Evidence stress-test module registry

Evidence stress test

Module registry

Eleven computation-first checks, with executed, partial and registered states kept separate.

Module	Question	Independent unit	Current state	Claim impact
NWLE-00	Release and provenance integrity	release object or rendered route	RELEASED EXECUTED	Supports reproducibility of the released resource; it does not support a biological claim.
NWLE-01	Same-context predictive audit	held-out perturbation target within repeated balanced folds	EXECUTED BOUNDED STRICT GATE 0 OF 16	Supports a small same-context RMSE improvement only; strict direct-head support is not established.
NWLE-02	External aggregate transfer diagnostic	external perturbation target	EXECUTED NO DIRECTIONAL TRANSFER SUPPORT	Falsifies a broad directional-transfer claim on the current 55-target panel; it is not DMD or muscle truth.
NWLE-03	Public myogenic and DMD context triangulation	public study, target or reference trajectory	EXECUTED REFERENCE ONLY	Can downgrade or contextualize hypotheses; cannot create independent DMD candidate-perturbation validation.
NWLE-04	Source-balanced DMD prior multiverse	source-aware gene-context estimate	REGISTERED NOT EXECUTED	Will improve disease-prior robustness, but still will not constitute perturbation efficacy.
NWLE-05	Leakage-safe G2 backtest	held-out gene family or pathway	REGISTERED NOT EXECUTED	Required before an unseen-family generalization claim.
NWLE-06	In-silico perturbation-mode boundary	perturbation × context × modality	PARTIAL BOUNDED SIMULATION ONLY	Observed same-HepG2 CRISPRi and additive null previews are usable; KO, overexpression, fate and synergy claims remain locked.
NWLE-07	Uncertainty, OOD and abstention audit	target or context-level prediction	PARTIAL BOOTSTRAP AVAILABLE OOD ABSTENTION NOT TRAINED	Sampling intervals are available for selected executed analyses; trained OOD-aware abstention is not yet supported.
NWLE-08	Retrospective selection-enrichment backtest	outcome-blinded candidate selection set	REGISTERED NOT EXECUTED OUTCOME LEAKAGE GUARD	Only valid when a pre-outcome model snapshot and eligible outcome universe can be proven.
NWLE-09	Independent computational reproduction	independent analyst execution	REGISTERED EXTERNAL REPRODUCTION NOT EXECUTED	Independent reproduction can strengthen computational reliability, but not biological validity.
NWLE-10	UniPert cross-domain representation feasibility	candidate gene, held-out target family or compound scaffold	PARTIAL SOURCE AND IDENTIFIER AUDIT EXECUTED MODEL EVALUATION PENDING	Supports operational feasibility only; no embedding benefit, cross-domain transfer or DMD therapeutic value has been established.

Boundary: these modules can stress-test computational reliability and evidence compatibility. They cannot establish DMD efficacy, function, safety or treatment utility.