{
  "schema": "nmd-vcell-measured-dmd-evidence-release-manifest/1.0",
  "object_id": "MDEMANIFEST:v1.2.0-measured-dmd-evidence:EA-20260804-49",
  "resource_release": "v1.2.0-measured-dmd-evidence",
  "interface_build": "EA-20260804-49",
  "evidence_freeze": "2026-08-03",
  "object_count": 33,
  "objects": [
    {
      "role": "replicate_aware_camera_tests",
      "path": "downloads/gse272233_camera_reactome_tests_v1.tsv.gz",
      "href": "/resource/downloads/gse272233_camera_reactome_tests_v1.tsv.gz",
      "size_bytes": 360599,
      "sha256": "3c7091f678de33b33cc53e2ac5e5fc29c148987e2252ed8124638f88b634ab89"
    },
    {
      "role": "background_pathway_reversal",
      "path": "downloads/gse272233_background_pathway_reversal_v1.tsv.gz",
      "href": "/resource/downloads/gse272233_background_pathway_reversal_v1.tsv.gz",
      "size_bytes": 665594,
      "sha256": "bf0718e0f67b136c863012e886bb3ddeb986aa59eb79bf2e757833b40fabdce0"
    },
    {
      "role": "cross_background_consensus_and_heterogeneity",
      "path": "downloads/gse272233_cross_background_reversal_consensus_v1.tsv",
      "href": "/resource/downloads/gse272233_cross_background_reversal_consensus_v1.tsv",
      "size_bytes": 1387093,
      "sha256": "15cadd2cfc6250fd8059f1a1177fa70e1c05e082d325b2decece37f15b7c8276"
    },
    {
      "role": "gse272233_sample_qc",
      "path": "downloads/gse272233_sample_qc_v1.tsv",
      "href": "/resource/downloads/gse272233_sample_qc_v1.tsv",
      "size_bytes": 2801,
      "sha256": "15e0fcdcd5da33bf3a66bfa4dd1c35154d1d2af5740c1971e0c46ca8eb7c164b"
    },
    {
      "role": "gse272233_analysis_report",
      "path": "downloads/GSE272233_REPLICATE_AWARE_REACTOME_REPORT_v1.md",
      "href": "/resource/downloads/GSE272233_REPLICATE_AWARE_REACTOME_REPORT_v1.md",
      "size_bytes": 1785,
      "sha256": "ba1a819bb5998510957078e035d4561a3dbf1aee2e990e3ceb0082bd06188ce2"
    },
    {
      "role": "external_pathway_effects",
      "path": "downloads/external_dmd_pathway_effects_v1.tsv.gz",
      "href": "/resource/downloads/external_dmd_pathway_effects_v1.tsv.gz",
      "size_bytes": 213708,
      "sha256": "ac4be8ee984e4304a7e0c331e87df727bcbce85ae0f3e14999914e692bb8f2e6"
    },
    {
      "role": "cross_dataset_direction_consensus",
      "path": "downloads/external_dmd_cross_dataset_pathway_consensus_v1.tsv",
      "href": "/resource/downloads/external_dmd_cross_dataset_pathway_consensus_v1.tsv",
      "size_bytes": 298089,
      "sha256": "d077609c3f8ac10f8fae85aa1039e132efb8e20aed658c62a7b523a25a4feb85"
    },
    {
      "role": "external_disease_to_correction_reversal",
      "path": "downloads/external_disease_to_gse272233_correction_reversal_v1.tsv.gz",
      "href": "/resource/downloads/external_disease_to_gse272233_correction_reversal_v1.tsv.gz",
      "size_bytes": 1367774,
      "sha256": "a3c2eb588d6d8cde2bb7a3f7732def926fba2b8ce33b948e5974742d005bf42f"
    },
    {
      "role": "independent_patient_camera_tests",
      "path": "downloads/prjna772047_camera_reactome_tests_v1.tsv",
      "href": "/resource/downloads/prjna772047_camera_reactome_tests_v1.tsv",
      "size_bytes": 147020,
      "sha256": "3897e50f649ab559983c2c2c57370257e9631d7f535f19cc84fb6eda6ceeb367"
    },
    {
      "role": "external_sample_qc",
      "path": "downloads/external_dmd_sample_qc_v1.tsv",
      "href": "/resource/downloads/external_dmd_sample_qc_v1.tsv",
      "size_bytes": 1265,
      "sha256": "9c660a4e0987d6905405f979793a1aee2e81690518cc4956289c75cd36524922"
    },
    {
      "role": "external_validation_report",
      "path": "downloads/EXTERNAL_DMD_PATHWAY_REVERSAL_REPORT_v1.md",
      "href": "/resource/downloads/EXTERNAL_DMD_PATHWAY_REVERSAL_REPORT_v1.md",
      "size_bytes": 1095,
      "sha256": "c06cb2e1a6428eff017d8289bb7d51b532abd30603b2bb3ee2ce94549cb59dda"
    },
    {
      "role": "nar_main_figure_pdf",
      "path": "downloads/figure8_measured_dmd_evidence_v1.pdf",
      "href": "/resource/downloads/figure8_measured_dmd_evidence_v1.pdf",
      "size_bytes": 51648,
      "sha256": "78899290c1e66dd3f96727db68449b3a4c8966e5dcaf8fa4f51859e56bd3924d"
    },
    {
      "role": "nar_main_figure_png",
      "path": "downloads/figure8_measured_dmd_evidence_v1.png",
      "href": "/resource/downloads/figure8_measured_dmd_evidence_v1.png",
      "size_bytes": 1428055,
      "sha256": "b1d04dac970a23b113ace9ddde5d76ce24267a012066619193b39609cc2742ea"
    },
    {
      "role": "nar_main_figure_source_data",
      "path": "downloads/figure8_measured_dmd_evidence_source_data_v1.tsv",
      "href": "/resource/downloads/figure8_measured_dmd_evidence_source_data_v1.tsv",
      "size_bytes": 2034,
      "sha256": "1084f3df4e92e1972e4cdda43830aa3d78d6e3d5310e47caa3b62fe683ccd876"
    },
    {
      "role": "dataset_statistical_units",
      "path": "downloads/table5_dmd_dataset_statistical_units_v1.tsv",
      "href": "/resource/downloads/table5_dmd_dataset_statistical_units_v1.tsv",
      "size_bytes": 1376,
      "sha256": "f84ccf8da1a39450dc96200909dd00543efe4d197aa0b11343d4a3685ccad72a"
    },
    {
      "role": "candidate_truth_boundary",
      "path": "downloads/supplementary_table_candidate_dmd_truth_boundary_v1.tsv",
      "href": "/resource/downloads/supplementary_table_candidate_dmd_truth_boundary_v1.tsv",
      "size_bytes": 3998,
      "sha256": "67cb9a1c84e4ccd57a6f449a288e140df4475f6448681e4a94f3eef63cac3ee1"
    },
    {
      "role": "reproduction_code",
      "path": "downloads/build_gse272233_replicate_aware_reactome_v01.R",
      "href": "/resource/downloads/build_gse272233_replicate_aware_reactome_v01.R",
      "size_bytes": 22472,
      "sha256": "c8db655baf721f607aad0faabcdc7c6849713a74d1d67a78341964487214494d"
    },
    {
      "role": "reproduction_code",
      "path": "downloads/build_external_dmd_pathway_reversal_v01.R",
      "href": "/resource/downloads/build_external_dmd_pathway_reversal_v01.R",
      "size_bytes": 19904,
      "sha256": "e99b64f3e4066a1ef763b59f4a84f7b10bb5fc157b18b71eac4ee99b0ca4b631"
    },
    {
      "role": "reproduction_code",
      "path": "downloads/extract_remote_dmd_donor_pseudobulk_v01.py",
      "href": "/resource/downloads/extract_remote_dmd_donor_pseudobulk_v01.py",
      "size_bytes": 9543,
      "sha256": "4383a727d237c1bd449fa7a458da2f7b37db0ec631f4287f8810e0ed5fe5b33a"
    },
    {
      "role": "reproduction_code",
      "path": "downloads/build_nar_measured_dmd_figure_v01.py",
      "href": "/resource/downloads/build_nar_measured_dmd_figure_v01.py",
      "size_bytes": 21836,
      "sha256": "9979c6a599e26fbe6d8735cf81a065d8b0e75a364d67b1733607a23e4692de1a"
    },
    {
      "role": "cleanroom_reproducibility_report",
      "path": "downloads/CLEANROOM_MEASURED_DMD_REPRODUCIBILITY_REPORT_v1.md",
      "href": "/resource/downloads/CLEANROOM_MEASURED_DMD_REPRODUCIBILITY_REPORT_v1.md",
      "size_bytes": 2468,
      "sha256": "ee8d2804f67c6e0ffb312a9dfe4dd1149af2e8d6243bd1bba4cb287f8d26c68c"
    },
    {
      "role": "cleanroom_reproducibility_json",
      "path": "downloads/cleanroom_measured_dmd_reproducibility_report_v1.json",
      "href": "/resource/downloads/cleanroom_measured_dmd_reproducibility_report_v1.json",
      "size_bytes": 10498,
      "sha256": "b7951e7c70ffd04ab9d53214f2486ade6b6233ba80c32d66f3d2b2b596174b26"
    },
    {
      "role": "cleanroom_output_audit",
      "path": "downloads/cleanroom_measured_dmd_output_audit_v1.tsv",
      "href": "/resource/downloads/cleanroom_measured_dmd_output_audit_v1.tsv",
      "size_bytes": 2858,
      "sha256": "f4ea650b42ab39c4a058648b4d3b53f144f32dc3479158f1c79d6a87a78a61a3"
    },
    {
      "role": "cleanroom_input_manifest",
      "path": "downloads/cleanroom_measured_dmd_input_manifest_v1.tsv",
      "href": "/resource/downloads/cleanroom_measured_dmd_input_manifest_v1.tsv",
      "size_bytes": 931,
      "sha256": "61b0ca5d026442454555c5feb19f60c865ffe70fd2f0045a2f52fe512f9931a8"
    },
    {
      "role": "cleanroom_command_log",
      "path": "downloads/cleanroom_measured_dmd_commands_v1.log",
      "href": "/resource/downloads/cleanroom_measured_dmd_commands_v1.log",
      "size_bytes": 2661,
      "sha256": "f6d02b1b514152515530688af11d84c93be47b5afb6bf1b7ae3463dfdf1c6ff9"
    },
    {
      "role": "cleanroom_reproduction_code",
      "path": "downloads/run_cleanroom_measured_dmd_release_v01.py",
      "href": "/resource/downloads/run_cleanroom_measured_dmd_release_v01.py",
      "size_bytes": 21087,
      "sha256": "e875276c71f5041f4cea8e13b3ccd4b22e270474e09011af6f354aa21aa6b6be"
    },
    {
      "role": "api_object",
      "path": "api/v1.6/measured-dmd-evidence/gse272233-reactome.json",
      "href": "/resource/api/v1.6/measured-dmd-evidence/gse272233-reactome.json",
      "size_bytes": 2085,
      "sha256": "3db937933c38f91942a2c7c101b3b274fbf8e93a91776fefa835a866851f8239"
    },
    {
      "role": "api_object",
      "path": "api/v1.6/measured-dmd-evidence/external-validation.json",
      "href": "/resource/api/v1.6/measured-dmd-evidence/external-validation.json",
      "size_bytes": 2280,
      "sha256": "b9105370a6f447b87c3415b21e755bf20ba47cbd3ab3dc1dad5637795e846242"
    },
    {
      "role": "api_object",
      "path": "api/v1.6/measured-dmd-evidence/sample-qc.json",
      "href": "/resource/api/v1.6/measured-dmd-evidence/sample-qc.json",
      "size_bytes": 12568,
      "sha256": "1e4bb5ea433d2252708b5c044537852963fc6faa29b44fcc4e44452ae30ffdee"
    },
    {
      "role": "api_object",
      "path": "api/v1.6/measured-dmd-evidence/statistical-units.json",
      "href": "/resource/api/v1.6/measured-dmd-evidence/statistical-units.json",
      "size_bytes": 2778,
      "sha256": "443d9c05adcf48be2477445a2d465a428884f5b35e545163a6c75dd393dbcc22"
    },
    {
      "role": "api_object",
      "path": "api/v1.6/measured-dmd-evidence/candidate-truth-boundary.json",
      "href": "/resource/api/v1.6/measured-dmd-evidence/candidate-truth-boundary.json",
      "size_bytes": 9776,
      "sha256": "e62106e68d8e0f68da2bee9d581e4091aa0f10ecc59deba61adf1028bce553d6"
    },
    {
      "role": "api_object",
      "path": "api/v1.6/measured-dmd-evidence/cleanroom-reproducibility.json",
      "href": "/resource/api/v1.6/measured-dmd-evidence/cleanroom-reproducibility.json",
      "size_bytes": 10941,
      "sha256": "e011356d1d8cbc8dcd09e5343bca0286163132174220565612b195f230a8eff5"
    },
    {
      "role": "api_summary",
      "path": "api/v1.6/measured-dmd-evidence/summary.json",
      "href": "/resource/api/v1.6/measured-dmd-evidence/summary.json",
      "size_bytes": 2748,
      "sha256": "b3b7a12eb233abd1dc5f1c24445c6eba83e5942af0a31e11ac424e4e29f2c904"
    }
  ],
  "candidate_dmd_response_truth": "0/21",
  "formal_v1_release": false,
  "submission_ready": false,
  "claim_boundary": {
    "allowed": "Measured DMD-locus induction/correction and sample-level external disease pathway replication with explicit small-n limitations.",
    "blocked": "Candidate-gene response prediction in DMD cells, therapeutic efficacy, patient-level simulation and clinical decision support."
  }
}