly measured disease-matched perturbation outcome.

  • Governed candidates21
  • Measured candidate outcomes0
  • Calibrated DMD predictors0
  • Therapeutic claimsNot supported

Next evidence: a preregistered, disease-matched Study → Prediction → Experiment → Outcome event.

Open outcome lifecycle →

Governed discovery

Move from status to the exact current, publication or historical object.

CURRENTstatus
Platform evidence status

One public answer for production identity, evidence freeze, P59, publication packages and the 0/21 DMD outcome boundary.

Object
STATE:PLATFORM:CURRENT
Claim ceiling
Status and governance only; this object does not create a biological result.
Open object →Machine record →
CURRENTclaim registry
Claim registry and evidence graph

Six versioned statements, boundaries and status records linked to their supporting evidence, limiting evidence and downstream consumers.

Object
REGISTRY:CLAIMS:CURRENT
Claim ceiling
Registering six existing statements does not create a new scientific claim; new scientific claim count remains zero.
Open object →Machine record →Evidence graph →Claim diff →
CURRENT LOCAL CANDIDATEresearch answer
Virtual Cell Query Composer 2.0

A source-constrained Research Answer Object that binds one structured DMD/ZNF133 question to eligibility, evidence, domain and OOD state, uncertainty, missing truth, next experiment and claim ceiling.

Object
REGISTRY:RESEARCH_ANSWERS:CURRENT
Claim ceiling
One registered bounded answer and zero new scientific claims; unregistered query combinations abstain without inheriting nearby evidence.
Open object →Machine record →Answer schema →Governing claims →
CURRENT LOCAL CANDIDATEexperiment plan
Experiment OS readiness plan

A machine-checkable projection of the canonical Research Answer and ZNF133 Study Card that separates ready, partial and open execution gates without authorizing an experiment.

Object
REGISTRY:EXPERIMENT_PLANS:CURRENT
Claim ceiling
Design-readiness projection only; execution and registration remain unauthorized while numeric and authority gates are open.
Open object →Machine record →Experiment Plan schema →Outcome Ledger →
CURRENT LOCAL CANDIDATEoutcome ledger
Outcome Ledger

An append-only projection of registered studies, prospective predictions and measured outcomes with explicit zero semantics and governed result states.

Object
REGISTRY:OUTCOME_LEDGER:CURRENT
Claim ceiling
Zero measured outcomes means no governed experiment has returned; it is neither efficacy nor inefficacy evidence.
Open object →Machine record →Outcome Ledger schema →Experiment OS →
CURRENT LOCAL CANDIDATEinformation architecture
Research OS navigation and Trust contract

Seven canonical product destinations plus a five-domain Trust Center and an explicit compatibility ledger for stable legacy routes.

Object
CONTRACT:NAVIGATION:CURRENT
Claim ceiling
Navigation and governance discovery only; this contract creates no scientific claim, model result, experiment authorization or measured outcome.
Open object →Machine record →Evidence status →Claim registry →
CURRENT LOCAL CANDIDATEmodel evaluation contract
Model Evaluation Gateway

One rejection-first contract joining five model adapters, model-run admission, seven metric families and the G0–G7 sparse generalization cube.

Object
CONTRACT:MODEL_EVALUATION:CURRENT
Claim ceiling
Admission and evaluation governance only; zero new runs, zero DMD-calibrated models and zero new scientific claims.
Open object →Machine record →Model Center →Benchmark Suite →
CURRENT LOCAL CANDIDATEdigital tissue contract
Digital Tissue hypothesis workspace

A multiscale evidence map that joins released cell context, physical-time and spatial references to explicit perturbation, cross-cell and patient-calibration gaps.

Object
CONTRACT:DIGITAL_TISSUE:CURRENT
Claim ceiling
Hypothesis and experiment-design layer only; no cell-cell simulation, tissue rescue, patient forecast or new scientific claim.
Open object →Machine record →Cell contexts →Spatial tasks →Experiment OS →
CURRENTrelease
Current platform release manifest

The authoritative resource, schema, evidence-freeze and hosted-object boundary for the live workbench release.

Object
RELEASE:PLATFORM:CURRENT
Claim ceiling
Release identity does not expand scientific claims.
Open object →
CURRENTdirect measurement
Measured DMD context

Correction and external pathway evidence with biological-repeat-aware analyses and an explicit candidate-validation limitation.

Object
EVIDENCE:DMD:MEASURED_CONTEXT
Claim ceiling
Measured disease context; not a measured perturbation outcome for the governed 21 candidates.
Open object →Machine record →
CURRENTcomputational bridge
Candidate decision state

Current action states, blocking gaps and minimum next experiments for the 21 governed hypotheses; no therapeutic rank is generated.

Object
EVIDENCE:CANDIDATE_STATE:CURRENT
Claim ceiling
Hypothesis and next-action support only; directly measured DMD candidate outcomes remain 0/21.
Open object →Machine record →
CURRENTprospective contract
Study and outcome contracts

Draft Study Cards plus prediction and outcome schemas for prospective registration without fabricating a registered study.

Object
CONTRACT:PROSPECTIVE_STUDY:CURRENT
Claim ceiling
Design scaffold only; registered studies, predictions and outcomes remain zero until external events occur.
Open object →Machine record →
CURRENTreproducibility
Portable research snapshot

Checksummed current APIs, tables, code and provenance assembled as a portable RO-Crate source artifact.

Object
REPRO:PORTABLE_RO_CRATE:CURRENT
Claim ceiling
Reproducibility package; not a DOI deposit or independent scientific validation.
Open object →
CURRENT HOLDpublication
Falsification-first evaluation separates failure ranking from utility in perturbation transfer

Current Science Advances manuscript identity. Public scope is status only because the chemical replay produced no target score.

Object
PACKAGE:SCIENCE_ADVANCES:P59
Package state
HOLD PRIMARY SCORER FAILURE
Claim ceiling
The chemical replay produced no target score. The retained scorer failure is an engineering outcome, not evidence for or against perturbation-transfer performance or DMD efficacy.
Open object →Machine record →
CURRENT WORKINGpublication
NMD-VCell NAR curated v08 story-optimized working package

Current public NAR working package with six main figures, 31 supplementary figures and 47 governed members.

Object
PACKAGE:NAR:CURATED_V08_STORY
Package state
WORKING AUTHOR REVIEW REQUIRED NOT SUBMISSION READY
Claim ceiling
Working author-review package; technical completeness does not confer formal submission readiness.
Open object →Machine record →
FROZENpublication
Immutable v1.0.0 database-paper snapshot

Immutable database-paper publication base retained for citation and byte-level provenance.

Object
PACKAGE:DATABASE:V1.0.0
Package state
FROZEN HISTORICAL PUBLICATION BASE
Claim ceiling
This historical package does not define current scientific state.
Open object →Machine record →
SUPERSEDEDpublication
Science Advances v09.80 review packet

Earlier Science Advances review packet retained as history and explicitly superseded by P59.

Object
PACKAGE:SCIENCE_ADVANCES:V09.80
Package state
HISTORICAL SUPERSEDED BY P59
Claim ceiling
This historical package does not define current scientific state.
Open object →
HISTORICALaudit
Historical download ledger

The complete versioned-file and checksum ledger for auditors who need older or internal release identities.

Object
ARCHIVE:DOWNLOAD_AUDIT
Claim ceiling
Provenance and recovery only; directory presence is not current-package membership.
Open object →

Interpretation boundary

PASS means the named gate passed—not that every downstream claim is true.

Engineering: transport, parsing and package checks can pass while scoring fails.

Science: missing outcomes require abstention rather than a favorable or unfavorable result.

Publication: technical completeness does not equal author approval, DOI deposit or submission readiness.