Stable server-rendered gene record · v1.2.0-measured-dmd-evidence
BET1
Inspect bounded evidence
G4 · muscle-context screen, not DMD replicationR0 · evidence annotation onlySupported · L1 resource recordAssessed · L3a external context screen
What this meansBET1 does not have an eligible observed perturbation in the current HepG2 release, but it has not been independently perturbed in a DMD muscle model. Different DMD datasets do not completely agree on its disease-associated direction. The next useful step is an experiment that closes the current evidence gap—not a therapeutic claim.
通俗解释BET1在当前HepG2数据中还没有合格的已观察扰动，但尚未在DMD肌肉模型中独立验证。不同DMD数据集对它的疾病相关方向并不完全一致。下一步应完成能弥补当前证据缺口的受控实验，而不能把它直接称为治疗靶点。
Design the next experiment →Prediction readinessR0 · evidence annotation only
Current evidenceVersioned resource record; no eligible HepG2 perturbation
Additional contextAssessed · no current hit
Historical DMD prior (legacy)up
Source agreement2/4 sources
Gene Entity Page 2.1 · quantitative layer
Dataset-level evidence for BET1
Every row keeps its original context, metric and denominator. Empty fields remain explicit; no cross-source meta-effect is computed.
| Dataset / evidence | Context and endpoint | Observed value | Denominator / support | State and source |
|---|---|---|---|---|
| GSE293514screen result | Fusion-positive enrichmentHealthy human myoblast fusion CRISPR screen | 0.13164 log fold-changeFDR 0.999999 | 1 contexts · 1 rows0 significant rows | assessed no hitOpen sourceHealthy-myoblast fusion endpoint only. A no-hit result is endpoint-specific and is not evidence of no muscle or DMD effect. |
| DMD single-cell baseline pseudobulkdisease context effect | Disease-associated baseline expressionDMD skeletal-muscle single-cell source; baseline pseudobulk summaries | 0.405846 source-specific effect scaleMedian signed score 0.00001848 | 19 contexts · 19 rows0 significant rows | context onlyOpen sourceObserved-expression source summary; contextual evidence rather than candidate perturbation truth. |
| DMD single-cell delta / DIDdisease context effect | Disease-associated change across declared contextsDMD skeletal-muscle single-cell source; final-label delta / DID summaries | -0.141855 source-specific effect scaleMedian signed score -0.00000437 | 20 contexts · 20 rows0 significant rows | context onlyOpen sourceObserved-expression source summary; contextual evidence rather than candidate perturbation truth. |
| SEMA3C DESeq2 source-statedisease context effect | Source-specific differential expressionDMD skeletal-muscle source-state analysis | -0.124385 source-specific effect scaleMedian signed score -0.00001943 | 9 contexts · 9 rows0 significant rows | context onlyOpen sourceObserved-expression source summary; contextual evidence rather than candidate perturbation truth. |
| SEMA3C NicheNet target-statedisease context effect | Inferred target-state relationshipDMD skeletal-muscle regulatory-inference context | 0.535134 source-specific effect scaleMedian signed score 0.03225276 | 2 contexts · 2 rows0 significant rows | context onlyOpen sourceRegulatory-inference channel; displayed separately and not pooled as an independent expression cohort. |
Source-specific effect display
DMD source-effect forest
Position is scaled to the largest absolute effect shown for this gene. Values remain on source-specific scales and are not pooled.
sc baseline pseudobulk+0.40584619 contexts · 0/19 significant rows
sc delta/DID-0.14185520 contexts · 0/20 significant rows
DESeq2 source-state-0.1243859 contexts · 0/9 significant rows
NicheNet target-state+0.5351342 contexts · 0/2 significant rows
Dataset rows preserve their original context and scale. They are not pooled into a causal effect, therapeutic rank or calibrated DMD prediction.
Gene Entity Page 2.1
Entity graph: identity, evidence and prospective objects
This chain shows which objects exist for BET1, which are still drafts and which registries are empty. Empty is not a negative experimental result.
Object ID
GENE:v1.2.0-measured-dmd-evidence:BET1HGNCHGNC:14562
EnsemblENSG00000105829
NCBI Gene10282
Disease scopeDMD evidence context
01 · Gene objectRELEASEDStable identity and typed core record
→02 · Evidence objectReleased record · no eligible perturbationNo DMD perturbation truth is implied
→03 · Model gateR0 · R0 · evidence annotation onlyPredictionReadiness governance state
→04 · Study objectNOT CREATEDNo candidate Study Card in this release
→05 · Prediction objectEMPTYNo immutable prospective prediction
→06 · Outcome objectEMPTYNo linked measured outcome
Claim boundary: object connectivity improves traceability; it does not raise the evidence tier or authorize a therapeutic claim.
Gene visual profile · 基因证据剖面
One-page evidence profile for BET1
A four-panel, descriptive view of the same bounded gene record: evidence depth, DMD source matrix, context gauges and the current decision gap. No score, target rank or prediction claim is computed.
Evidence profile
- L1 resourceStable record released
- L2 HepG2 perturbationnot assessed
- L3a external screenAssessed · no current hit
- L3b independent replicationNot assessed
- L4 DMD / muscle validationMissing
- L5 therapeutic / clinicalUnsupported
DMD source matrix
sc baseline pseudobulkPositive source directionMedian effect +0.405846 · signed score 0.00001848observed expression · 19 contexts · 0/19 significant rows
sc delta/DIDNegative source directionMedian effect -0.141855 · signed score -0.00000437observed expression · 20 contexts · 0/20 significant rows
DESeq2 source-stateNegative source directionMedian effect -0.124385 · signed score -0.00001943observed expression · 9 contexts · 0/9 significant rows
NicheNet target-statePositive source directionMedian effect +0.535134 · signed score 0.03225276regulatory inference · 2 contexts · 0/2 significant rows
Observed-expression and regulatory-inference channels are displayed side by side and are not pooled as independent cohorts.
Context gauges
Source agreement2/4 sources
This measures agreement among source pipelines; it is not biological ground truth.Muscle expressionNot available
Visual guide; ≥1 TPM is the current triage threshold.Cells contributing to the aggregateNot available
Coverage count, not a power calculation.External screenAssessed · no current hit
This no-hit result is specific to the fusion-screen endpoint; it does not show that the gene has no muscle function.Gap ladder
GAP-01Direct target-level perturbation evidence is absent
- Current actionInspect bounded evidence
- Highest missing layerL4 dmd functional validation
- Claim boundaryNo P1/P2 prediction claim unlocked
Interpretation boundary: this visual profile reorganizes frozen fields for inspection. It does not create a source-balanced successor result, a causal conclusion, a therapeutic direction or a clinical decision-support claim.
Decision boundary
What must be resolved next
Decision-blocking gapGAP-01 · Direct target-level perturbation evidence is absent
Highest missing layerL4 dmd functional validation
Readiness upgrade requiredAdd a governed perturbation response or direct disease-relevant experimental evidence.
The decision-blocking gap is the next missing layer that prevents the current action from advancing. The highest missing layer is the longer-term evidence ceiling; it is not necessarily the next experiment.
DMD context
Source-state record
| Direction state | conflicted |
|---|---|
| Variant stability | not assessed |
| Evidence modules | direction conflicted |
| Statistical support | direction only no significant context rows |
| Coverage | 4 of 4 sources |
| Uncertainty | direction conflict retained |
Identifiers and context
Machine-resolvable core
| HGNC | HGNC:14562 |
|---|---|
| Ensembl | ENSG00000105829 |
| NCBI Gene | 10282 |
| HepG2 perturbation | not assessed |
| HepG2 observed cells | Not available |
| Observed counteralignment | Not available |
| Myoblast screen | assessed |
| Myoblast fusion-screen effect | 0.13164 log fold-change |
| Myoblast fusion-screen FDR | 0.999999 |
| Skeletal-muscle expression | Not available |
| DepMap median gene effect | Not available |
Cite this record
Stable identity
Object ID: GENE:v1.2.0-measured-dmd-evidence:BET1
NMD-VCell. BET1 evidence record. Resource v1.2.0-measured-dmd-evidence; evidence freeze 2026-08-03; schema 1.1; build EA-20260817-57. DOI pending.