NMD-VCell Neuromuscular Virtual Cell Research Platform Module: Data · Evidence → perturbation → experiment → outcome NMD = neuromuscular disorders
For Reviewers Current Release
Science & reproducibility
Advanced workspace Current release Scientific program Methods & reproducibility Evidence governance Evidence freeze: 3 August 2026
Available nowExplore disease contextInspect gene evidenceAudit model runsDesign experimentsProspective DMD outcome is nextCheck computability
Evidence Release 2026.08 Measured DMD context Truth-generation study is the next milestone Prediction validation follows model eligibility Archive identity awaiting external authorization Release status →
Evidence details 21 governed candidate records 2,160 benchmark perturbation targets 250 observed human-myoblast fusion hits Expand
21 prespecified hypotheses are governed records; no current target ranking is generated 2,160 target-level perturbation responses form the frozen HepG2 benchmark substrate GSE293514 Stage B0 contributes 250 healthy-human-myoblast fusion hits and 125 individually validated genes Measured DMD disease context is available; direct candidate-level DMD perturbation outcomes are not yet available v1.2.0-measured-dmd-evidence Frozen 3 August 2026 Schema 1.1 Model ridge-safe-v2.3 Benchmark repeated-fold-v2.2 Build EA-20260817-57 DOI pending Evidence boundary → Full audit view →

Immutable publication snapshot

v1.0.0-database-resource

The database-paper evidence surface is frozen at build EA-20260802-46. Later Stage C1 pathway work belongs to a successor release and does not rewrite this object.

Download frozen overlay RO-Crate only · open manifestOpen base manifestOpen snapshot record

The frozen RO-Crate filename, byte count and SHA-256 remain registered below and in source history; the historical ZIP is excluded from direct Sites hosting.

Scientific boundary: This frozen database-paper snapshot contains the Stage B0 observed healthy-myoblast network. It contains no candidate-level DMD perturbation outcome, no validated DMD pathway prediction and no therapeutic claim.

NAR review mode

Verify the frozen database in four bounded steps.

This path excludes successor analyses and takes a first-time reviewer from release identity to a real query, observed network and downloadable objects.

Download quickstart → RO-Crate only · open manifest
01 · Representative queryReplay ZNF133 against the frozen objectInspect source context, disagreement, explicit no-edge status and the next evidence gap without generating a rank. 02 · Observed networkInspect typed healthy-myoblast edgesConfirm that measured source-study edges are not relabelled as DMD predictions. 03 · Evidence-to-experiment tableReview all 21 governed candidate statesActions and blocking gaps remain separate from historical score sensitivity. 04 · Release manifestVerify identity, files and checksumsThe frozen publication object remains distinct from the live successor.

Checksum-locked objects

The manuscript and frozen files point to the same bytes.

Publication bundle

BUNDLE:DATABASE_V1:STAGE5_44

Composite database-v1 identity

b435f2100badd88e81dae1afa47bff278ba97d56d84df6d5d4dd6c3d4096b256

Workbench overlay

FILE:OVERLAY:v1.0.0-database-resource:stage5.88:20260802

3,178,743 bytes

04c982d002b3ab0ad44319d6327116086da3a87a182430e4d475a1e2ad60b2e1

Portable RO-Crate

nmd-vcell-v1.0.0-ro-crate.zip

24,512,546 bytes

17610896790b76d715300a1edbe1d6ee5cb573bceb9691d1b031136c7f40e9e8

Successor relationship

The live workbench can advance without changing the cited study.

The default site now reports v1.2.0-measured-dmd-evidence and EA-20260817-57. Stage C1 candidate cascades and Stage C2 measured DMD context are successor analyses; neither changes the frozen v1.0 bytes nor creates candidate-level DMD response outcome.

Current releaseStage C1 cascadeStage C2 evidencev1 deposit candidate