{
  "schema": "nmd-vcell-claim-registry/1.0",
  "updated": "2026-09-15",
  "authority_rule": "Claim objects encode already-supported statements, engineering states, publication states or explicit evidence boundaries. Registering a claim object does not create a new scientific result.",
  "claim_object_schema": "/resource/api/v2/claim.schema.json",
  "record_count": 6,
  "new_scientific_claim_count": 0,
  "records": [
    {
      "claim_id": "CLAIM:DMD:CANDIDATE_OUTCOME_BOUNDARY:V1",
      "version": "1.0.0",
      "title": "DMD candidate outcome boundary",
      "claim_class": "scientific_boundary",
      "claim_scope": "EVIDENCE_BOUNDARY",
      "statement": "The 21 governed DMD candidates have 0 directly measured disease-matched perturbation outcomes.",
      "evidence_state": "MISSING",
      "lifecycle_state": "ACTIVE",
      "subject_ids": [
        "DISEASE:DMD",
        "CANDIDATE_SET:DMD:21"
      ],
      "quantitative_state": {
        "governed_candidates": 21,
        "directly_measured_disease_matched_outcomes": 0
      },
      "evidence_objects": [
        {
          "object_id": "REGISTRY:CANDIDATE_DECISIONS:CURRENT",
          "role": "RECORDS_ABSENCE",
          "public_path": "/resource/api/v1.1/candidate_decision_registry.json"
        },
        {
          "object_id": "REGISTRY:REGISTERED_STUDIES:CURRENT",
          "role": "RECORDS_ABSENCE",
          "public_path": "/resource/api/v1.1/registered_studies.json"
        },
        {
          "object_id": "REGISTRY:EXPERIMENTAL_OUTCOMES:CURRENT",
          "role": "RECORDS_ABSENCE",
          "public_path": "/resource/api/v1.1/experimental_outcomes.json"
        }
      ],
      "claim_ceiling": "This is an evidence-availability statement. It supports abstention and next-experiment planning, not efficacy or inefficacy.",
      "does_not_imply": [
        "candidate efficacy",
        "candidate inefficacy",
        "therapeutic ranking",
        "clinical recommendation"
      ],
      "next_evidence": "A preregistered disease-matched perturbation study with independent biological units, matched controls, target engagement and a functional outcome.",
      "generated_by": [
        "PROCESS:CLAIM_REGISTRY_BUILD:V196"
      ],
      "used_by": [
        {
          "object_id": "SURFACE:DMD_WORKSPACE",
          "public_path": "/resource/disease/dmd/"
        },
        {
          "object_id": "SURFACE:EVIDENCE_STATUS",
          "public_path": "/resource/evidence-status/"
        }
      ],
      "claim_dependencies": [],
      "supersedes": [],
      "is_new_scientific_claim": false,
      "claim_object_sha256": "a816e2ade8cb114335716cddc27900cbb36ca9f2e113b022938ffbd08533b3a8"
    },
    {
      "claim_id": "CLAIM:P59:TRANSPORT_AND_PLATES_COMPLETE:V1",
      "version": "1.0.0",
      "title": "P59 transport and plate-statistics completion",
      "claim_class": "engineering_status",
      "claim_scope": "ENGINEERING_STATUS",
      "statement": "GSE306429 completed transport for 52/52 authorized archives and fixed plate sufficient-statistics for 44/44 primary archives.",
      "evidence_state": "OBSERVED_ENGINEERING",
      "lifecycle_state": "ACTIVE",
      "subject_ids": [
        "DATASET:GSE306429",
        "PUBLICATION_PACKAGE:PUB:SCIENCE_ADVANCES:P59:20260911"
      ],
      "quantitative_state": {
        "authorized_archives": 52,
        "transported_archives": 52,
        "primary_archives": 44,
        "completed_primary_plate_statistics": 44
      },
      "evidence_objects": [
        {
          "object_id": "STATUS:SUPPORT_AWARE:CURRENT",
          "role": "SUPPORTS",
          "public_path": "/resource/api/v1.1/support_aware_status.json"
        },
        {
          "object_id": "REGISTRY:PUBLICATION_PACKAGES:V2",
          "role": "LIMITS",
          "public_path": "/resource/api/v2/publication_packages.json"
        }
      ],
      "claim_ceiling": "Transport and plate-statistics completion are engineering observations; they do not establish successful target scoring or perturbation-transfer performance.",
      "does_not_imply": [
        "successful target scoring",
        "model performance",
        "DMD efficacy"
      ],
      "next_evidence": "A governed scorer execution that either produces a valid target-score object or retains a new failure receipt.",
      "generated_by": [
        "PROCESS:CLAIM_REGISTRY_BUILD:V196"
      ],
      "used_by": [
        {
          "object_id": "SURFACE:SUPPORT_AWARE",
          "public_path": "/resource/support-aware"
        },
        {
          "object_id": "SURFACE:EVIDENCE_STATUS",
          "public_path": "/resource/evidence-status/"
        }
      ],
      "claim_dependencies": [],
      "supersedes": [],
      "is_new_scientific_claim": false,
      "claim_object_sha256": "eafdc0ae720a1f01129dd13bb4bbbb0fa800e354b023c5d3c195ee051cd2f4a6"
    },
    {
      "claim_id": "CLAIM:P59:PRIMARY_SCORER_FAILURE:V1",
      "version": "1.0.0",
      "title": "P59 primary scorer failure",
      "claim_class": "failure_record",
      "claim_scope": "ENGINEERING_STATUS",
      "statement": "The GSE306429 primary scorer failed before target effects or target scores were created because object arrays could not be loaded with allow_pickle=False.",
      "evidence_state": "FAILURE_RETAINED",
      "lifecycle_state": "ACTIVE",
      "subject_ids": [
        "DATASET:GSE306429",
        "PROCESS:P59:PRIMARY_SCORER"
      ],
      "quantitative_state": {
        "target_effects_created": false,
        "target_scores_created": false,
        "error_type": "ValueError",
        "error": "Object arrays cannot be loaded when allow_pickle=False"
      },
      "evidence_objects": [
        {
          "object_id": "STATUS:SUPPORT_AWARE:CURRENT",
          "role": "RECORDS_FAILURE",
          "public_path": "/resource/api/v1.1/support_aware_status.json"
        },
        {
          "object_id": "PACKAGE:SCIENCE_ADVANCES:P59",
          "role": "LIMITS",
          "public_path": "/resource/api/v2/publication_packages.json"
        }
      ],
      "claim_ceiling": "A retained engineering failure is evidence about execution state, not evidence for or against biological transfer performance.",
      "does_not_imply": [
        "poor model performance",
        "successful model performance",
        "candidate efficacy",
        "candidate inefficacy"
      ],
      "next_evidence": "Execute the predeclared metadata-only repair under a superseding receipt while preserving numeric arrays, axes, genes, routes, items and thresholds.",
      "generated_by": [
        "PROCESS:CLAIM_REGISTRY_BUILD:V196"
      ],
      "used_by": [
        {
          "object_id": "SURFACE:SUPPORT_AWARE",
          "public_path": "/resource/support-aware"
        },
        {
          "object_id": "SURFACE:PUBLICATIONS",
          "public_path": "/resource/publications/"
        }
      ],
      "claim_dependencies": [],
      "supersedes": [],
      "is_new_scientific_claim": false,
      "claim_object_sha256": "7df49d332079288546b0b346f159b0c2f91d100c75c61544842d7404fd835493"
    },
    {
      "claim_id": "CLAIM:P59:NO_TARGET_SCORE:V1",
      "version": "1.0.0",
      "title": "P59 target result remains absent",
      "claim_class": "missing_result",
      "claim_scope": "MISSING_RESULT",
      "statement": "No GSE306429 target-effect table, target-score object or target-result Figure S3 exists in the P59 state.",
      "evidence_state": "MISSING",
      "lifecycle_state": "BLOCKED",
      "subject_ids": [
        "DATASET:GSE306429",
        "RESULT:P59:TARGET_SCORE",
        "FIGURE:P59:S3"
      ],
      "quantitative_state": {
        "target_effects_created": false,
        "target_scores_created": false,
        "target_result_figure": "ABSENT_NO_TARGET_SCORE"
      },
      "evidence_objects": [
        {
          "object_id": "STATUS:SUPPORT_AWARE:CURRENT",
          "role": "RECORDS_ABSENCE",
          "public_path": "/resource/api/v1.1/support_aware_status.json"
        }
      ],
      "claim_ceiling": "Absence of the target result requires abstention. It is neither a null result nor a negative performance finding.",
      "does_not_imply": [
        "null biological effect",
        "negative transfer performance",
        "positive transfer performance",
        "completed Figure S3"
      ],
      "next_evidence": "A successful governed primary-scorer output with checksummed target effects, scores and a separately generated figure.",
      "generated_by": [
        "PROCESS:CLAIM_REGISTRY_BUILD:V196"
      ],
      "used_by": [
        {
          "object_id": "SURFACE:SUPPORT_AWARE",
          "public_path": "/resource/support-aware"
        },
        {
          "object_id": "SURFACE:EVIDENCE_STATUS",
          "public_path": "/resource/evidence-status/"
        }
      ],
      "claim_dependencies": [
        {
          "claim_id": "CLAIM:P59:PRIMARY_SCORER_FAILURE:V1",
          "relation": "MISSING_BECAUSE"
        }
      ],
      "supersedes": [],
      "is_new_scientific_claim": false,
      "claim_object_sha256": "a43a6680c4490ec6daedc4a2662f93f806d3e9de55f4df672fc5aa23cdf76681"
    },
    {
      "claim_id": "CLAIM:SUPPORT_AWARE:RANKING_UTILITY_SEPARATION:V1",
      "version": "1.0.0",
      "title": "Failure ranking and utility remain distinct",
      "claim_class": "scientific_interpretation",
      "claim_scope": "BOUNDED_SCIENTIFIC_INTERPRETATION",
      "statement": "Within the fixed historical evidence base, failure ranking and utility are treated as distinct endpoints; the strict evidence base remains three study-level groups and P59 adds zero independent groups.",
      "evidence_state": "BOUNDED_INTERPRETATION",
      "lifecycle_state": "ACTIVE",
      "subject_ids": [
        "RESEARCH_PROGRAM:SUPPORT_AWARE_TRANSFER",
        "PUBLICATION_PACKAGE:PUB:SCIENCE_ADVANCES:P59:20260911"
      ],
      "quantitative_state": {
        "strict_independent_groups": 3,
        "p59_independent_group_increment": 0
      },
      "evidence_objects": [
        {
          "object_id": "STATUS:SUPPORT_AWARE:CURRENT",
          "role": "SUPPORTS",
          "public_path": "/resource/api/v1.1/support_aware_status.json"
        },
        {
          "object_id": "PACKAGE:SCIENCE_ADVANCES:P59",
          "role": "LIMITS",
          "public_path": "/resource/api/v2/publication_packages.json"
        }
      ],
      "claim_ceiling": "This is a bounded interpretation of fixed historical replays. P59 does not add a target score, an independent study group or DMD functional evidence.",
      "does_not_imply": [
        "generalized perturbation-transfer performance",
        "prospective validation",
        "DMD efficacy"
      ],
      "next_evidence": "Independent predeclared replication with separated custody and a successfully scored target outcome.",
      "generated_by": [
        "PROCESS:CLAIM_REGISTRY_BUILD:V196"
      ],
      "used_by": [
        {
          "object_id": "SURFACE:SUPPORT_AWARE",
          "public_path": "/resource/support-aware"
        },
        {
          "object_id": "PACKAGE:SCIENCE_ADVANCES:P59",
          "public_path": "/resource/api/v2/publication_packages.json"
        }
      ],
      "claim_dependencies": [
        {
          "claim_id": "CLAIM:P59:NO_TARGET_SCORE:V1",
          "relation": "LIMITED_BY"
        }
      ],
      "supersedes": [],
      "is_new_scientific_claim": false,
      "claim_object_sha256": "7ef971a82328f120bd754744c9059c90845679fefa7ab097b51564f4975616b0"
    },
    {
      "claim_id": "CLAIM:NAR:CURATED_V08_WORKING_STATE:V1",
      "version": "1.0.0",
      "title": "NAR curated v08 working-package state",
      "claim_class": "publication_status",
      "claim_scope": "PUBLICATION_STATUS",
      "statement": "The current NAR curated v08 working package has 6 main figures, 31 supplementary figures, 47 governed members and 15/15 technical checks passed, but it is not submission-ready.",
      "evidence_state": "WORKING",
      "lifecycle_state": "ACTIVE",
      "subject_ids": [
        "PUBLICATION_PACKAGE:PUB:NAR:CURATED_V08_STORY:20260818"
      ],
      "quantitative_state": {
        "main_figure_count": 6,
        "supplementary_figure_count": 31,
        "package_file_count": 47,
        "technical_validation_checks_passed": 15,
        "technical_validation_checks_total": 15,
        "formal_submission_ready": false
      },
      "evidence_objects": [
        {
          "object_id": "REGISTRY:NAR:PUBLICATION_PACKAGE:V1",
          "role": "DEFINES_MEMBERSHIP",
          "public_path": "/resource/api/v1.1/publication_package_registry.json"
        },
        {
          "object_id": "REGISTRY:PUBLICATION_PACKAGES:V2",
          "role": "LIMITS",
          "public_path": "/resource/api/v2/publication_packages.json"
        }
      ],
      "claim_ceiling": "Technical completeness and package membership do not confer author approval, DOI deposit or formal submission readiness.",
      "does_not_imply": [
        "author approval",
        "formal submission readiness",
        "DOI deposit",
        "new scientific evidence"
      ],
      "next_evidence": "Author review, final scientific approval and external submission/deposit receipts.",
      "generated_by": [
        "PROCESS:CLAIM_REGISTRY_BUILD:V196"
      ],
      "used_by": [
        {
          "object_id": "SURFACE:PUBLICATIONS",
          "public_path": "/resource/publications/"
        },
        {
          "object_id": "SURFACE:EVIDENCE_STATUS",
          "public_path": "/resource/evidence-status/"
        }
      ],
      "claim_dependencies": [],
      "supersedes": [],
      "is_new_scientific_claim": false,
      "claim_object_sha256": "e66bc7f61039e08ab1c3766de243fcbc42fba99bc74a1afc3492a95ca4b0a0db"
    }
  ],
  "claim_set_sha256": "970a1f12ff43e8c39449d21cb4ac07b31ecb80d93d5889c828a269df54337e3b"
}