{
  "schema": "nmd-vcell-frozen-reviewer-query/1.0",
  "resource_release": "v1.0.0-database-resource",
  "interface_build": "EA-20260802-46",
  "evidence_freeze": "2026-07-25",
  "source_commit": "d93c7c0bcff34673eac5a0f9f9ca127fc1c9a801",
  "query": {
    "entity_type": "gene",
    "value": "ZNF133"
  },
  "result": {
    "highest_supported_level": "L2_observed_same_context_perturbation",
    "highest_assessed_level": "L3a_external_context_screen",
    "observed_hepg2_cell_count": 84,
    "skeletal_muscle_expression_tpm": 4.55781,
    "myoblast_fusion_screen": {
      "source": "GSE293514",
      "log_fold_change": -0.003533,
      "fdr": 0.999999,
      "hit": false
    },
    "dmd_source_direction": {
      "agreeing_sources": 3,
      "assessed_sources": 4,
      "proportion": 0.75,
      "state": "conflicted"
    },
    "healthy_myoblast_network_lookup": {
      "endpoint": "fusion_defect",
      "state": "explicit_no_edge",
      "interpretation": "No released endpoint-specific edge; this is not evidence of no biological effect."
    },
    "decision_blocking_gap": {
      "code": "GAP-02",
      "label": "Independent muscle-context perturbation is absent"
    },
    "next_action": "Muscle-context assay",
    "study_card_state": "DRAFT",
    "current_numeric_rank": null
  },
  "claim_boundary": [
    "Representative frozen query output; not a home-page screenshot.",
    "The result does not create a target rank, DMD prediction, therapeutic claim or clinical recommendation.",
    "Missing or no-edge coverage is not a negative biological result."
  ]
}