NMD-VCell Disease Virtual Cell Platform Specify a cell-state question, inspect computability, and design the missing test Module: Predict · evidence-to-experiment workflow NMD = neuromuscular disorders

Current limit: the site can compare existing evidence, but no candidate has yet been independently repeated in a DMD muscle model.

Research evidence only 21 prioritized candidate perturbation records 2,160 benchmark perturbation targets 0 independent DMD replications Boundary & release
21 Workbench candidates are surfaced for consideration, not ranked as validated targets 2,160 target-level perturbation responses form the frozen HepG2 benchmark substrate No validated DMD perturbation prediction v1.0.0-database-resource Frozen 25 Jul 2026 Schema 1.1 Model ridge-safe-v2.3 Benchmark repeated-fold-v2.2 Build EA-20260730-42 DOI pending Open evidence boundary →

Model Card Audit

Patient trajectory model

This card states exactly what the model was allowed to learn, predict, evaluate and claim in this release. Architecture labels and external publications do not create local DMD prediction performance.

NMDVCELL-PATIENT-TRAJECTORY-FUTURElocked not trained or not executed

Input, output and current result

InputRequired longitudinal patient-linked cell state, intervention and outcome data
OutputDesired patient-specific trajectory and intervention response with uncertainty
Training context
No patient-linked longitudinal perturbation trajectory
Held-out task
Required prospective patient and site holdout
Current result
No patient-specific trajectory or treatment simulation is permitted.
Permitted use
Research roadmap only; no clinical decision support

Audit axes

The model is reviewed across twelve required axes.

No scalar model score
Permanent baselines
  • natural-history and population-level reference models
Primary metrics
  • prospective calibration
  • safety
  • subgroup performance
  • clinical utility
Leakage control

registered_requirement_no_executed_split

Calibration / OOD

not_calibrated_for_dmd_response · not_validated_for_dmd_muscle_or_patient_context

Claim boundary

What this model card does not authorize

Unlock rule: Requires longitudinal data, prospective evaluation, privacy safeguards and clinical governance. Automatic unlock is disabled.