gene experimental_rank priority_tier experimental_role mechanism_axis candidate_context_decision context_overlay_status supporting_context_modules context_celltypes all_samples_delta normal2_excluded_delta direction_stability stable_module_count stable_module_sample_rows stable_module_sample_count stable_module_flagged_samples qc_context_gate_state normal2_sensitivity_required training_label_allowed disease_effect_testing_authorized direct_dmd_perturbation_truth experimental_rank_preserved candidate_score_changed external_context_evidence_scope candidate_claim_ceiling model_output_changed mapping_rationale excluded_unstable_context ADAM10 1 A primary_rescue membrane shedding / Notch / adhesion SUPPORTIVE_STABLE_MODULE_CONTEXT SUPPORTIVE_CONTEXT_ALIGNMENT_NOT_GENE_VALIDATED satellite_myogenic:regeneration_stress satellite_myogenic satellite_myogenic:regeneration_stress=0.025550 satellite_myogenic:regeneration_stress=0.028070 PRESERVED_AFTER_NORMAL_2_EXCLUSION 1 11 11 Normal_2 DESCRIPTIVE_ONLY_NORMAL_2_SENSITIVITY TRUE FALSE FALSE FALSE TRUE FALSE MODULE_LEVEL_CONTEXT_ONLY L2_CONTEXT_TRIAGE_ONLY FALSE Existing ranking links ADAM10 to muscle Notch/satellite-cell biology; the reference satellite regeneration-stress module is direction-stable. macrophage_monocyte:TLR2_NOD2_sensing CALR 2 A primary_rescue ER proteostasis / calcium handling NO_DIRECT_STABLE_MODULE_MAPPING NOT_MAPPED_NO_DIRECT_GENE_MODULE_LINK NOT_ASSESSED 0 0 0 DESCRIPTIVE_ONLY_NORMAL_2_SENSITIVITY TRUE FALSE FALSE FALSE TRUE FALSE MODULE_LEVEL_CONTEXT_ONLY NO_GENE_LEVEL_CONTEXT_CLAIM FALSE No direct candidate-to-reference-module link was documented in the existing ranking evidence; no context support is assigned. macrophage_monocyte:TLR2_NOD2_sensing MPHOSPH6 3 A primary_rescue nuclear RNA exosome / RNA surveillance NO_DIRECT_STABLE_MODULE_MAPPING NOT_MAPPED_NO_DIRECT_GENE_MODULE_LINK NOT_ASSESSED 0 0 0 DESCRIPTIVE_ONLY_NORMAL_2_SENSITIVITY TRUE FALSE FALSE FALSE TRUE FALSE MODULE_LEVEL_CONTEXT_ONLY NO_GENE_LEVEL_CONTEXT_CLAIM FALSE No direct candidate-to-reference-module link was documented in the existing ranking evidence; no context support is assigned. macrophage_monocyte:TLR2_NOD2_sensing ZNF236 4 B high_information_contrast transcriptional phenotype / candidate ribosome-biogenesis regulator NO_DIRECT_STABLE_MODULE_MAPPING NOT_MAPPED_NO_DIRECT_GENE_MODULE_LINK NOT_ASSESSED 0 0 0 DESCRIPTIVE_ONLY_NORMAL_2_SENSITIVITY TRUE FALSE FALSE FALSE TRUE FALSE MODULE_LEVEL_CONTEXT_ONLY NO_GENE_LEVEL_CONTEXT_CLAIM FALSE No direct candidate-to-reference-module link was documented in the existing ranking evidence; no context support is assigned. macrophage_monocyte:TLR2_NOD2_sensing CPEB1 5 B muscle_mechanism_contrast cytoplasmic polyadenylation / MYOD1 translation SUPPORTIVE_STABLE_MODULE_CONTEXT SUPPORTIVE_CONTEXT_ALIGNMENT_NOT_GENE_VALIDATED satellite_myogenic:regeneration_stress satellite_myogenic satellite_myogenic:regeneration_stress=0.025550 satellite_myogenic:regeneration_stress=0.028070 PRESERVED_AFTER_NORMAL_2_EXCLUSION 1 11 11 Normal_2 DESCRIPTIVE_ONLY_NORMAL_2_SENSITIVITY TRUE FALSE FALSE FALSE TRUE FALSE MODULE_LEVEL_CONTEXT_ONLY L2_CONTEXT_TRIAGE_ONLY FALSE Existing ranking links CPEB1 to MYOD1 translation and muscle-regeneration biology; the reference satellite regeneration-stress module is direction-stable. macrophage_monocyte:TLR2_NOD2_sensing EPS8L1 6 B transfer_contrast RAC-linked actin remodeling NO_DIRECT_STABLE_MODULE_MAPPING NOT_MAPPED_NO_DIRECT_GENE_MODULE_LINK NOT_ASSESSED 0 0 0 DESCRIPTIVE_ONLY_NORMAL_2_SENSITIVITY TRUE FALSE FALSE FALSE TRUE FALSE MODULE_LEVEL_CONTEXT_ONLY NO_GENE_LEVEL_CONTEXT_CLAIM FALSE No direct candidate-to-reference-module link was documented in the existing ranking evidence; no context support is assigned. macrophage_monocyte:TLR2_NOD2_sensing INTS13 7 B discordance_contrast Integrator enhancer module / lineage transcription NO_DIRECT_STABLE_MODULE_MAPPING NOT_MAPPED_NO_DIRECT_GENE_MODULE_LINK NOT_ASSESSED 0 0 0 DESCRIPTIVE_ONLY_NORMAL_2_SENSITIVITY TRUE FALSE FALSE FALSE TRUE FALSE MODULE_LEVEL_CONTEXT_ONLY NO_GENE_LEVEL_CONTEXT_CLAIM FALSE No direct candidate-to-reference-module link was documented in the existing ranking evidence; no context support is assigned. macrophage_monocyte:TLR2_NOD2_sensing RAC3 8 B cytoskeleton_contrast Rho-family actin / adhesion signaling NO_DIRECT_STABLE_MODULE_MAPPING NOT_MAPPED_NO_DIRECT_GENE_MODULE_LINK NOT_ASSESSED 0 0 0 DESCRIPTIVE_ONLY_NORMAL_2_SENSITIVITY TRUE FALSE FALSE FALSE TRUE FALSE MODULE_LEVEL_CONTEXT_ONLY NO_GENE_LEVEL_CONTEXT_CLAIM FALSE No direct candidate-to-reference-module link was documented in the existing ranking evidence; no context support is assigned. macrophage_monocyte:TLR2_NOD2_sensing DNM1 9 C exploratory dynamin-dependent membrane fission NO_DIRECT_STABLE_MODULE_MAPPING NOT_MAPPED_NO_DIRECT_GENE_MODULE_LINK NOT_ASSESSED 0 0 0 DESCRIPTIVE_ONLY_NORMAL_2_SENSITIVITY TRUE FALSE FALSE FALSE TRUE FALSE MODULE_LEVEL_CONTEXT_ONLY NO_GENE_LEVEL_CONTEXT_CLAIM FALSE No direct candidate-to-reference-module link was documented in the existing ranking evidence; no context support is assigned. macrophage_monocyte:TLR2_NOD2_sensing GFOD2 10 C exploratory poorly characterized oxidoreductase-like protein NO_DIRECT_STABLE_MODULE_MAPPING NOT_MAPPED_NO_DIRECT_GENE_MODULE_LINK NOT_ASSESSED 0 0 0 DESCRIPTIVE_ONLY_NORMAL_2_SENSITIVITY TRUE FALSE FALSE FALSE TRUE FALSE MODULE_LEVEL_CONTEXT_ONLY NO_GENE_LEVEL_CONTEXT_CLAIM FALSE No direct candidate-to-reference-module link was documented in the existing ranking evidence; no context support is assigned. macrophage_monocyte:TLR2_NOD2_sensing MON1A 11 C exploratory Rab7 activation / endolysosomal maturation NO_DIRECT_STABLE_MODULE_MAPPING NOT_MAPPED_NO_DIRECT_GENE_MODULE_LINK NOT_ASSESSED 0 0 0 DESCRIPTIVE_ONLY_NORMAL_2_SENSITIVITY TRUE FALSE FALSE FALSE TRUE FALSE MODULE_LEVEL_CONTEXT_ONLY NO_GENE_LEVEL_CONTEXT_CLAIM FALSE No direct candidate-to-reference-module link was documented in the existing ranking evidence; no context support is assigned. macrophage_monocyte:TLR2_NOD2_sensing EHMT2 12 C mechanism_negative_control H3K9 methylation / chromatin repression NO_DIRECT_STABLE_MODULE_MAPPING NOT_MAPPED_NO_DIRECT_GENE_MODULE_LINK NOT_ASSESSED 0 0 0 DESCRIPTIVE_ONLY_NORMAL_2_SENSITIVITY TRUE FALSE FALSE FALSE TRUE FALSE MODULE_LEVEL_CONTEXT_ONLY NO_GENE_LEVEL_CONTEXT_CLAIM FALSE No direct candidate-to-reference-module link was documented in the existing ranking evidence; no context support is assigned. macrophage_monocyte:TLR2_NOD2_sensing DDX19B 13 D failure_mode_calibration mRNA export termination / RNA remodeling NO_DIRECT_STABLE_MODULE_MAPPING NOT_MAPPED_NO_DIRECT_GENE_MODULE_LINK NOT_ASSESSED 0 0 0 DESCRIPTIVE_ONLY_NORMAL_2_SENSITIVITY TRUE FALSE FALSE FALSE TRUE FALSE MODULE_LEVEL_CONTEXT_ONLY NO_GENE_LEVEL_CONTEXT_CLAIM FALSE No direct candidate-to-reference-module link was documented in the existing ranking evidence; no context support is assigned. macrophage_monocyte:TLR2_NOD2_sensing NAGLU 14 D failure_mode_calibration lysosomal heparan-sulfate degradation NO_DIRECT_STABLE_MODULE_MAPPING NOT_MAPPED_NO_DIRECT_GENE_MODULE_LINK NOT_ASSESSED 0 0 0 DESCRIPTIVE_ONLY_NORMAL_2_SENSITIVITY TRUE FALSE FALSE FALSE TRUE FALSE MODULE_LEVEL_CONTEXT_ONLY NO_GENE_LEVEL_CONTEXT_CLAIM FALSE No direct candidate-to-reference-module link was documented in the existing ranking evidence; no context support is assigned. macrophage_monocyte:TLR2_NOD2_sensing WDR4 15 D failure_mode_calibration METTL1-WDR4 tRNA m7G methylation NO_DIRECT_STABLE_MODULE_MAPPING NOT_MAPPED_NO_DIRECT_GENE_MODULE_LINK NOT_ASSESSED 0 0 0 DESCRIPTIVE_ONLY_NORMAL_2_SENSITIVITY TRUE FALSE FALSE FALSE TRUE FALSE MODULE_LEVEL_CONTEXT_ONLY NO_GENE_LEVEL_CONTEXT_CLAIM FALSE No direct candidate-to-reference-module link was documented in the existing ranking evidence; no context support is assigned. macrophage_monocyte:TLR2_NOD2_sensing RNF8 16 D failure_mode_calibration DNA-damage histone ubiquitylation NO_DIRECT_STABLE_MODULE_MAPPING NOT_MAPPED_NO_DIRECT_GENE_MODULE_LINK NOT_ASSESSED 0 0 0 DESCRIPTIVE_ONLY_NORMAL_2_SENSITIVITY TRUE FALSE FALSE FALSE TRUE FALSE MODULE_LEVEL_CONTEXT_ONLY NO_GENE_LEVEL_CONTEXT_CLAIM FALSE No direct candidate-to-reference-module link was documented in the existing ranking evidence; no context support is assigned. macrophage_monocyte:TLR2_NOD2_sensing RNASEH2C 17 D failure_mode_calibration RNase H2 / ribonucleotide and R-loop removal NO_DIRECT_STABLE_MODULE_MAPPING NOT_MAPPED_NO_DIRECT_GENE_MODULE_LINK NOT_ASSESSED 0 0 0 DESCRIPTIVE_ONLY_NORMAL_2_SENSITIVITY TRUE FALSE FALSE FALSE TRUE FALSE MODULE_LEVEL_CONTEXT_ONLY NO_GENE_LEVEL_CONTEXT_CLAIM FALSE No direct candidate-to-reference-module link was documented in the existing ranking evidence; no context support is assigned. macrophage_monocyte:TLR2_NOD2_sensing ZFP69B 18 E low_priority_calibration poorly characterized zinc-finger regulation NO_DIRECT_STABLE_MODULE_MAPPING NOT_MAPPED_NO_DIRECT_GENE_MODULE_LINK NOT_ASSESSED 0 0 0 DESCRIPTIVE_ONLY_NORMAL_2_SENSITIVITY TRUE FALSE FALSE FALSE TRUE FALSE MODULE_LEVEL_CONTEXT_ONLY NO_GENE_LEVEL_CONTEXT_CLAIM FALSE No direct candidate-to-reference-module link was documented in the existing ranking evidence; no context support is assigned. macrophage_monocyte:TLR2_NOD2_sensing DNAAF3 19 E low_priority_calibration axonemal-dynein preassembly NO_DIRECT_STABLE_MODULE_MAPPING NOT_MAPPED_NO_DIRECT_GENE_MODULE_LINK NOT_ASSESSED 0 0 0 DESCRIPTIVE_ONLY_NORMAL_2_SENSITIVITY TRUE FALSE FALSE FALSE TRUE FALSE MODULE_LEVEL_CONTEXT_ONLY NO_GENE_LEVEL_CONTEXT_CLAIM FALSE No direct candidate-to-reference-module link was documented in the existing ranking evidence; no context support is assigned. macrophage_monocyte:TLR2_NOD2_sensing LMO2 20 E safety_calibration hematopoietic / endothelial transcriptional cofactor NO_DIRECT_STABLE_MODULE_MAPPING NOT_MAPPED_NO_DIRECT_GENE_MODULE_LINK NOT_ASSESSED 0 0 0 DESCRIPTIVE_ONLY_NORMAL_2_SENSITIVITY TRUE FALSE FALSE FALSE TRUE FALSE MODULE_LEVEL_CONTEXT_ONLY NO_GENE_LEVEL_CONTEXT_CLAIM FALSE No direct candidate-to-reference-module link was documented in the existing ranking evidence; no context support is assigned. macrophage_monocyte:TLR2_NOD2_sensing ZNF133 21 E historical_negative_control KRAB zinc-finger transcriptional repression NO_DIRECT_STABLE_MODULE_MAPPING NOT_MAPPED_NO_DIRECT_GENE_MODULE_LINK NOT_ASSESSED 0 0 0 DESCRIPTIVE_ONLY_NORMAL_2_SENSITIVITY TRUE FALSE FALSE FALSE TRUE FALSE MODULE_LEVEL_CONTEXT_ONLY NO_GENE_LEVEL_CONTEXT_CLAIM FALSE No direct candidate-to-reference-module link was documented in the existing ranking evidence; no context support is assigned. macrophage_monocyte:TLR2_NOD2_sensing