Release 2026.08DMD context observedDMD candidate-conditioned prediction not yet eligible
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Evidence freeze: 3 August 2026Resource: v1.2.0-measured-dmd-evidenceSchema: 1.1Open release status →
DMD Biological Process Map V1.1
Explore DMD as a biological system—not a list of cell cards.
An evidence-aware skeletal-muscle process graph connects myofibre injury, immune states, myogenic transitions, FAP/ECM remodeling, vascular context and function. Every node and edge declares question identity plus evidence metadata: origin, context match, unit structure, lifecycle and outcome fields.
GSE288958Human DMD/BMD/control muscle snRNA-seq and spatial contextgse288958_sample_aware_module_context_v01
CONTEXT_READY
9 nodes · 4 edges
context ready
Use the read-only sample-aware reference with Normal_2, Scrublet and annotation-disagreement sensitivities. Unfiltered droplets or author contamination estimates are needed only to close ambient RNA; exact author artifacts are needed only for an author-exact reprocessing claim.
GSE293514Human myoblast fusion CRISPR screen and CROP-seq context
IDENTITY_BLOCKED
2 nodes · 2 edges
intake gate
Recover author-ordered feature table, guide reference, exact cell metadata and processing contract; checksum every returned file before any expression transfer.
Current actionable gap: GSE277637 maps to four target-context process nodes. GSE288958 is now CONTEXT_READY with a sample-aware context object, read-only QC, donor-wise Scrublet and independent annotation-disagreement audits; its 1,967-cell raw-to-object gap, ambient-RNA boundary and author-exact reprocessing gap remain visible. Neither source establishes a cell-state transition, macrophage/FAP communication, candidate perturbation response or function.
Evidence Inspector
Click a node or edge to inspect its claim ceiling.
Spatial co-localization, ligand–receptor inference and trajectory references retain explicit evidence metadata. They never silently become causal edges.
State transition contract
The first computable transition layer is myogenic; DMD-conditioned transitions remain NOT ESTIMABLE.
GSE52529 and GSE293514 provide unperturbed time and healthy-myoblast context.
Missing DMD outcomeDMD myogenic perturbation → regenerated fibre → function
Candidate-level DMD outcomes have not yet been measured; missing is not negative.
Future outputP(state A → B) + uncertainty + abstention
Only after donor, time, perturbation and functional outcomes are frozen and measured.
Claim boundary
Mechanism → experiment → outcome → claim update
DMD Biological Process Map V1.0 is an evidence-aware mechanistic map. It is not a causal network, perturbation-conditioned virtual-cell prediction, patient simulation, treatment ranking or clinical decision system. Missing is not negative, and layout is not biology.