Stable server-rendered gene record · v1.2.0-measured-dmd-evidence

CYP2E1

Inspect bounded evidence

G1 · DMD-background evidenceR0 · evidence annotation onlySupported · L1 resource recordAssessed · L1 resource record

What this meansCYP2E1 does not have an eligible observed perturbation in the current HepG2 release, but it has not been independently perturbed in a DMD muscle model. The available DMD source summaries should still be treated as contextual evidence rather than perturbation truth. The next useful step is an experiment that closes the current evidence gap—not a therapeutic claim.

通俗解释CYP2E1在当前HepG2数据中还没有合格的已观察扰动，但尚未在DMD肌肉模型中独立验证。现有DMD来源信息仍只是背景证据，不是扰动真值。下一步应完成能弥补当前证据缺口的受控实验，而不能把它直接称为治疗靶点。

Design the next experiment →

Prediction readinessR0 · evidence annotation only

Current evidenceVersioned resource record; no eligible HepG2 perturbation

Additional contextNo qualifying external myogenic screen

Historical DMD prior (legacy)down

Source agreement2/2 sources

Open core JSON Complete typed record

Gene Entity Page 2.1 · quantitative layer

Dataset-level evidence for CYP2E1

Every row keeps its original context, metric and denominator. Empty fields remain explicit; no cross-source meta-effect is computed.

Download evidence JSON →

IdentityReleasedHGNC:2631 · ENSG00000130649

PerturbationNot assessedNo qualifying cell aggregate

Muscle contextScreen not assessedExpression unavailable

DMD context2 source rowsContextual source summaries

DMD perturbation truthMissingNo independent DMD-muscle perturbation outcome

Calibrated predictionLockedR0 · no calibrated DMD response model

Dataset-level evidence rows for CYP2E1
Dataset / evidence	Context and endpoint	Observed value	Denominator / support	State and source
DMD single-cell baseline pseudobulkdisease context effect	Disease-associated baseline expressionDMD skeletal-muscle single-cell source; baseline pseudobulk summaries	-0.606981 source-specific effect scaleMedian signed score -0.00001032	2 contexts · 2 rows0 significant rows	context onlyOpen sourceObserved-expression source summary; contextual evidence rather than candidate perturbation truth.
DMD single-cell delta / DIDdisease context effect	Disease-associated change across declared contextsDMD skeletal-muscle single-cell source; final-label delta / DID summaries	-0.226254 source-specific effect scaleMedian signed score -0.00000957	2 contexts · 2 rows0 significant rows	context onlyOpen sourceObserved-expression source summary; contextual evidence rather than candidate perturbation truth.

Source-specific effect display

DMD source-effect forest

Position is scaled to the largest absolute effect shown for this gene. Values remain on source-specific scales and are not pooled.

sc baseline pseudobulk-0.6069812 contexts · 0/2 significant rows

sc delta/DID-0.2262542 contexts · 0/2 significant rows

independent dmd muscle perturbationmissing not negativeUnlock: Run an independent, quality-controlled perturbation in a declared DMD-relevant human myogenic model with biological replication.

per gene deg pathway and cell state profilenot published for this geneUnlock: Publish a per-gene inferential table with contrast, biological denominator, effect, uncertainty, multiplicity correction and provenance.

calibrated dmd response predictionlockedUnlock: Accumulate prospective DMD perturbation outcomes and pass the registered calibration, applicability and external-validation gates.

Dataset rows preserve their original context and scale. They are not pooled into a causal effect, therapeutic rank or calibrated DMD prediction.

Gene Entity Page 2.1

Entity graph: identity, evidence and prospective objects

This chain shows which objects exist for CYP2E1, which are still drafts and which registries are empty. Empty is not a negative experimental result.

v1.2.0-measured-dmd-evidence

Object IDGENE:v1.2.0-measured-dmd-evidence:CYP2E1

HGNCHGNC:2631

EnsemblENSG00000130649

NCBI Gene1571

Disease scopeDMD evidence context

01 · Gene objectRELEASEDStable identity and typed core record

02 · Evidence objectReleased record · no eligible perturbationNo DMD perturbation truth is implied

03 · Model gateR0 · R0 · evidence annotation onlyPredictionReadiness governance state

04 · Study objectNOT CREATEDNo candidate Study Card in this release

05 · Prediction objectEMPTYNo immutable prospective prediction

06 · Outcome objectEMPTYNo linked measured outcome

Core JSON Compare evidence Create a bounded study design Prediction registry

Claim boundary: object connectivity improves traceability; it does not raise the evidence tier or authorize a therapeutic claim.

Gene visual profile · 基因证据剖面

One-page evidence profile for CYP2E1

A four-panel, descriptive view of the same bounded gene record: evidence depth, DMD source matrix, context gauges and the current decision gap. No score, target rank or prediction claim is computed.

Evidence profile

L1 resourceStable record released
L2 HepG2 perturbationnot assessed
L3a external screenNot assessed
L3b independent replicationNot assessed
L4 DMD / muscle validationMissing
L5 therapeutic / clinicalUnsupported

DMD source matrix

sc baseline pseudobulkNegative source directionMedian effect -0.606981 · signed score -0.00001032observed expression · 2 contexts · 0/2 significant rows

sc delta/DIDNegative source directionMedian effect -0.226254 · signed score -0.00000957observed expression · 2 contexts · 0/2 significant rows

Observed-expression and regulatory-inference channels are displayed side by side and are not pooled as independent cohorts.

Context gauges

Source agreement2/2 sources

This measures agreement among source pipelines; it is not biological ground truth.

Muscle expressionNot available

Visual guide; ≥1 TPM is the current triage threshold.

Cells contributing to the aggregateNot available

Coverage count, not a power calculation.

External screenNot assessed

No qualifying evidence is available in this release; this is not a negative result.

Gap ladder

GAP-01Direct target-level perturbation evidence is absent

Current actionInspect bounded evidence
Highest missing layerL4 dmd functional validation
Claim boundaryNo P1/P2 prediction claim unlocked

Interpretation boundary: this visual profile reorganizes frozen fields for inspection. It does not create a source-balanced successor result, a causal conclusion, a therapeutic direction or a clinical decision-support claim.

Decision boundary

What must be resolved next

Decision-blocking gapGAP-01 · Direct target-level perturbation evidence is absent

Highest missing layerL4 dmd functional validation

Readiness upgrade requiredAdd a governed perturbation response or direct disease-relevant experimental evidence.

The decision-blocking gap is the next missing layer that prevents the current action from advancing. The highest missing layer is the longer-term evidence ceiling; it is not necessarily the next experiment.

DMD context

Source-state record

DMD source-state fields for CYP2E1
Direction state	consistent down
Variant stability	not assessed
Evidence modules	multisource direction consistent
Statistical support	direction only no significant context rows
Coverage	2 of 4 sources
Uncertainty	incomplete source coverage

Identifiers and context

Machine-resolvable core

Machine-resolvable identifiers and context for CYP2E1
HGNC	HGNC:2631
Ensembl	ENSG00000130649
NCBI Gene	1571
HepG2 perturbation	not assessed
HepG2 observed cells	Not available
Observed counteralignment	Not available
Myoblast screen	not assessed
Myoblast fusion-screen effect	Not available
Myoblast fusion-screen FDR	Not available
Skeletal-muscle expression	Not available
DepMap median gene effect	Not available

Cite this record

Stable identity

Object ID: GENE:v1.2.0-measured-dmd-evidence:CYP2E1

NMD-VCell. CYP2E1 evidence record. Resource v1.2.0-measured-dmd-evidence; evidence freeze 2026-08-03; schema 1.1; build EA-20260817-57. DOI pending.

Schema 1.1 · evidence freeze 2026-08-03 · build EA-20260817-57 · one of 17,921 stable core records.