NMD-VCell Evidence & Experiment Workbench Audit DMD evidence, compare gaps, and freeze the missing test Module: Compare · evidence-to-experiment workflow NMD = neuromuscular disorders

Current limit: the site can compare existing evidence, but no candidate has yet been independently repeated in a DMD muscle model.

Research evidence only 21 prioritized candidate perturbation records 2,160 benchmark perturbation targets 250 observed human-myoblast fusion hits Prospective DMD candidate validation pending Boundary & release
21 Workbench candidates are surfaced for consideration, not ranked as validated targets 2,160 target-level perturbation responses form the frozen HepG2 benchmark substrate GSE293514 Stage B0 contributes 250 healthy-human-myoblast fusion hits and 125 individually validated genes No validated DMD perturbation prediction v1.2.0-measured-dmd-evidence Frozen 3 August 2026 Schema 1.1 Model ridge-safe-v2.3 Benchmark repeated-fold-v2.2 Build EA-20260804-49 DOI pending Open evidence boundary →

Shared-action comparison · CMP-20260726-311ECF4EC825

Released comparison object · v1.2.0-measured-dmd-evidence

Shared-action comparison

2 mapped genes · immutable · no ranking generated

Object IDCMP-20260726-311ECF4EC825
LifecycleRELEASED
Gene schema1.1
Object creation buildEA-20260730-42
Current interface buildEA-20260804-49

Preserved evidence dimensions

Input order preserved; actions and gaps are not collapsed into a composite score
GeneCurrent actionHighest supportedLegacy integrated DMD priorSource agreementDecision-blocking gap
ZNF133 Muscle-context assay L2 observed same context perturbation up 3/4 GAP-02 Independent muscle-context perturbation is absent
MON1A Muscle-context assay L2 observed same context perturbation up 2/4 GAP-02 Independent muscle-context perturbation is absent
Build identity. The object creation build records when the checksum-addressed payload was frozen. The current interface build only renders it and does not rewrite the payload, values or SHA-256.
Claim boundary. This comparison preserves evidence dimensions and missingness. It does not create a composite score, ranking, causal claim or therapeutic recommendation.
Cite this comparison

Object ID: CMP-20260726-311ECF4EC825

Payload SHA-256: 311ecf4ec82557071e43cb235338ba488e47ba3f266ace7438a480095c926269. Stable URL: https://nmdvcell.com/resource/comparison/CMP-20260726-311ECF4EC825/.