NMD-VCell Neuromuscular Virtual Cell Research Platform Module: Models · Evidence → perturbation → experiment → outcome NMD = neuromuscular disorders

Release 2026.08DMD context observedDMD candidate-conditioned prediction not yet eligible

View scientific status
Evidence freeze: 3 August 2026 Resource: v1.2.0-measured-dmd-evidence Schema: 1.1 Open release status →

← ModelRun & Audit Registry

ModelRun Release · immutable execution history

GEARS

This page publishes the frozen task, result, baseline decision, provenance receipt and prohibited uses for one completed run—including failed and no-go results.

01Frozen dataNMDVCELL-HEPG2-CRISPRI
02Task & splitG0 · five-frozen-target-splits-20260712-20260716
03Baseline comparisonOFFICIAL_NEGATIVE_CONTROL
04FAILOFFICIAL_NEGATIVE_CONTROL

Frozen task receipt

What was evaluated

Model
EXTERNAL-GEARS-0.1.2 · 0.1.2
Biological context
Processed HepG2 CRISPRi perturbation-response substrate
Task
G0
Data release
NMDVCELL-HEPG2-CRISPRI
Split
five-frozen-target-splits-20260712-20260716
Execution status
COMPLETED

Decision receipt

FAIL

No deep-model superiority over the permanent ridge baseline.

Decision state
OFFICIAL NEGATIVE CONTROL
Baseline result
Failed paired RMSE and raw directional support in all five splits; ridge won every direct same-coverage comparison after Holm correction.
Promoted
No
Next action
Retain as an official negative control; do not promote a superiority claim.

Released result

Metrics retained in this ModelRun

Five-seed completion note and released per-seed summary, gates and same-coverage comparison.

MetricValue
test gene counts[534,534,526,532,535]

Quickstart · reproduction receipt

PARTIAL REPRODUCTION RECEIPT

This is an audit-first quickstart. It exposes the exact JSON, known prerequisites and missing receipts; it does not invent a runnable command when code, container, data or seeds are absent.

Responsible use

Prohibited claims

  • No calibrated DMD prediction.
  • No DMD disease-response prediction.
  • No therapeutic or clinical use.
  • Do not inherit performance from the model family or an external publication.

Associated resources

Follow the result into the next decision.

Claim boundary

Completed does not mean clinically or biologically qualified.

Retain as an official negative control; do not promote a superiority claim.