NMD-VCell Neuromuscular Virtual Cell Research Platform Module: Data · Evidence → perturbation → experiment → outcome NMD = neuromuscular disorders
For Reviewers Current Release
Science & reproducibility
Advanced workspace Current release Scientific program Methods & reproducibility Evidence governance Evidence freeze: 3 August 2026
Available nowExplore disease contextInspect gene evidenceAudit model runsDesign experimentsProspective DMD outcome is nextCheck computability
Evidence Release 2026.08 Measured DMD context Truth-generation study is the next milestone Prediction validation follows model eligibility Archive identity awaiting external authorization Release status →
Evidence details 21 governed candidate records 2,160 benchmark perturbation targets 250 observed human-myoblast fusion hits Expand
21 prespecified hypotheses are governed records; no current target ranking is generated 2,160 target-level perturbation responses form the frozen HepG2 benchmark substrate GSE293514 Stage B0 contributes 250 healthy-human-myoblast fusion hits and 125 individually validated genes Measured DMD disease context is available; direct candidate-level DMD perturbation outcomes are not yet available v1.2.0-measured-dmd-evidence Frozen 3 August 2026 Schema 1.1 Model ridge-safe-v2.3 Benchmark repeated-fold-v2.2 Build EA-20260817-57 DOI pending Evidence boundary → Full audit view →

Frozen representative query · NAR review mode

ZNF133

A version-locked replay of the representative gene query used in the database-paper figure. Values below come from v1.0.0-database-resource, not the live successor.

Open query JSONReturn to frozen snapshotOpen current Study Card renderer
Interpretation boundary: this query preserves measured context and explicit missingness. It does not predict a DMD response or identify a therapeutic target.

Context-preserving evidence

The answer is a structured evidence state, not a score.

Observed HepG2 aggregate

84 cells

Same-context perturbation evidence retained with its native denominator.

Skeletal-muscle expression

4.55781 TPM

Expression context only; not perturbation validation.

GSE293514 fusion screen

not a hit

log fold-change −0.003533; FDR 0.999999. This assessed screen does not establish a general null effect.

DMD source direction

3/4 · conflicted

Source disagreement remains visible and is not pooled into disease ground truth.

Healthy-myoblast network

explicit no edge

No released fusion-defect edge for this endpoint; missing coverage is not a negative biological result.

Next measurement

muscle-context assay

GAP-02: independent muscle-context perturbation is absent.

What a first-time reviewer should conclude

NMD-VCell can retrieve a stable record, preserve source context, expose disagreement, return an explicit no-edge state and connect the blocking gap to a draft experiment. It cannot infer efficacy, safety, therapeutic priority or a calibrated DMD perturbation response from this record.