Evidence profile
- L1 resourceStable record released
- L2 HepG2 perturbationnot assessed
- L3a external screenNot assessed
- L3b independent replicationNot assessed
- L4 DMD / muscle validationMissing
- L5 therapeutic / clinicalUnsupported
Stable server-rendered gene record · v1.0.0-database-resource
CXCL11
Inspect bounded evidence
What this means: CXCL11 does not have an eligible observed perturbation in the current HepG2 release, but it has not been independently perturbed in a DMD muscle model. The available DMD source summaries should still be treated as contextual evidence rather than perturbation truth. The next useful step is an experiment that closes the current evidence gap—not a therapeutic claim.
通俗解释：CXCL11在当前HepG2数据中还没有合格的已观察扰动，但尚未在DMD肌肉模型中独立验证。现有DMD来源信息仍只是背景证据，不是扰动真值。下一步应完成能弥补当前证据缺口的受控实验，而不能把它直接称为治疗靶点。
Highest supportedL1 resource record
Highest assessedL1 resource record
Historical context · legacy integrated DMD priordown
Source agreement4/4 sources
Gene visual profile · 基因证据剖面
One-page evidence profile for CXCL11
A four-panel, descriptive view of the same bounded gene record: evidence depth, DMD source matrix, context gauges and the current decision gap. No score, target rank or prediction claim is computed.
DMD source matrix
sc baseline pseudobulkNegative source directionobserved expression · 4 contexts · 0 significant rows
sc delta/DIDNegative source directionobserved expression · 2 contexts · 0 significant rows
DESeq2 source-stateNegative source directionobserved expression · 5 contexts · 0 significant rows
NicheNet target-stateNegative source directionregulatory inference · 1 contexts · 0 significant rows
Observed-expression and regulatory-inference channels are displayed side by side and are not pooled as independent cohorts.
Context gauges
Source agreement4/4 sources
Audit agreement, not biological truth.Muscle expressionNot available
Visual guide; ≥1 TPM is the current triage threshold.Observed cellsNot available
Coverage count, not a power calculation.External screenNot assessed
Not assessed is missingness, not a negative result.Gap ladder
GAP-01Direct target-level perturbation evidence is absent
- Current actionInspect bounded evidence
- Highest missing layerL4 dmd functional validation
- Claim boundaryNo P1/P2 prediction claim unlocked
Interpretation boundary: this visual profile reorganizes frozen fields for inspection. It does not create a source-balanced successor result, a causal conclusion, a therapeutic direction or a clinical decision-support claim.
Decision boundary
What must be resolved next
Decision-blocking gapGAP-01 · Direct target-level perturbation evidence is absent
Highest missing layerL4 dmd functional validation
The decision-blocking gap is the next missing layer that prevents the current action from advancing. The highest missing layer is the longer-term evidence ceiling; it is not necessarily the next experiment.
DMD context
Source-state record
| Direction state | consistent down |
|---|---|
| Variant stability | not assessed |
| Evidence modules | exploratory multisource core |
| Statistical support | direction only no significant context rows |
| Coverage | 4 of 4 sources |
| Uncertainty | direction consistent not formal meta analysis |
Identifiers and context
Machine-resolvable core
| HGNC | HGNC:10638 |
|---|---|
| Ensembl | ENSG00000169248 |
| NCBI Gene | 6373 |
| HepG2 perturbation | not assessed |
| Myoblast screen | not assessed |
| Skeletal-muscle expression | Not available |
Cite this record
Stable identity
Object ID: GENE:v1.0.0-database-resource:CXCL11
NMD-VCell Research Workbench. CXCL11 evidence record. Resource v1.0.0-database-resource; evidence freeze 2026-07-25; schema 1.1; build EA-20260729-20. DOI pending.