NMD-VCell Neuromuscular Virtual Cell Research Platform Module: Models · Evidence → perturbation → experiment → outcome NMD = neuromuscular disorders

Release 2026.08DMD context observedDMD candidate-conditioned prediction not yet eligible

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Evidence freeze: 3 August 2026 Resource: v1.2.0-measured-dmd-evidence Schema: 1.1 Open release status →

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ModelRun Release · immutable execution history

MORPH DepMap-25Q3 validation pilot

This page publishes the frozen task, result, baseline decision, provenance receipt and prohibited uses for one completed run—including failed and no-go results.

01Frozen dataDEPMAP-25Q3-MORPH-PILOT
02Task & splitG0-VALIDATION-PILOT · 64-train-16-validation-v27-test-sealed
03Baseline comparisonVALIDATION_ONLY_NEGATIVE_CONTROL
04NO_GOSCIENTIFIC_NO_GO_TEST_SEALED

Frozen task receipt

What was evaluated

Model
EXTERNAL-MORPH-1AD06D4 · source-1ad06d4
Biological context
Deterministic HepG2 perturbation pilot with DepMap Public 25Q3 gene embeddings
Task
G0-VALIDATION-PILOT
Data release
DEPMAP-25Q3-MORPH-PILOT
Split
64-train-16-validation-v27-test-sealed
Execution status
COMPLETED

Decision receipt

NO_GO

Engineering passed, but the model did not beat the simple train-mean baseline.

Decision state
SCIENTIFIC NO GO TEST SEALED
Baseline result
Reduced MSE by 0.92% versus zero but was 34.13% worse than train mean; beat train mean on only 2 of 16 validation conditions.
Promoted
No
Next action
Keep the v27 test partition sealed; any revision needs a fresh validation contract.

Released result

Metrics retained in this ModelRun

Independent verifier reproduced the checkpoint, sampler state and every condition-level metric.

MetricValue
validation conditions16
morph delta mse0.014162
train mean delta mse0.010558
zero delta mse0.014293
relative worsening vs train mean0.3413

Quickstart · reproduction receipt

PARTIAL REPRODUCTION RECEIPT

This is an audit-first quickstart. It exposes the exact JSON, known prerequisites and missing receipts; it does not invent a runnable command when code, container, data or seeds are absent.

Source artifacts

Associated execution evidence

  • No public source-artifact route is registered for this run.

Runtime note: PyTorch 2.5.1+cu121; NVIDIA V100 32GB; 10 epochs

Responsible use

Prohibited claims

  • No calibrated DMD prediction.
  • No DMD disease-response prediction.
  • No therapeutic or clinical use.
  • Do not inherit performance from the model family or an external publication.

Associated resources

Follow the result into the next decision.

Claim boundary

Completed does not mean clinically or biologically qualified.

Keep the v27 test partition sealed; any revision needs a fresh validation contract.