{
  "card_schema": "nmd-vcell-model-card-audit/1.0",
  "interface_build": "EA-20260730-42",
  "resource_release": "v1.0.0-database-resource",
  "evidence_freeze": "2026-07-25",
  "model_id": "NMDVCELL-DMD-TRANSITION-FUTURE",
  "model_card_slug": "nmdvcell-dmd-transition-future",
  "stable_url": "/resource/models/nmdvcell-dmd-transition-future/",
  "json_url": "/resource/api/v1.1/model-cards/nmdvcell-dmd-transition-future.json",
  "name": "Disease-conditioned state-transition model",
  "model_family": "future conditional population model",
  "lifecycle_state": "LOCKED_NO_TRAINING_TRUTH",
  "state": "locked",
  "status": "Not trained",
  "execution_state": "locked_not_trained_or_not_executed",
  "input": "Required matched DMD/control myogenic perturbations with donor, state, time and function",
  "output": "Desired molecular response, state transition, functional effect, toxicity and calibrated uncertainty",
  "training_context": "No qualifying disease-relevant perturbation training set",
  "held_out_task": "Planned unseen donor · state · laboratory · disease line · G2–G6",
  "permanent_baselines": [
    "zero change",
    "train mean",
    "ridge",
    "nearest-neighbour transfer"
  ],
  "primary_metrics": [
    "DES",
    "PDS",
    "MAE",
    "calibration",
    "AUPRC",
    "hit rate",
    "replication",
    "abstention"
  ],
  "current_result": "No calibrated DMD state-transition prediction is emitted.",
  "permitted_use": "Architecture and evaluation contract only",
  "unlock_condition": "Return independent DMD perturbation outcomes through frozen Study, Prediction and Outcome objects.",
  "audit_axes": [
    {
      "axis": "model_identity",
      "status": "declared_locked_no_current_result"
    },
    {
      "axis": "training_data_context",
      "status": "declared_locked_no_current_result"
    },
    {
      "axis": "input_feature_space",
      "status": "declared_locked_no_current_result"
    },
    {
      "axis": "output_estimand",
      "status": "declared_locked_no_current_result"
    },
    {
      "axis": "held_out_task_and_split",
      "status": "declared_locked_no_current_result"
    },
    {
      "axis": "permanent_baselines",
      "status": "declared_locked_no_current_result"
    },
    {
      "axis": "primary_metrics",
      "status": "declared_locked_no_current_result"
    },
    {
      "axis": "current_result_or_locked_state",
      "status": "declared_locked_no_current_result"
    },
    {
      "axis": "leakage_and_grouping_controls",
      "status": "declared_locked_no_current_result"
    },
    {
      "axis": "calibration_uncertainty_and_abstention",
      "status": "declared_locked_no_current_result"
    },
    {
      "axis": "permitted_and_prohibited_uses",
      "status": "declared_locked_no_current_result"
    },
    {
      "axis": "unlock_condition",
      "status": "declared_locked_no_current_result"
    }
  ],
  "data_contract": {
    "training_data_context": "No qualifying disease-relevant perturbation training set",
    "input_feature_space": "Required matched DMD/control myogenic perturbations with donor, state, time and function",
    "output_estimand": "Desired molecular response, state transition, functional effect, toxicity and calibrated uncertainty",
    "disease_context_coverage": "required_for_future_dmd_task_not_available",
    "traceable_training_freeze": "not_available_no_training_truth"
  },
  "evaluation_contract": {
    "held_out_task": "Planned unseen donor · state · laboratory · disease line · G2–G6",
    "permanent_baselines": [
      "zero change",
      "train mean",
      "ridge",
      "nearest-neighbour transfer"
    ],
    "primary_metrics": [
      "DES",
      "PDS",
      "MAE",
      "calibration",
      "AUPRC",
      "hit rate",
      "replication",
      "abstention"
    ],
    "current_result": "No calibrated DMD state-transition prediction is emitted.",
    "evaluation_status": "not_executed_locked",
    "result_promotes_dmd_prediction_claim": false
  },
  "leakage_and_split_audit": {
    "grouping_policy": "Prediction claims require split grouping by perturbation target, donor or disease line as appropriate to the task.",
    "current_grouping_status": "registered_requirement_no_executed_split",
    "leakage_risk_if_overclaimed": "high_if_architecture_is_treated_as_a_result"
  },
  "calibration_uncertainty_and_abstention": {
    "calibration_status": "not_calibrated_for_dmd_response",
    "uncertainty_status": "not_available",
    "ood_status": "not_validated_for_dmd_muscle_or_patient_context",
    "abstention_status": "required_before_any_future_prediction_release"
  },
  "claim_boundary": {
    "platform_level": "P0_prediction_infrastructure_only",
    "dmd_prediction_claim": "locked_no_dmd_perturbation_truth",
    "calibrated_dmd_prediction": false,
    "clinical_decision_support": false,
    "external_model_performance_inherited": false,
    "permitted_use": "Architecture and evaluation contract only",
    "prohibited_claims": [
      "validated_dmd_disease_response_prediction",
      "therapeutic_efficacy_or_safety_prediction",
      "patient_specific_or_clinical_decision_support",
      "performance_inherited_from_external_foundation_models"
    ]
  },
  "unlock_path": {
    "next_required_evidence": "Return independent DMD perturbation outcomes through frozen Study, Prediction and Outcome objects.",
    "must_return_through": [
      "registered_studies.json",
      "prediction_registry.json",
      "experimental_outcomes.json",
      "model_card_audit_registry.json"
    ],
    "automatic_unlock": false
  },
  "linked_objects": {
    "model_registry": "/resource/api/v1.1/model_registry.json",
    "model_card_schema": "/resource/api/v1.1/model_card.schema.json",
    "benchmark_suite": "/resource/api/v1.1/benchmark_suite.json",
    "prediction_readiness": "/resource/api/v1.1/prediction_readiness.json",
    "prediction_registry": "/resource/api/v1.1/prediction_registry.json"
  }
}