NMD-VCell Research Workbench Module: Validate / registry · evidence-to-experiment workflow NMD = neuromuscular disorders
v1.0 candidate Frozen 25 Jul 2026 DOI pending
v1.0.0-database-resource Schema 1.1 Model ridge-safe-v2.3 Benchmark repeated-fold-v2.2 Build EA-20260729-15 v1.0 is a database and evidence-governance release; it is not a validated disease-prediction or clinical decision-support release.
Current evidence ceiling L2 observed HepG2 limited L3a context No independent DMD perturbation validation Open boundary

Reviewer guided tour

Review the Workbench in one bounded path.

This page gives reviewers a short route through the productized surfaces added around the frozen database resource: gene profile, comparison dashboard, Planner builder, visual Study Card and validation/registry gates.

Release ceilingv1.0 is a database and evidence-governance release; it is not a validated disease-prediction or clinical decision-support release. Formal v1.0 remains externally gated by DOI, licence and maintainer/contact metadata.

Reviewer guided tour

Search gene → Compare candidates → Build Study Card → Inspect visual card → Validate/register

This pipeline-style tour tells a first-time reviewer what to open, what visual result to expect and which boundary must remain intact.

Do not overclaimNo ranking, no therapeutic efficacy, no clinical decision support and no P1/P2 disease-prediction unlock.

Three example entrypoints

A reviewer can inspect three different branches immediately

Muscle-context assay

ZNF133

Use this first to see the full evidence-to-experiment route for a muscle-assay draft.

Verify expression

CPEB1

Use this to inspect the expression-feasibility branch before perturbation escalation.

External evidence audit / hold

GFOD2

Use this to confirm that provisional external evidence is not silently promoted without provenance.

What this tour demonstrates

A governed evidence-to-experiment product path

The tour links existing visual surfaces: gene profile, comparison dashboard, Planner builder, Study Card visual summary and registry/validation gates.

What it does not demonstrate

No disease-prediction or therapeutic claim

The guided tour is a reading path through frozen objects. It does not change evidence levels, infer missing approvals, mint a DOI or authorize formal v1.0.

What visual result should I see?

Each stop has one primary visual check

StopExpected visual resultBoundary check
1 · Search gene Start with one typed gene recordGene visual profileA single gene view reorganizes frozen fields only; it does not create a new rank.
2 · Compare candidates Contrast a small candidate setComparison visual dashboardInput order is preserved; no winner, score, cluster or therapeutic priority is computed.
3 · Build Study Card Generate the next-experiment routePlanner visual builderThe Planner is a pipeline-style route, not an intervention recommender.
4 · Inspect visual card Read the stable Study Card objectStudy Card visual summaryCards remain DRAFT until required fields are registered and checksummed.
5 · Validate/register Confirm gates before any claim expansionValidation and registry gatesP1/P2 prediction claims remain locked; formal v1.0 still requires external gates.

Identity and citation anchors

Files a reviewer should cite or checksum

ObjectPathPurpose
Release manifestapi/v1.1/release_manifest.jsonCurrent database-resource identity and archive pointers.
Overlay identityapi/v1.1/overlay_archive_identity.jsonCurrent Workbench overlay filename, size and SHA-256.
Reviewer entrypointsapi/v1.1/reviewer_entrypoints.jsonMachine-readable guided-tour path used by this page.
Deposit manifestdownloads/v1_deposit_manifest.jsonCurrent DOI deposit candidate file set and supporting objects.
QA statusapi/v1.1/site_quality_status.jsonMachine-readable website quality and lock status.
External gate handoffdownloads/V1_EXTERNAL_GATE_HANDOFF.mdHuman/institution inputs required before formal v1.0.

External gate reminder

Formal v1.0 remains locked until DOI, institution-approved data licence, institution-approved code licence, and author/institution-approved maintainer/contact metadata are supplied and validated through the strict external gate validator.

Open external authorization dossier · Download external gate handoff