NMD-VCell Virtual Cell Evidence Engine See what is known, what is uncertain, and what to test next Module: Evidence Atlas · evidence-to-experiment workflow NMD = neuromuscular disorders
Search Data & downloads Release v1.0 candidate

Current limit: the site can compare existing evidence, but no candidate has yet been independently repeated in a DMD muscle model.

Research evidence only 21 observed HepG2 perturbations 0 independent DMD replications Boundary & release
Observed HepG2 perturbations with limited external myogenic context No validated DMD perturbation prediction v1.0.0-database-resource Frozen 25 Jul 2026 Schema 1.1 Model ridge-safe-v2.3 Benchmark repeated-fold-v2.2 Build EA-20260730-29 DOI pending Open evidence boundary →

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Independent disease-relevant outcomes are missing.

The current response substrate contains observed CRISPRi perturbations in HepG2, plus limited muscle-context and correction references. None is an independent candidate perturbation in a DMD muscle model.

  1. Observed same-context responses exist for 21 candidates.
  2. Only 9 candidates were represented in the external myoblast screen.
  3. No released candidate has an independent DMD muscle perturbation outcome.
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What this means: this is a transparent evidence navigator, not a general-purpose chatbot or clinical decision system.