gene	current_action	current_action_label	research_question	practical_use	decision_available_now	decision_blocking_gap	minimum_next_action	supportive_result	null_result	inconclusive_or_qc_failure	evidence_tier	prediction_readiness	dmd_source_state	muscle_tpm	external_screen_state
CPEB1	verify_expression	Verify expression	Is CPEB1 detectably expressed at RNA and protein level in the intended human muscle model?	Use this candidate to decide whether a perturbation experiment would be technically interpretable.	Expression feasibility must be resolved before perturbation resources are committed.	GAP-06: Expression feasibility is not verified in the intended model	Measure CPEB1 RNA and, where a validated reagent exists, protein in the intended myoblast or myotube state.	If the predeclared detectability threshold is met in independent biological replicates, move to a bounded perturbation design.	If the target stays below the frozen detectability threshold, stop or redesign the assay; this is a feasibility result, not evidence of no biological role.	If RNA and protein or biological replicates disagree, retain the expression gate and resolve assay specificity or state dependence.	G3	R1	conflicted	0.731389	not_assessed
DNAAF3	verify_expression	Verify expression	Is DNAAF3 detectably expressed at RNA and protein level in the intended human muscle model?	Use this candidate to decide whether a perturbation experiment would be technically interpretable.	Expression feasibility must be resolved before perturbation resources are committed.	GAP-06: Expression feasibility is not verified in the intended model	Measure DNAAF3 RNA and, where a validated reagent exists, protein in the intended myoblast or myotube state.	If the predeclared detectability threshold is met in independent biological replicates, move to a bounded perturbation design.	If the target stays below the frozen detectability threshold, stop or redesign the assay; this is a feasibility result, not evidence of no biological role.	If RNA and protein or biological replicates disagree, retain the expression gate and resolve assay specificity or state dependence.	G3	R1	consistent_up	0.0755557	not_assessed
EPS8L1	verify_expression	Verify expression	Is EPS8L1 detectably expressed at RNA and protein level in the intended human muscle model?	Use this candidate to decide whether a perturbation experiment would be technically interpretable.	Expression feasibility must be resolved before perturbation resources are committed.	GAP-06: Expression feasibility is not verified in the intended model	Measure EPS8L1 RNA and, where a validated reagent exists, protein in the intended myoblast or myotube state.	If the predeclared detectability threshold is met in independent biological replicates, move to a bounded perturbation design.	If the target stays below the frozen detectability threshold, stop or redesign the assay; this is a feasibility result, not evidence of no biological role.	If RNA and protein or biological replicates disagree, retain the expression gate and resolve assay specificity or state dependence.	G3	R1	consistent_up	0.236384	not_assessed
ZFP69B	verify_expression	Verify expression	Is ZFP69B detectably expressed at RNA and protein level in the intended human muscle model?	Use this candidate to decide whether a perturbation experiment would be technically interpretable.	Expression feasibility must be resolved before perturbation resources are committed.	GAP-06: Expression feasibility is not verified in the intended model	Measure ZFP69B RNA and, where a validated reagent exists, protein in the intended myoblast or myotube state.	If the predeclared detectability threshold is met in independent biological replicates, move to a bounded perturbation design.	If the target stays below the frozen detectability threshold, stop or redesign the assay; this is a feasibility result, not evidence of no biological role.	If RNA and protein or biological replicates disagree, retain the expression gate and resolve assay specificity or state dependence.	G3	R1	conflicted	0.155208	not_assessed
INTS13	risk_review	Risk/context review	Does INTS13 have a dependency, toxicity or context-specific safety profile that blocks escalation?	Use this candidate to decide whether a usable perturbation window exists before testing disease relevance.	Safety and dependency context require review before a larger perturbation experiment.	GAP-08: Safety and dependency context blocks escalation	Run a context-matched dose/time and viability review for INTS13 with engagement, toxicity and stop rules declared in advance.	If a reproducible perturbation window meets engagement and viability gates across biological units, advance to a functional muscle assay.	If no acceptable window remains after engagement and QC, stop escalation and retain the negative feasibility evidence.	If the window is donor-, dose- or reagent-specific, classify the result as context dependent and redesign before escalation.	G3	R1	consistent_up	10.9911	not_assessed
NAGLU	risk_review	Risk/context review	Does NAGLU have a dependency, toxicity or context-specific safety profile that blocks escalation?	Use this candidate to decide whether a usable perturbation window exists before testing disease relevance.	Safety and dependency context require review before a larger perturbation experiment.	GAP-08: Safety and dependency context blocks escalation	Run a context-matched dose/time and viability review for NAGLU with engagement, toxicity and stop rules declared in advance.	If a reproducible perturbation window meets engagement and viability gates across biological units, advance to a functional muscle assay.	If no acceptable window remains after engagement and QC, stop escalation and retain the negative feasibility evidence.	If the window is donor-, dose- or reagent-specific, classify the result as context dependent and redesign before escalation.	G4	R2	conflicted	8.66362	assessed
RAC3	risk_review	Risk/context review	Does RAC3 have a dependency, toxicity or context-specific safety profile that blocks escalation?	Use this candidate to decide whether a usable perturbation window exists before testing disease relevance.	Safety and dependency context require review before a larger perturbation experiment.	GAP-08: Safety and dependency context blocks escalation	Run a context-matched dose/time and viability review for RAC3 with engagement, toxicity and stop rules declared in advance.	If a reproducible perturbation window meets engagement and viability gates across biological units, advance to a functional muscle assay.	If no acceptable window remains after engagement and QC, stop escalation and retain the negative feasibility evidence.	If the window is donor-, dose- or reagent-specific, classify the result as context dependent and redesign before escalation.	G3	R1	conflicted	0.339463	not_assessed
RNASEH2C	risk_review	Risk/context review	Does RNASEH2C have a dependency, toxicity or context-specific safety profile that blocks escalation?	Use this candidate to decide whether a usable perturbation window exists before testing disease relevance.	Safety and dependency context require review before a larger perturbation experiment.	GAP-08: Safety and dependency context blocks escalation	Run a context-matched dose/time and viability review for RNASEH2C with engagement, toxicity and stop rules declared in advance.	If a reproducible perturbation window meets engagement and viability gates across biological units, advance to a functional muscle assay.	If no acceptable window remains after engagement and QC, stop escalation and retain the negative feasibility evidence.	If the window is donor-, dose- or reagent-specific, classify the result as context dependent and redesign before escalation.	G4	R2	consistent_up	9.52581	assessed
RNF8	risk_review	Risk/context review	Does RNF8 have a dependency, toxicity or context-specific safety profile that blocks escalation?	Use this candidate to decide whether a usable perturbation window exists before testing disease relevance.	Safety and dependency context require review before a larger perturbation experiment.	GAP-08: Safety and dependency context blocks escalation	Run a context-matched dose/time and viability review for RNF8 with engagement, toxicity and stop rules declared in advance.	If a reproducible perturbation window meets engagement and viability gates across biological units, advance to a functional muscle assay.	If no acceptable window remains after engagement and QC, stop escalation and retain the negative feasibility evidence.	If the window is donor-, dose- or reagent-specific, classify the result as context dependent and redesign before escalation.	G3	R1	conflicted	4.10534	not_assessed
WDR4	risk_review	Risk/context review	Does WDR4 have a dependency, toxicity or context-specific safety profile that blocks escalation?	Use this candidate to decide whether a usable perturbation window exists before testing disease relevance.	Safety and dependency context require review before a larger perturbation experiment.	GAP-08: Safety and dependency context blocks escalation	Run a context-matched dose/time and viability review for WDR4 with engagement, toxicity and stop rules declared in advance.	If a reproducible perturbation window meets engagement and viability gates across biological units, advance to a functional muscle assay.	If no acceptable window remains after engagement and QC, stop escalation and retain the negative feasibility evidence.	If the window is donor-, dose- or reagent-specific, classify the result as context dependent and redesign before escalation.	G4	R2	consistent_up	4.15911	assessed
ZNF236	risk_review	Risk/context review	Does ZNF236 have a dependency, toxicity or context-specific safety profile that blocks escalation?	Use this candidate to decide whether a usable perturbation window exists before testing disease relevance.	Safety and dependency context require review before a larger perturbation experiment.	GAP-08: Safety and dependency context blocks escalation	Run a context-matched dose/time and viability review for ZNF236 with engagement, toxicity and stop rules declared in advance.	If a reproducible perturbation window meets engagement and viability gates across biological units, advance to a functional muscle assay.	If no acceptable window remains after engagement and QC, stop escalation and retain the negative feasibility evidence.	If the window is donor-, dose- or reagent-specific, classify the result as context dependent and redesign before escalation.	G3	R1	conflicted	2.00686	not_assessed
MON1A	muscle_assay	Muscle-context assay	Does the MON1A response observed outside muscle transfer to a controlled human myogenic system?	Use this candidate to test context transfer and decide whether a matched DMD/control study is justified.	Eligible for a preregistered human-myogenic feasibility experiment; not established as a therapeutic target.	GAP-02: Independent muscle-context perturbation is absent	Perturb MON1A with at least two independent reagents in a declared human myogenic state and freeze one functional primary endpoint.	If engagement and QC pass, both reagents agree, and the primary phenotype replicates beyond one biological unit, advance to matched DMD/control validation.	If engagement and QC pass but the primary phenotype is null, record a null muscle-context outcome and stop treating the non-muscle response as transferable.	If reagents, donors or batches disagree, classify the result as inconclusive and resolve heterogeneity before any escalation.	G4	R2	conflicted	8.05698	assessed
ZNF133	muscle_assay	Muscle-context assay	Does the ZNF133 response observed outside muscle transfer to a controlled human myogenic system?	Use this candidate to test context transfer and decide whether a matched DMD/control study is justified.	Eligible for a preregistered human-myogenic feasibility experiment; not established as a therapeutic target.	GAP-02: Independent muscle-context perturbation is absent	Perturb ZNF133 with at least two independent reagents in a declared human myogenic state and freeze one functional primary endpoint.	If engagement and QC pass, both reagents agree, and the primary phenotype replicates beyond one biological unit, advance to matched DMD/control validation.	If engagement and QC pass but the primary phenotype is null, record a null muscle-context outcome and stop treating the non-muscle response as transferable.	If reagents, donors or batches disagree, classify the result as inconclusive and resolve heterogeneity before any escalation.	G4	R2	conflicted	4.55781	assessed
ADAM10	computational_replication	Computational replication	Does the ADAM10 evidence pattern survive an independent dataset and frozen analysis workflow?	Use this candidate to decide whether the current computational signal is reproducible enough to justify experimental escalation.	Experimental escalation remains provisional until the signal is independently reproduced.	GAP-07: Independent computational replication is absent	Repeat the ADAM10 analysis in an independent dataset with frozen mapping, contrasts, baselines, null controls and uncertainty reporting.	If direction and uncertainty reproduce under the frozen plan, retain the candidate and move to its next context-specific gate.	If the signal does not reproduce despite adequate coverage and QC, retain the negative result and do not escalate from the original analysis alone.	If coverage, mapping or source design prevents a fair comparison, mark the replication non-evaluable rather than positive or negative.	G4	R2	conflicted	3.1162	assessed
CALR	computational_replication	Computational replication	Does the CALR evidence pattern survive an independent dataset and frozen analysis workflow?	Use this candidate to decide whether the current computational signal is reproducible enough to justify experimental escalation.	Experimental escalation remains provisional until the signal is independently reproduced.	GAP-07: Independent computational replication is absent	Repeat the CALR analysis in an independent dataset with frozen mapping, contrasts, baselines, null controls and uncertainty reporting.	If direction and uncertainty reproduce under the frozen plan, retain the candidate and move to its next context-specific gate.	If the signal does not reproduce despite adequate coverage and QC, retain the negative result and do not escalate from the original analysis alone.	If coverage, mapping or source design prevents a fair comparison, mark the replication non-evaluable rather than positive or negative.	G4	R2	conflicted	88.6307	assessed
DDX19B	computational_replication	Computational replication	Does the DDX19B evidence pattern survive an independent dataset and frozen analysis workflow?	Use this candidate to decide whether the current computational signal is reproducible enough to justify experimental escalation.	Experimental escalation remains provisional until the signal is independently reproduced.	GAP-07: Independent computational replication is absent	Repeat the DDX19B analysis in an independent dataset with frozen mapping, contrasts, baselines, null controls and uncertainty reporting.	If direction and uncertainty reproduce under the frozen plan, retain the candidate and move to its next context-specific gate.	If the signal does not reproduce despite adequate coverage and QC, retain the negative result and do not escalate from the original analysis alone.	If coverage, mapping or source design prevents a fair comparison, mark the replication non-evaluable rather than positive or negative.	G4	R2	conflicted	7.22865	assessed
DNM1	computational_replication	Computational replication	Does the DNM1 evidence pattern survive an independent dataset and frozen analysis workflow?	Use this candidate to decide whether the current computational signal is reproducible enough to justify experimental escalation.	Experimental escalation remains provisional until the signal is independently reproduced.	GAP-07: Independent computational replication is absent	Repeat the DNM1 analysis in an independent dataset with frozen mapping, contrasts, baselines, null controls and uncertainty reporting.	If direction and uncertainty reproduce under the frozen plan, retain the candidate and move to its next context-specific gate.	If the signal does not reproduce despite adequate coverage and QC, retain the negative result and do not escalate from the original analysis alone.	If coverage, mapping or source design prevents a fair comparison, mark the replication non-evaluable rather than positive or negative.	G3	R1	conflicted	1.39988	not_assessed
EHMT2	computational_replication	Computational replication	Does the EHMT2 evidence pattern survive an independent dataset and frozen analysis workflow?	Use this candidate to decide whether the current computational signal is reproducible enough to justify experimental escalation.	Experimental escalation remains provisional until the signal is independently reproduced.	GAP-07: Independent computational replication is absent	Repeat the EHMT2 analysis in an independent dataset with frozen mapping, contrasts, baselines, null controls and uncertainty reporting.	If direction and uncertainty reproduce under the frozen plan, retain the candidate and move to its next context-specific gate.	If the signal does not reproduce despite adequate coverage and QC, retain the negative result and do not escalate from the original analysis alone.	If coverage, mapping or source design prevents a fair comparison, mark the replication non-evaluable rather than positive or negative.	G3	R1	conflicted	6.40587	not_assessed
LMO2	computational_replication	Computational replication	Does the LMO2 evidence pattern survive an independent dataset and frozen analysis workflow?	Use this candidate to decide whether the current computational signal is reproducible enough to justify experimental escalation.	Experimental escalation remains provisional until the signal is independently reproduced.	GAP-07: Independent computational replication is absent	Repeat the LMO2 analysis in an independent dataset with frozen mapping, contrasts, baselines, null controls and uncertainty reporting.	If direction and uncertainty reproduce under the frozen plan, retain the candidate and move to its next context-specific gate.	If the signal does not reproduce despite adequate coverage and QC, retain the negative result and do not escalate from the original analysis alone.	If coverage, mapping or source design prevents a fair comparison, mark the replication non-evaluable rather than positive or negative.	G3	R1	conflicted	15.237	not_assessed
MPHOSPH6	computational_replication	Computational replication	Does the MPHOSPH6 evidence pattern survive an independent dataset and frozen analysis workflow?	Use this candidate to decide whether the current computational signal is reproducible enough to justify experimental escalation.	Experimental escalation remains provisional until the signal is independently reproduced.	GAP-07: Independent computational replication is absent	Repeat the MPHOSPH6 analysis in an independent dataset with frozen mapping, contrasts, baselines, null controls and uncertainty reporting.	If direction and uncertainty reproduce under the frozen plan, retain the candidate and move to its next context-specific gate.	If the signal does not reproduce despite adequate coverage and QC, retain the negative result and do not escalate from the original analysis alone.	If coverage, mapping or source design prevents a fair comparison, mark the replication non-evaluable rather than positive or negative.	G4	R2	consistent_up	4.94586	assessed
GFOD2	hold_pending_external_audit	Provisional hold · external report not yet audited	Can the reported external GFOD2 evidence be reproduced from traceable quantitative data and provenance?	Use this candidate to decide whether an external report is strong enough to change the governed evidence state.	Keep the current status unchanged until the external result is imported and audited.	GAP-09: External quantitative evidence has not been imported and audited	Import the GFOD2 effect estimates, denominators, analysis rules and provenance, then reproduce the reported conclusion.	If the quantitative result and provenance reproduce, reassign the candidate through the normal evidence-transition rules.	If the report cannot be reproduced or supported by its source data, keep the hold and retain the failed audit as evidence.	If essential files or metadata are unavailable, keep the report unassessed and do not translate absence into a negative biological result.	G3	R1	conflicted	2.94732	not_assessed