Cell Context Explorer
Filter ten released context records across DMD, FSHD, DM1 and SMA, then use the DMD ecosystem map to translate evidence coverage into the next testable cell-system question.
Module meaning contract
Next handoffOpen a gene record, compare DMD candidates, or return to a disease module for disease-level evidence. Continue →
Measured-context inventory
Each record names the dataset, analysis unit, observed result, permitted use and the highest claim it can support. Missing target-context outcome remains visible as a record.
CTX-DMD-MYOGENIC-CORRECTION
Permitted use: DMD induction and locus-correction reference
Claim ceiling: No candidate-gene response prediction
Open the source-bounded module →CTX-DMD-PATIENT-MUSCLE
Permitted use: External disease-pathway replication
Claim ceiling: No candidate-gene perturbation efficacy
Open the source-bounded module →CTX-DMD-CANDIDATE-PERTURBATION
Permitted use: Study design and predictability gating only
Claim ceiling: Prediction locked; absence is not a negative effect
Open the source-bounded module →CTX-FSHD-PATIENT-MYOTUBE
Permitted use: Descriptive state stratification
Claim ceiling: No donor-general or patient treatment estimate
Open the source-bounded module →CTX-FSHD-IDUX4
Permitted use: DUX4-response timing and experiment design
Claim ceiling: Cell-line response, not patient therapeutic efficacy
Open the source-bounded module →CTX-DM1-ISOGENIC-MYOBLAST
Permitted use: Expression and splicing correction reference
Claim ceiling: Clones are not independent patients
Open the source-bounded module →CTX-DM1-PATIENT-MUSCLE
Permitted use: Patient expression/splicing comparison
Claim ceiling: No prognosis or treatment ranking
Open the source-bounded module →CTX-SMA-SPINAL-ORGANOID
Permitted use: Human neural intervention-response design
Claim ceiling: No patient motor-outcome prediction
Open the source-bounded module →CTX-SMA-TREATED-MUSCLE
Permitted use: Residual muscle-module experiment design
Claim ceiling: Null threshold result is not proof of full correction
Open the source-bounded module →CTX-SMA-NEURONAL
Permitted use: Cross-neuronal disease-context comparison
Claim ceiling: No calibrated intervention or patient response
Open the source-bounded module →Map layer
Biology shows the role each compartment plays in tissue repair and remodeling.
Carries regeneration, fusion and contractile maturation—the lineage in which a functional DMD perturbation effect must ultimately be tested.
Shapes extracellular matrix and the regenerative niche, making it a plausible mediator of fibrosis and muscle–stroma feedback.
Coordinates injury sensing, inflammatory state and repair signals that may alter regeneration and stromal activation.
Provides perfusion and endothelial support and may participate in tissue remodeling and repair-state communication.
One result · three reading levels
The map is a context-and-readiness ontology. It does not estimate ligand activity, causal cell–cell effects or perturbation-conditioned state transitions.
Each compartment changes the biological question and the readouts that matter. Only the myogenic lineage currently has a measured reference trajectory, and none has a calibrated DMD perturbation response.
Muscle disease involves several kinds of cells working together. The map shows which parts researchers can study now and which still need experiments.
Evidence availability checker
What this means: NMD-VCell can assemble the evidence and define the next experiment, but it cannot yet emit a calibrated DMD response.