9 observed or measured; 0 candidate-conditioned DMD outcomes.
Digital Tissue · local V201 candidate
Map tissue-scale evidence without pretending to simulate it.
Released cell-context, physical-time and spatial-reference objects now share one multiscale evidence map. Every unsupported jump—from perturbation to neighboring cells, tissue function or patient trajectory—remains visibly locked.
Available reference substrate
Three bounded views are available; none is a perturbation-conditioned tissue truth.
Counts below resolve from released context, trajectory and spatial-task objects. Statistical units and transfer limits remain attached to their sources.
GSE52529 at 0 / 24 / 48 / 72 h; unperturbed human myoblast reference only.
two mdx strain backgrounds; not DMD versus wild type Random feature-dropout stability does not establish gene-panel transfer.
Evidence planes
Three bounded references; three missing or locked planes.
Each plane declares its permitted use and boundary. Visual adjacency never creates a causal or simulated interaction.
CELL_CONTEXTBOUNDED OBSERVED CONTEXT
Disease and cell context
Inspect measured or explicitly missing disease/cell contexts with their statistical units.
Context proximity is descriptive and does not create a candidate-conditioned response.PHYSICAL_TIMEMEASURED REFERENCE ONLY
Physical-time myogenic reference
Inspect the unperturbed human myoblast reference at physical sampling times.
This is not a longitudinal DMD trajectory or perturbation-conditioned fate.SPATIAL_REFERENCEBOUNDED SPATIAL REFERENCE
Spatial tissue representation
Inspect registered section-level representation stability and its sensitivity requirements.
The released mdx comparison lacks a wild-type arm and confirmed animal-level identity; nonspatial objects cannot enter the spatial task.DMD_PERTURBATIONMISSING REQUIRED OUTCOME
Candidate-conditioned DMD response
Expose the missing truth and route users to a governed experiment plan.
Zero measured candidate outcomes is absence of evidence, not a null or negative effect.CROSS_CELL_OUTCOMELOCKED NO MATCHED CROSS CELL TRUTH
Cross-cell and tissue outcome
Form a falsifiable multicellular hypothesis only.
No matched perturbation, neighboring-cell response and tissue-level functional outcome are jointly observed.PATIENT_SCALELOCKED NO LONGITUDINAL CALIBRATION
Patient-scale calibration
Document which longitudinal and calibration evidence is missing.
No patient digital twin, clinical trajectory forecast or therapeutic recommendation is supported.Cross-scale bridge
Five candidate links; zero simulated edges.
These are falsifiable handoffs between scales. Their labels describe missing evidence, not a generated biological effect.
01LOCKED NO MATCHED DMD RESPONSE
perturbation → cell state
Candidate-conditioned molecular response in a matched DMD model with biological repeats.
02REFERENCE ONLY NOT CAUSAL
cell state → myogenic process
Perturbation-conditioned fate measured at physical timepoints.
03LOCKED NO INTERACTION TRUTH
cell state → neighboring cell state
Spatially resolved, perturbation-matched sender/receiver measurements with negative controls.
04CONTEXT ONLY DMD OUTCOME MISSING
myogenic process → tissue function and safety
Matched DMD fusion/function and toxicity outcomes linked to molecular response.
05LOCKED NO PATIENT CALIBRATION
tissue state → patient trajectory
Longitudinal patient outcome with a prespecified calibration and uncertainty contract.
Tissue admission ledger
1 ready · 3 partial · 4 open.
LOCK_UNSUPPORTED_CROSS_SCALE_INFERENCE. A cross-scale claim remains locked until its exact context, unit, geometry, perturbation, outcome, calibration and execution objects are jointly present.
- CONTEXT_IDENTITYDisease, species, tissue and cell-state identityPARTIAL
- INDEPENDENT_UNITSIndependent-unit and nested-cell structurePARTIAL
- PHYSICAL_TIMEPhysical-time reference rather than pseudotime substitutionREADY
- SPATIAL_GEOMETRYCoordinates, section/animal identity and spatial negative controlsPARTIAL
- DMD_RESPONSECandidate-conditioned DMD responseOPEN
- CROSS_CELL_OUTCOMEMatched sender/receiver and tissue outcomeOPEN
- PATIENT_CALIBRATIONLongitudinal patient calibrationOPEN
- REGISTERED_EXECUTIONRegistered multiscale task, model and receiptOPEN
Claim boundary
Zero new datasets · zero new runs · zero new scientific claims.
The Digital Tissue workspace links measured context, time and spatial references to explicit cross-scale gaps. It is a hypothesis and experiment-design layer, not a multicellular simulator, patient twin or efficacy model.
Does not imply: cell-cell simulation · perturbation-conditioned spatial prediction · tissue-level rescue · patient trajectory forecasting · clinical or therapeutic validity.