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NMD-VCell Research OSDisease state → cell state → target → experiment
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Release 2026.08DMD context observedDMD candidate-conditioned prediction not yet eligible
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Evidence freeze: 3 August 2026Resource: v1.2.0-measured-dmd-evidenceSchema: 1.1Open release status
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Gene evidence summary

GFOD2

Current recommendation: Pause until the external evidence is audited.

What we know

GFOD2 was experimentally perturbed in HepG2 cells.

What remains uncertain

Different DMD datasets do not fully agree on the disease-associated direction. A matched perturbation in a DMD-relevant muscle model is the truth needed to calibrate a future DMD-response model.

What should happen next

Pause until the external evidence is audited. Use independent reagents and biological replication, and predeclare one functional endpoint.

Current value: this record identifies the most informative next experiment and the result needed for model calibration. It does not yet establish a therapeutic or clinical conclusion.

Design this experimentReview research evidenceCompare evidenceOpen core data

Evidence journey

Where GFOD2 stands—and what creates the next evidence

Read left to right from released knowledge to translation. The highlighted next step is a research decision, not a target score.

Inspect datasets and methods →
01 · Database supportVersioned gene recordStable identity, provenance and downloadable evidence are available.
02 · Disease contextDMD context assembledSource-specific DMD signals are retained separately for interpretation.
03 · Model evidenceCalibration truth neededThe current evidence defines what a future DMD-response model must learn and test.
04 · Experimental perturbationObserved outside DMD muscleThe HepG2 response is useful for context transfer, not yet DMD truth.
05 · Functional phenotypeNext decision experimentPause until the external evidence is audited
06 · Clinical evidenceFuture translation layerClinical interpretation follows reproducible disease-matched functional evidence.

Data behind this summary

Exact values currently available for GFOD2

These values come from different biological contexts and are displayed separately. They are not combined into one target score.

Open all dataset rows →
HepG2 perturbation coverage127 cellsCells in the frozen aggregate; not biological replicates.
Skeletal-muscle expression2.94732 TPMGTEx v8 tissue-expression context; not perturbation evidence.
DMD source effects2/4 directions agree4 source-specific effects retained without pooling.
Human-myoblast fusion screenNot assessedMissing is not a negative result.

What this candidate is for

Can the reported external GFOD2 evidence be reproduced from traceable quantitative data and provenance?

A candidate record authorizes a bounded question and next experiment. It does not authorize a therapeutic or clinical claim.

Practical useDecide whether an external report is strong enough to change the governed evidence state.
Decision available nowKeep the current status unchanged until the external result is imported and audited.
What blocks itExternal quantitative evidence has not been imported and audited
Minimum next actionImport the GFOD2 estimates, denominators, analysis rules and provenance, then reproduce the conclusion.
How would the result change the decision?

SupportiveReassign the candidate through the evidence-transition rules only if the quantitative result and provenance reproduce.

NullKeep the hold and retain the failed audit as evidence if the report cannot be reproduced.

Inconclusive / QC failureKeep the report unassessed when essential files or metadata are unavailable.

Open Study CardPlan the experimentCompare decision gaps

Plain view presents the current story. Open Research for evidence details or Audit for machine fields and provenance.