# GSE288958 sample-aware context object

- Object ID: `CONTEXT:GSE288958:SAMPLE_AWARE_MODULE:1.1`
- Status: **CITABLE_BOUNDED_REFERENCE_CONTEXT_INDEPENDENT_AUDITS_COMPLETE**
- Checked: 2026-08-12T18:15:46+0800

## Scope

DMD/BMD/control muscle sample-aware context reuse from the existing processed reference. The inferential unit is **independent biopsy/sample; cells are nested observations and not independent disease replicates**.

## Denominators

- Raw matrix inventory: **61,189** cells
- Read-only broad QC gate: **59,237** cells
- Pilot RDS: **59,222** cells
- Raw minus pilot: **1,967** cells

## Context policy

- Stable modules retained: **6**
- Unstable module excluded: `macrophage_monocyte:TLR2_NOD2_sensing`
- Candidate context-only alignments: **ADAM10, CPEB1**
- Normal_2 remains in all-sample summaries and is excluded only in the predeclared sensitivity rerun.
- Donor-wise Scrublet and the independent annotation-disagreement audit are linked through `GSE288958:REFERENCE-AUDIT:20260909:1`.

## Claim boundary

This object supports bounded descriptive, sample-aware module context with predeclared Normal_2, independent Scrublet and annotation-disagreement sensitivities. It does not support disease-effect p-values, causal inference, model-training labels, therapeutic efficacy, author-exact reprocessing, formal ambient-RNA clearance or direct DMD perturbation truth.

Direct DMD candidate perturbation truth remains **0/21**.