ZNF133
Use this first to see the full evidence-to-experiment route for a muscle-assay draft.
Reviewer guided tour
Review the Workbench in one bounded path.
This page gives reviewers a short route through the productized surfaces added around the frozen database resource: gene profile, comparison dashboard, Planner builder, visual Study Card and validation/registry gates.
Science Advances v09.80 manuscript/figure packet is local source staging only; not a production deployment or final submission freeze.
NAR v08.7 design-sensitivity route
Audit the pilot interpretation from result to source table.
This additive review layer is separate from the Science Advances v09.80 packet and leaves the v1.2 scientific resource release unchanged.
01 · InterpretationRead addendum manifestTwo independent pairs remain a bounded pilot.02 · FigureInspect Figure S32 manifestFour panels, vector PDF and source data.03 · Full gridAudit all 480 scenarios via manifestTable_S65_full_grid_v087.tsv · 20,000 replicates per scenario.04 · Machine recordVerify values and claim boundaryFormal unlocks remain empty.
Science Advances review route
Verify manuscript claims in a fixed order before judging model scope.
Use these five objects as the reviewer path for the v09.80 manuscript/figure packet. Each step points to a checksummed source object and preserves the local-staging boundary.
01 · Manuscript packetVerify the staged v09.80 packet manifestManuscript, all six main figures, caption book, LaTeX include and audit report. Verify ZIP SHA a840f05b… before reuse.
02 · Figure/Table TraceCheck every figure has source-data provenanceARS trace entries = 6. Missing figure_table_trace is a blocking integrity failure, not a cosmetic issue.
03 · Figure 3 audit matrixInspect the candidate-assignment evidence mapFigure 3 is the source-bound audit matrix, not an independent validation claim or candidate rank.
04 · Downloads manifestConfirm public file registry and staged pathsThe manifest shows the served packet objects and their local site-source staging status.
05 · Claim boundaryStop at the declared claim ceilingNo P1/P2 disease prediction, therapeutic efficacy, clinical decision support or formal submission freeze is unlocked here.
Boundary: Local staging only; not a production deployment or final submission freeze.
Choose the object under review
The DMD workbench and the four-disease atlas are related, but not interchangeable.
DMD workbench pathGene → comparison → Study Card → registryUse this path to audit the 21 governed DMD candidates and prospective validation lifecycle.
Four-disease atlas pathDisease → evidence axes → candidate roles → next experimentUse this path to audit DMD, FSHD, DM1 and SMA without assuming a shared predictor or pooled score.
Reviewer guided tour
Search gene → Compare candidates → Build Study Card → Inspect visual card → Validate/register
This pipeline-style tour tells a first-time reviewer what to open, what visual result to expect and which boundary must remain intact.
Do not overclaimNo ranking, no therapeutic efficacy, no clinical decision support and no P1/P2 disease-prediction unlock.
1 · Search gene
Start with one typed gene record
Gene visual profile
A single gene view reorganizes frozen fields only; it does not create a new rank.
2 · Compare candidates
Contrast a small candidate set
Comparison visual dashboard
Input order is preserved; no winner, score, cluster or therapeutic priority is computed.
3 · Build Study Card
Generate the next-experiment route
Planner visual builder
The Planner is a pipeline-style route, not an intervention recommender.
4 · Inspect visual card
Read the stable Study Card object
Study Card visual summary
Cards remain DRAFT until required fields are registered and checksummed.
5 · Validate/register
Confirm gates before any claim expansion
Validation and registry gates
P1/P2 prediction claims remain locked; formal v1.0 still requires external gates.
Three example entrypoints
A reviewer can inspect three different branches immediately
CPEB1
Use this to inspect the expression-feasibility branch before perturbation escalation.
GFOD2
Use this to confirm that provisional external evidence is not silently promoted without provenance.
What this tour demonstrates
A governed evidence-to-experiment product path
The tour links existing visual surfaces: gene profile, comparison dashboard, Planner builder, Study Card visual summary and registry/validation gates.
What it does not demonstrate
No disease-prediction or therapeutic claim
The guided tour is a reading path through frozen objects. It does not change evidence levels, infer missing approvals, mint a DOI or authorize formal v1.0.
What visual result should I see?
Each stop has one primary visual check
| Stop | Expected visual result | Boundary check |
|---|---|---|
| 1 · Search gene Start with one typed gene record | Gene visual profile | A single gene view reorganizes frozen fields only; it does not create a new rank. |
| 2 · Compare candidates Contrast a small candidate set | Comparison visual dashboard | Input order is preserved; no winner, score, cluster or therapeutic priority is computed. |
| 3 · Build Study Card Generate the next-experiment route | Planner visual builder | The Planner is a pipeline-style route, not an intervention recommender. |
| 4 · Inspect visual card Read the stable Study Card object | Study Card visual summary | Cards remain DRAFT until required fields are registered and checksummed. |
| 5 · Validate/register Confirm gates before any claim expansion | Validation and registry gates | P1/P2 prediction claims remain locked; formal v1.0 still requires external gates. |
Identity and citation anchors
Files a reviewer should cite or checksum
| Object | Path | Purpose |
|---|---|---|
| Current platform manifest | api/current/release_manifest.json | Current release, overlay, disease modules and locked prediction boundary. |
| Base publication snapshot manifest | api/releases/v1.0.0-database-resource/release_manifest.json | Frozen database-paper identity retained separately from the live platform. |
| Overlay identity | api/v1.1/overlay_archive_identity.json | Current Workbench overlay filename, size and SHA-256. |
| Reviewer entrypoints | api/v1.1/reviewer_entrypoints.json | Machine-readable guided-tour path used by this page. |
| Deposit manifest | downloads/v1_deposit_manifest.json | Current DOI deposit candidate file set and supporting objects. |
| QA status | api/v1.1/site_quality_status.json | Machine-readable website quality and lock status. |
| External gate handoff | downloads/V1_EXTERNAL_GATE_HANDOFF.md | Human/institution inputs required before formal v1.0. |
External gate reminder
Formal v1.0 remains locked until DOI, institution-approved data licence, institution-approved code licence, and author/institution-approved maintainer/contact metadata are supplied and validated through the strict external gate validator.
Open external authorization dossier · Download external gate handoff