Help

Task-based help

Five reproducible Evidence Atlas workflows

Each workflow ends in a stable page or downloadable object. Evidence levels are never treatment grades.

1 · How do I evaluate one gene?

1. Open the ZNF133 research record.
2. Read current action, legacy integrated DMD prior, source agreement, source state, prior-variant stability and evidence modules as separate fields.
3. Inspect the evidence ladder and primary gap.
4. Download the typed record for citation or reuse.

2 · How do I compare a candidate list?

Open the frozen example for ZNF133, MON1A and GFOD2. It has a stable object ID, checksum, rendered results, JSON and TSV that work without JavaScript. The interactive Compare form remains a temporary workspace until its output is preserved as an object.

3 · How do I interpret DMD source conflict?

Use DMD Evidence Explorer. “Conflicted” means at least one positive and one negative source-level median. Module membership and nine-variant stability do not replace this field.

4 · How do I generate and cite a Study Card?

Open the ZNF133 muscle-assay card. Cite its gene, card schema, resource release, evidence freeze and interface build; download YAML for preregistration or JSON/TSV for a registry.

5 · What does L2 not mean?

L2 is same-HepG2 observed perturbation or internal model support. It does not mean muscle replication, DMD functional validation, therapeutic rescue, safety or clinical benefit. L3a is an external-context screen; L3b is independent replication of the same perturbation.

Compact glossary

L3a

External-context screen; not same-perturbation replication.

L3b

Same perturbation replicated independently.

L4

DMD-relevant muscle functional validation.

L5

Therapeutic or clinical utility.

Counteralignment

Opposition to the integrated DMD prior; never therapeutic rescue.

Not assessed

Missing coverage, not a negative result.