NMD-VCellNeuromuscular Virtual Cell Research PlatformClaim Registry · Evidence → perturbation → experiment → outcomeNMD = neuromuscular disorders
For Reviewers Evidence Status Claims

Evidence Release 2026.08DMD context observedDMD candidate-conditioned prediction locked

View scientific status
Evidence freeze: 3 August 2026 P59 hold · scorer failure retained · no target score NAR working package · 6 main + 31 supplementary figures Resource: v1.2.0-measured-dmd-evidence Schema: 1.1 Open platform state → Open Trust Center → Open evidence dashboard → Open claim registry → Open release status →

Claim Registry · local V201 candidate

Trace every current claim to evidence, limits and downstream use.

A Claim Object is not a prose highlight. It is a versioned statement with subjects, evidence state, claim ceiling, negative implications, next-evidence condition and a content digest.

Inspect claim objectsOpen registry JSONOpen JSON SchemaOpen answer composer
6 claim objects · 0 new scientific claims. V196 encoded the Claim layer; V197 consumed it in a bounded Research Answer; V198 projected execution gates and an empty Outcome Ledger; V199 unified navigation and Trust; V200 closed model-evaluation routing; V201 adds a bounded Digital Tissue hypothesis map. None adds evidence, changes the frozen scientific release or promotes this local candidate to production.

Versioned Claim Objects

Filter the statements before following their evidence.

Evidence state says what kind of support exists. Claim ceiling says how far the statement may travel. “Does not imply” blocks common cross-layer overinterpretations.

Open checksummed registry →

MISSINGEVIDENCE BOUNDARY

DMD candidate outcome boundary

The 21 governed DMD candidates have 0 directly measured disease-matched perturbation outcomes.

Claim ID
CLAIM:DMD:CANDIDATE_OUTCOME_BOUNDARY:V1
Subjects
DISEASE:DMD · CANDIDATE_SET:DMD:21
Claim ceiling
This is an evidence-availability statement. It supports abstention and next-experiment planning, not efficacy or inefficacy.
Does not imply
candidate efficacy · candidate inefficacy · therapeutic ranking · clinical recommendation
Next evidence
A preregistered disease-matched perturbation study with independent biological units, matched controls, target engagement and a functional outcome.
Machine object →RECORDS ABSENCE →RECORDS ABSENCE →
OBSERVED ENGINEERINGENGINEERING STATUS

P59 transport and plate-statistics completion

GSE306429 completed transport for 52/52 authorized archives and fixed plate sufficient-statistics for 44/44 primary archives.

Claim ID
CLAIM:P59:TRANSPORT_AND_PLATES_COMPLETE:V1
Subjects
DATASET:GSE306429 · PUBLICATION_PACKAGE:PUB:SCIENCE_ADVANCES:P59:20260911
Claim ceiling
Transport and plate-statistics completion are engineering observations; they do not establish successful target scoring or perturbation-transfer performance.
Does not imply
successful target scoring · model performance · DMD efficacy
Next evidence
A governed scorer execution that either produces a valid target-score object or retains a new failure receipt.
Machine object →SUPPORTS →LIMITS →
FAILURE RETAINEDENGINEERING STATUS

P59 primary scorer failure

The GSE306429 primary scorer failed before target effects or target scores were created because object arrays could not be loaded with allow_pickle=False.

Claim ID
CLAIM:P59:PRIMARY_SCORER_FAILURE:V1
Subjects
DATASET:GSE306429 · PROCESS:P59:PRIMARY_SCORER
Claim ceiling
A retained engineering failure is evidence about execution state, not evidence for or against biological transfer performance.
Does not imply
poor model performance · successful model performance · candidate efficacy · candidate inefficacy
Next evidence
Execute the predeclared metadata-only repair under a superseding receipt while preserving numeric arrays, axes, genes, routes, items and thresholds.
Machine object →RECORDS FAILURE →LIMITS →
MISSINGMISSING RESULT

P59 target result remains absent

No GSE306429 target-effect table, target-score object or target-result Figure S3 exists in the P59 state.

Claim ID
CLAIM:P59:NO_TARGET_SCORE:V1
Subjects
DATASET:GSE306429 · RESULT:P59:TARGET_SCORE · FIGURE:P59:S3
Claim ceiling
Absence of the target result requires abstention. It is neither a null result nor a negative performance finding.
Does not imply
null biological effect · negative transfer performance · positive transfer performance · completed Figure S3
Next evidence
A successful governed primary-scorer output with checksummed target effects, scores and a separately generated figure.
Machine object →RECORDS ABSENCE →
BOUNDED INTERPRETATIONBOUNDED SCIENTIFIC INTERPRETATION

Failure ranking and utility remain distinct

Within the fixed historical evidence base, failure ranking and utility are treated as distinct endpoints; the strict evidence base remains three study-level groups and P59 adds zero independent groups.

Claim ID
CLAIM:SUPPORT_AWARE:RANKING_UTILITY_SEPARATION:V1
Subjects
RESEARCH_PROGRAM:SUPPORT_AWARE_TRANSFER · PUBLICATION_PACKAGE:PUB:SCIENCE_ADVANCES:P59:20260911
Claim ceiling
This is a bounded interpretation of fixed historical replays. P59 does not add a target score, an independent study group or DMD functional evidence.
Does not imply
generalized perturbation-transfer performance · prospective validation · DMD efficacy
Next evidence
Independent predeclared replication with separated custody and a successfully scored target outcome.
Machine object →SUPPORTS →LIMITS →
WORKINGPUBLICATION STATUS

NAR curated v08 working-package state

The current NAR curated v08 working package has 6 main figures, 31 supplementary figures, 47 governed members and 15/15 technical checks passed, but it is not submission-ready.

Claim ID
CLAIM:NAR:CURATED_V08_WORKING_STATE:V1
Subjects
PUBLICATION_PACKAGE:PUB:NAR:CURATED_V08_STORY:20260818
Claim ceiling
Technical completeness and package membership do not confer author approval, DOI deposit or formal submission readiness.
Does not imply
author approval · formal submission readiness · DOI deposit · new scientific evidence
Next evidence
Author review, final scientific approval and external submission/deposit receipts.
Machine object →DEFINES MEMBERSHIP →LIMITS →

Typed Evidence Graph

Claim → evidence role → consumer.

Each lane makes direction and relation type explicit. A supporting object can establish an engineering fact while a limiting object constrains the scientific interpretation.

Open graph JSON →

Claim Diff · production → local

One engineering status changed; the scientific boundary did not.

PRODUCTION:SITES:V193 → LOCAL:RESEARCH_OS:V201

Status transitionProduction baseline: active authorized transfer → local FAIL_RETAINED, no target score

Transport and plate statistics completed, then the primary scorer failed before target effects or scores.

Unchanged science0/21 DMD outcomes · strict groups 3 · increment 0

No therapeutic claim, target score or Figure S3 was created.

Interface delta6 registered claim records

New scientific claims: 0. Retired scientific claims: 0.

Open machine-readable Claim Diff →

Interpretation contract

Evidence links qualify a statement; they do not erase its ceiling.

Missing: requires abstention, not a null or unfavorable result.

Failure retained: describes execution state, not model or biological performance.

Working: describes publication assembly, not submission readiness.