NMD-VCell Disease Virtual Cell Platform Specify a cell-state question, inspect computability, and design the missing test Module: Compare · evidence-to-experiment workflow NMD = neuromuscular disorders

Current limit: the site can compare existing evidence, but no candidate has yet been independently repeated in a DMD muscle model.

Research evidence only 21 observed HepG2 perturbations 0 independent DMD replications Boundary & release
Observed HepG2 perturbations with limited external myogenic context No validated DMD perturbation prediction v1.0.0-database-resource Frozen 25 Jul 2026 Schema 1.1 Model ridge-safe-v2.3 Benchmark repeated-fold-v2.2 Build EA-20260730-42 DOI pending Open evidence boundary →

Computational-replication queue

Released comparison object · v1.0.0-database-resource

Computational-replication queue

3 mapped genes · immutable · no ranking generated

Object IDCMP-20260726-E81245A1B506
LifecycleRELEASED
Gene schema1.1
Object creation buildEA-20260730-42
Current interface buildEA-20260730-42

Preserved evidence dimensions

Input order preserved; actions and gaps are not collapsed into a composite score
GeneCurrent actionHighest supportedLegacy integrated DMD priorSource agreementDecision-blocking gap
INTS13 Risk/context review L2 observed same context perturbation up 4/4 GAP-08 Safety and dependency context blocks escalation
NAGLU Risk/context review L2 observed same context perturbation up 3/4 GAP-08 Safety and dependency context blocks escalation
RNF8 Risk/context review L2 observed same context perturbation up 2/4 GAP-08 Safety and dependency context blocks escalation
Build identity. The object creation build records when the checksum-addressed payload was frozen. The current interface build only renders it and does not rewrite the payload, values or SHA-256.
Claim boundary. This comparison preserves evidence dimensions and missingness. It does not create a composite score, ranking, causal claim or therapeutic recommendation.
Cite this comparison

Object ID: CMP-20260726-E81245A1B506

Payload SHA-256: e81245a1b50609e8accf1ec6a2f0e2fe61b8c405326b13e529e6c02fc019c628. Stable URL: https://nmdvcell.com/resource/comparison/CMP-20260726-E81245A1B506/.