NMD-VCell Virtual Cell Evidence Engine See what is known, what is uncertain, and what to test next Module: Validate / registry · evidence-to-experiment workflow NMD = neuromuscular disorders

Current limit: the site can compare existing evidence, but no candidate has yet been independently repeated in a DMD muscle model.

Research evidence only 21 observed HepG2 perturbations 0 independent DMD replications Boundary & release
Observed HepG2 perturbations with limited external myogenic context No validated DMD perturbation prediction v1.0.0-database-resource Frozen 25 Jul 2026 Schema 1.1 Model ridge-safe-v2.3 Benchmark repeated-fold-v2.2 Build EA-20260730-29 DOI pending Open evidence boundary →

Model capability map

See which engines exist, which failed transfer, and which have not been built.

Model status is reported as a scientific result—not hidden behind a generic “AI” label.

Model 1

Same-context perturbation baseline

Available · limited

Current basis: Trained and evaluated inside the processed HepG2 response dataset.

Result: Small average-error improvement; response direction is not reliable.

Model 2

External perturbation transfer

Tested · unsupported

Current basis: Evaluated on a 55-target external aggregate diagnostic.

Result: The current model did not transfer directionally.

Model 3

DMD muscle response model

Not trained

Current basis: Requires independent DMD and matched-control perturbation outcomes.

Result: No calibrated DMD prediction is emitted.

Model 4

Patient digital twin

Not available

Current basis: Requires longitudinal patient-linked state, intervention and outcome data.

Result: No patient-specific trajectory or treatment simulation is permitted.

Open benchmark resultsSee the development program