NMD-VCell Virtual Cell Evidence Engine See what is known, what is uncertain, and what to test next Module: Research Decision Queue · evidence-to-experiment workflow NMD = neuromuscular disorders

Current limit: the site can compare existing evidence, but no candidate has yet been independently repeated in a DMD muscle model.

Research evidence only 21 observed HepG2 perturbations 0 independent DMD replications Boundary & release
Observed HepG2 perturbations with limited external myogenic context No validated DMD perturbation prediction v1.0.0-database-resource Frozen 25 Jul 2026 Schema 1.1 Model ridge-safe-v2.3 Benchmark repeated-fold-v2.2 Build EA-20260730-31 DOI pending Open evidence boundary →

Collaborate

Help close one specific evidence gap.

The platform currently needs traceable DMD perturbation outcomes, auditable external evidence and independent computational reproduction—not more unsupported target claims.

Experimental outcome

DMD or matched-control perturbation data

Submit target, context, modality, reagent, donor, endpoint, QC and result status. Null and failed results are first-class records.

  • Preserve biological and technical replicate identity.
  • Declare target engagement, viability and primary endpoint.
  • Do not collapse reagent or donor discordance.
Download outcome template
External evidence

Quantitative evidence for an existing candidate

Import reported evidence with stable source identifiers, quantitative values, provenance and an explicit permitted interpretation.

  • Use the released data dictionary.
  • Run the validator before review.
  • Import does not equal validation.
Download evidence template
Independent reproduction

Reproduce a released computational result

Run the portable objects independently and report checksum, environment, metric agreement and any discrepancy.

  • Keep the frozen split and baseline definitions.
  • Report failures without relabelling.
  • Computational reproduction does not establish biology.
Open reproducibility package

Review rule

Every contribution remains contextual until its scope, provenance and replication support a transition.

Read transition rules