{
  "run_schema": "nmd-vcell-model-run/1.0",
  "interface_build": "EA-20260817-57",
  "resource_release": "v1.2.0-measured-dmd-evidence",
  "evidence_freeze": "2026-08-03",
  "run_id": "MRUN-MORPH-DEPMAP25Q3-VALIDATION-20260722",
  "model_id": "EXTERNAL-MORPH-1AD06D4",
  "model_name": "MORPH DepMap-25Q3 validation pilot",
  "model_version": "source-1ad06d4",
  "run_role": "VALIDATION_ONLY_NEGATIVE_CONTROL",
  "execution_status": "COMPLETED",
  "decision_state": "SCIENTIFIC_NO_GO_TEST_SEALED",
  "completed_at": "2026-07-22",
  "completion_date_status": "FROZEN_VALIDATION_REPORT",
  "biological_context": "Deterministic HepG2 perturbation pilot with DepMap Public 25Q3 gene embeddings",
  "task_id": "G0-VALIDATION-PILOT",
  "data_release": "DEPMAP-25Q3-MORPH-PILOT",
  "split_id": "64-train-16-validation-v27-test-sealed",
  "seeds": [
    "20260722"
  ],
  "seed_status": "VALIDATION_COMPLETE_TEST_NOT_OPENED",
  "provenance": {
    "code_revision": "1ad06d4591434cc4ab03c12c461fe0d80b087b11",
    "code_revision_status": "PINNED_CLEAN_OFFICIAL_SOURCE",
    "container_digest": null,
    "container_digest_status": "RUNTIME_RECORDED_CONTAINER_DIGEST_NOT_FROZEN",
    "data_digests": [
      "31bcf5d27f1fe3fcf6c5ff4f2aae8695ee1b03956b4bef786a49633055cc5f75",
      "08efa31e997358e333ead55ed21cbf0f643cfafe15b38a242acaaa11eb0a7962"
    ],
    "runtime": "PyTorch 2.5.1+cu121; NVIDIA V100 32GB; 10 epochs",
    "source_report_path": "reports/V27_MORPH_DEPMAP25Q3_TRAIN_VALIDATION_PILOT_20260722.md",
    "source_report_sha256": "7a0cb26b971fc5b6fd0381890bb773548265acd71d8343c90671b80069402de1"
  },
  "metrics": {
    "validation_conditions": 16,
    "morph_delta_mse": 0.014162,
    "train_mean_delta_mse": 0.010558,
    "zero_delta_mse": 0.014293,
    "relative_worsening_vs_train_mean": 0.3413
  },
  "baseline_comparison": "Reduced MSE by 0.92% versus zero but was 34.13% worse than train mean; beat train mean on only 2 of 16 validation conditions.",
  "gate": {
    "decision": "NO_GO",
    "reason": "Engineering passed, but the model did not beat the simple train-mean baseline.",
    "next_action": "Keep the v27 test partition sealed; any revision needs a fresh validation contract."
  },
  "verification": "Independent verifier reproduced the checkpoint, sampler state and every condition-level metric.",
  "source_artifacts": [],
  "promoted_to_current_model": false,
  "claim_boundary": {
    "calibrated_dmd_prediction": false,
    "dmd_disease_response_prediction": false,
    "therapeutic_or_clinical_use": false
  },
  "stable_url": "/resource/model-run/mrun-morph-depmap25q3-validation-20260722/",
  "json_url": "/resource/api/v1.1/model-runs/mrun-morph-depmap25q3-validation-20260722.json"
}