NMD-VCell Evidence & Experiment Workbench Audit DMD evidence, compare gaps, and freeze the missing test Module: Compare · evidence-to-experiment workflow NMD = neuromuscular disorders
Search Data & API Current release

Current limit: the site can compare existing evidence, but no candidate has yet been independently repeated in a DMD muscle model.

Research evidence only 21 prioritized candidate perturbation records 2,160 benchmark perturbation targets 250 observed human-myoblast fusion hits Prospective DMD candidate validation pending Boundary & release
21 Workbench candidates are surfaced for consideration, not ranked as validated targets 2,160 target-level perturbation responses form the frozen HepG2 benchmark substrate GSE293514 Stage B0 contributes 250 healthy-human-myoblast fusion hits and 125 individually validated genes No validated DMD perturbation prediction v1.2.0-measured-dmd-evidence Frozen 3 August 2026 Schema 1.1 Model ridge-safe-v2.3 Benchmark repeated-fold-v2.2 Build EA-20260804-49 DOI pending Open evidence boundary →

Mixed action and gap comparison · CMP-20260726-BF1FA85ADE20

Released comparison object · v1.2.0-measured-dmd-evidence

Mixed action and gap comparison

4 mapped genes · immutable · no ranking generated

Object IDCMP-20260726-BF1FA85ADE20
LifecycleRELEASED
Gene schema1.1
Object creation buildEA-20260730-42
Current interface buildEA-20260804-49
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Preserved evidence dimensions

Input order preserved; actions and gaps are not collapsed into a composite score
GeneCurrent actionHighest supportedLegacy integrated DMD priorSource agreementDecision-blocking gap
ZNF133 Muscle-context assay L2 observed same context perturbation up 3/4 GAP-02 Independent muscle-context perturbation is absent
WDR4 Risk/context review L2 observed same context perturbation up 4/4 GAP-08 Safety and dependency context blocks escalation
GFOD2 Provisional hold · external report not yet audited L2 observed same context perturbation up 2/4 GAP-09 External quantitative evidence has not been imported and audited
INTS13 Risk/context review L2 observed same context perturbation up 4/4 GAP-08 Safety and dependency context blocks escalation
Build identity. The object creation build records when the checksum-addressed payload was frozen. The current interface build only renders it and does not rewrite the payload, values or SHA-256.
Claim boundary. This comparison preserves evidence dimensions and missingness. It does not create a composite score, ranking, causal claim or therapeutic recommendation.
Cite this comparison

Object ID: CMP-20260726-BF1FA85ADE20

Payload SHA-256: bf1fa85ade20ed7a5799e64265df78b3b50175018c1dd08764df68b3a3b3935a. Stable URL: https://nmdvcell.com/resource/comparison/CMP-20260726-BF1FA85ADE20/.