Historical detailed audit

TLR4

Current authority:

Object IDGENE-AUDIT:v1.2.0-measured-dmd-evidence:TLR4

Current gene objectGENE:v1.2.0-measured-dmd-evidence:TLR4

Legacy integrated DMD priorup

Source conflict stateconflicted

DMD source audit

Observed expression and regulatory inference remain separate

Source	Evidence channel	Median effect	Contexts	Direction
dmd_single_cell_baseline_pseudobulk	observed expression	0.1257	14	Positive
dmd_single_cell_delta_did_final_labels	observed expression	-0.02142	14	Negative
sema3c_deseq2_source_state	observed expression	1.566	8	Positive
sema3c_formal_nichenet_target_state	regulatory inference	3.337	1	Positive

Dataset/cohort identifiers and sample-overlap flags are not yet encoded in this source object; no independence claim is made from these rows. Full numeric precision remains available in the JSON record.

Current boundary

What remains unresolved

GAP-01 · Direct target-level perturbation evidence is absent

The registered source-balanced successor will not treat regulatory inference as observed expression. It remains preregistered and uncomputed in this release.

Resource v1.2.0-measured-dmd-evidence · schema 1.1 · build EA-20260817-57