{
  "registry_schema": "nmd-vcell-multidisease-spatial-task-registry/1.0",
  "generated_at": "2026-09-09",
  "score_policy": "No cross-disease therapeutic score or pooled biological rank is permitted.",
  "disease_tasks": [
    {
      "disease": "DMD",
      "module_release": "multidisease-evidence-v0.2.0",
      "etiologic_anchor": "Dystrophin loss",
      "module_status": "CORE_MEASURED_CONTEXT_PROSPECTIVE_CANDIDATE_VALIDATION",
      "biological_axis": "dystrophin loss → injury/regeneration and locus-correction reference",
      "primary_endpoint": "molecular correction plus fusion/function in matched DMD models",
      "independent_unit": "sample or independently named DMD/isogenic model pair",
      "next_gate": "candidate-conditioned DMD perturbation outcome",
      "claim_boundary": {
        "supports": [
          "measured DMD induction and locus correction",
          "small-n patient-muscle pathway replication",
          "prospective candidate experiment design"
        ],
        "does_not_support": [
          "measured candidate-level DMD response",
          "therapeutic efficacy",
          "patient-level simulation or clinical recommendation"
        ]
      },
      "route": "/resource/disease/dmd/"
    },
    {
      "disease": "FSHD",
      "module_release": "multidisease-evidence-v0.2.0",
      "etiologic_anchor": "DUX4",
      "module_status": "MEASURED_PATIENT_STATE_AND_INDUCED_TIMING",
      "biological_axis": "DUX4 state and induced temporal injury response",
      "primary_endpoint": "DUX4-target and membrane-injury response",
      "independent_unit": "biological line/donor; cells and wells stay nested",
      "next_gate": "additional donor/line replication with prespecified injury endpoint",
      "claim_boundary": {
        "supports": [
          "DUX4-target state stratification",
          "induction kinetics",
          "stress-intervention experiment design"
        ],
        "does_not_support": [
          "patient-calibrated efficacy",
          "therapeutic ranking",
          "donor-general disease prevalence from one donor per state"
        ]
      },
      "route": "/resource/disease/fshd/"
    },
    {
      "disease": "DM1",
      "module_release": "multidisease-evidence-v0.2.0",
      "etiologic_anchor": "DMPK CTG repeat",
      "module_status": "MEASURED_PATIENT_AND_CORRECTED_ISOGENIC",
      "biological_axis": "DMPK CTG repeat, isogenic correction and splicing convergence",
      "primary_endpoint": "event-level splicing correction",
      "independent_unit": "independent biopsy for patient inference; clone for isogenic reference",
      "next_gate": "patient-level functional endpoint linked to corrected splicing",
      "claim_boundary": {
        "supports": [
          "isogenic molecular correction reference",
          "patient exon-skipping map",
          "typed functional splicing endpoints"
        ],
        "does_not_support": [
          "global expression rescue",
          "clinical prognosis",
          "clone-to-patient equivalence",
          "treatment ranking"
        ]
      },
      "route": "/resource/disease/dm1/"
    },
    {
      "disease": "SMA",
      "module_release": "multidisease-evidence-v0.2.0",
      "etiologic_anchor": "SMN1 / SMN2",
      "module_status": "MEASURED_NEURAL_RESPONSE_AND_RESIDUAL_MUSCLE",
      "biological_axis": "SMN1/SMN2 neural intervention and residual treated-muscle state",
      "primary_endpoint": "line-level neural response plus disease-specific function",
      "independent_unit": "donor-derived line or independent patient sample",
      "next_gate": "replicated functional outcome without assuming global expression reversal",
      "claim_boundary": {
        "supports": [
          "human neural disease/intervention response",
          "source-reported SMN2 splicing and functional rescue",
          "KIF5A downstream mechanism",
          "residual-muscle hypotheses"
        ],
        "does_not_support": [
          "global gene-expression reversal",
          "significant OXPHOS/denervation/fibrosis module claim in this reanalysis",
          "patient motor-outcome prediction",
          "combination-therapy ranking"
        ]
      },
      "route": "/resource/disease/sma/"
    }
  ],
  "spatial_tasks": [
    {
      "task_id": "SPATIAL-GSE297388-REPRESENTATION-STABILITY",
      "dataset": "GSE297388",
      "comparison": "two mdx strain backgrounds; not DMD versus wild type",
      "released_observations": "7,509 spots × 128 dimensions across 4 sections",
      "independent_unit": "section for resampling; animal identity must be confirmed before animal-level generalization",
      "random_feature_dropout": "10% dropout median cosine 0.9988",
      "panel_shift": "1,000-HVG panel: 554 exact-mapped, 446 zero-filled, median cosine 0.5581",
      "interpretation": "Random feature-dropout stability does not establish gene-panel transfer.",
      "required_sensitivity": [
        "section leave-one-out",
        "animal identity audit",
        "panel overlap curve",
        "composition/batch/spatial-position negative controls"
      ]
    },
    {
      "task_id": "NONSPATIAL-GSE277637-CONTEXT",
      "dataset": "GSE277637",
      "spatial_eligibility": "INELIGIBLE_NO_COORDINATES",
      "released_observations": "10,480 cells across 4 lines with one shared WT",
      "interpretation": "May inform line-aware disease context, but cannot be merged into a spatial benchmark."
    }
  ]
}