NMD-VCell Evidence & Experiment Workbench Audit DMD evidence, compare gaps, and freeze the missing test Module: Documentation · evidence-to-experiment workflow NMD = neuromuscular disorders

Current limit: the site can compare existing evidence, but no candidate has yet been independently repeated in a DMD muscle model.

Research evidence only 21 prioritized candidate perturbation records 2,160 benchmark perturbation targets 250 observed human-myoblast fusion hits Prospective DMD candidate validation pending Boundary & release
21 Workbench candidates are surfaced for consideration, not ranked as validated targets 2,160 target-level perturbation responses form the frozen HepG2 benchmark substrate GSE293514 Stage B0 contributes 250 healthy-human-myoblast fusion hits and 125 individually validated genes No validated DMD perturbation prediction v1.2.0-measured-dmd-evidence Frozen 3 August 2026 Schema 1.1 Model ridge-safe-v2.3 Benchmark repeated-fold-v2.2 Build EA-20260804-49 DOI pending Open evidence boundary →

Immutable publication snapshot

v1.0.0-database-resource

The database-paper evidence surface is frozen at build EA-20260802-46. Later Stage C1 pathway work belongs to a successor release and does not rewrite this object.

The frozen RO-Crate filename, byte count and SHA-256 remain registered below and in source history; the historical ZIP is excluded from direct Sites hosting.

Scientific boundary: This frozen database-paper snapshot contains the Stage B0 observed healthy-myoblast network. It contains no candidate-level DMD perturbation truth, no validated DMD pathway prediction and no therapeutic claim.

Checksum-locked objects

The manuscript and frozen files point to the same bytes.

Publication bundle

BUNDLE:DATABASE_V1:STAGE5_44

Composite database-v1 identity

b435f2100badd88e81dae1afa47bff278ba97d56d84df6d5d4dd6c3d4096b256

Workbench overlay

FILE:OVERLAY:v1.0.0-database-resource:stage5.88:20260802

3,178,743 bytes

04c982d002b3ab0ad44319d6327116086da3a87a182430e4d475a1e2ad60b2e1

Portable RO-Crate

nmd-vcell-v1.0.0-ro-crate.zip

24,512,546 bytes

17610896790b76d715300a1edbe1d6ee5cb573bceb9691d1b031136c7f40e9e8

Successor relationship

The live workbench can advance without changing the cited study.

The default site now reports v1.2.0-measured-dmd-evidence and EA-20260804-49. Stage C1 candidate cascades and Stage C2 measured DMD context are successor analyses; neither changes the frozen v1.0 bytes nor creates candidate-level DMD response truth.