gene section dataset_or_field context metric value unit denominator status interpretation source_url ZNF133 dataset_evidence HEPG2_CRISPRI_FROZEN_AGGREGATE HepG2; CRISPRi; non-muscle, non-DMD context observed_cells 84 cells 84 cells measured Observed perturbation coverage in HepG2. The cells are not independent biological replicates and do not establish a DMD effect. /resource/perturbation/ZNF133/ ZNF133 dataset_evidence GTEX_V8_SKELETAL_MUSCLE Human skeletal muscle tissue median_tpm 4.55781 TPM 1 contexts; row count unavailable context_only Tissue expression supports assay feasibility only; it does not establish cell-type expression, function or perturbation response. /resource/api/v1.1/core-gene/ZNF133 ZNF133 dataset_evidence DEPMAP_CONTEXT_METRIC DepMap cell-line dependency context; not muscle-specific median_gene_effect -0.0375505223925062 DepMap gene-effect score context_only A broad dependency context metric. It is not a safety result and is not evidence of disease-selective dependency. /resource/api/v1.1/core-gene/ZNF133 ZNF133 dataset_evidence HEPG2_CONTEXT_RELATIONSHIP_V06 Same processed HepG2 perturbation substrate observed_counteralignment 0.0638177433316608 unitless score 84 cells contributing to the target aggregate context_only A descriptive relationship within the same processed context; it is not therapeutic rescue or an independently validated effect. /resource/perturbation/ZNF133/ ZNF133 dataset_evidence GSE293514 Healthy human myoblast fusion CRISPR screen fusion_positive_log_fold_change -0.003533 log fold-change 1 contexts; 1 rows assessed_no_hit Healthy-myoblast fusion endpoint only. A no-hit result is endpoint-specific and is not evidence of no muscle or DMD effect. https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE293514 ZNF133 dataset_evidence DMD single-cell baseline pseudobulk DMD skeletal-muscle single-cell source; baseline pseudobulk summaries median_source_effect 0.11902841214913759 source-specific effect scale 18 contexts; 18 rows context_only Observed-expression source summary; contextual evidence rather than candidate perturbation truth. /resource/api/v1.2/dmd-prior/genes/ZNF133.json ZNF133 dataset_evidence DMD single-cell delta / DID DMD skeletal-muscle single-cell source; final-label delta / DID summaries median_source_effect -0.4262708624811017 source-specific effect scale 19 contexts; 19 rows context_only Observed-expression source summary; contextual evidence rather than candidate perturbation truth. /resource/api/v1.2/dmd-prior/genes/ZNF133.json ZNF133 dataset_evidence SEMA3C DESeq2 source-state DMD skeletal-muscle source-state analysis median_source_effect 0.0709138483319497 source-specific effect scale 9 contexts; 9 rows context_only Observed-expression source summary; contextual evidence rather than candidate perturbation truth. /resource/api/v1.2/dmd-prior/genes/ZNF133.json ZNF133 dataset_evidence SEMA3C NicheNet target-state DMD skeletal-muscle regulatory-inference context median_source_effect 0.3738200422540365 source-specific effect scale 1 contexts; 1 rows context_only Regulatory-inference channel; displayed separately and not pooled as an independent expression cohort. /resource/api/v1.2/dmd-prior/genes/ZNF133.json ZNF133 measured_source_context HEPG2_CANDIDATE_CELLS HepG2 source response and cross-context DMD pathway projection candidate_cells 84 cells 4976 control cells cell_level_exploratory Cell coverage without a biological-replicate column; not donor-level or disease-level inference. /resource/api/v1.7/candidate-dmd-statistical-bridge/candidate-summary.json ZNF133 measured_source_context TARGET_GENE_DELTA HepG2 source response and cross-context DMD pathway projection target_gene_delta normalized expression delta target-gene coordinate not_measured Target-gene delta is missing, not zero. /resource/api/v1.7/candidate-dmd-statistical-bridge/candidate-summary.json ZNF133 measured_source_context CELL_LEVEL_DE HepG2 source response and cross-context DMD pathway projection fdr_lt_0_05_abs_delta_ge_0_1 2 rows 26 rows at cell-level FDR < 0.05 cell_level_exploratory No biological-replicate column; donor-level and disease-level inference are blocked. /resource/api/v1.7/candidate-dmd-statistical-bridge/candidate-summary.json ZNF133 measured_source_context REACTOME_CAMERA HepG2 source response and cross-context DMD pathway projection robust_camera_pathways 0 pathways 1378 tested; 0 up; 0 down source_context_only Competitive pathway tests in the source context do not establish a candidate response in DMD muscle. /resource/api/v1.7/candidate-dmd-statistical-bridge/candidate-summary.json ZNF133 cross_context_dmd_projection GSE233606 separately measured DMD pathway axis direct_projection_spearman -0.021200784790329618 rho 1360 pathways exploratory_context_only Not a measured candidate response in DMD muscle; source vectors are not independent studies. https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE233606 ZNF133 cross_context_dmd_projection GSE233606 separately measured DMD pathway axis cascade_projection_spearman -0.007994165540419642 rho 1360 pathways exploratory_context_only Not a measured candidate response in DMD muscle; source vectors are not independent studies. https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE233606 ZNF133 cross_context_dmd_projection GSE272233 separately measured DMD pathway axis direct_projection_spearman -0.047498709207570135 rho 1320 pathways exploratory_context_only Not a measured candidate response in DMD muscle; source vectors are not independent studies. https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE272233 ZNF133 cross_context_dmd_projection GSE272233 separately measured DMD pathway axis cascade_projection_spearman -0.07517585258758422 rho 1320 pathways exploratory_context_only Not a measured candidate response in DMD muscle; source vectors are not independent studies. https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE272233 ZNF133 cross_context_dmd_projection GSE277637 separately measured DMD pathway axis direct_projection_spearman -0.04624065142645514 rho 1360 pathways exploratory_context_only Not a measured candidate response in DMD muscle; source vectors are not independent studies. https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE277637 ZNF133 cross_context_dmd_projection GSE277637 separately measured DMD pathway axis cascade_projection_spearman -0.1318108233204808 rho 1360 pathways exploratory_context_only Not a measured candidate response in DMD muscle; source vectors are not independent studies. https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE277637 ZNF133 heterogeneity_and_alignment CROSS_SOURCE_SUMMARY HepG2 source response and cross-context DMD pathway projection pooled_rescue_spearman -0.03822746261761357 rho overlapping pathways and non-independent source vectors exploratory_descriptive_summary The pooled value is descriptive and does not establish validation, rescue, efficacy, or rank. /resource/api/v1.7/candidate-dmd-statistical-bridge/candidate-summary.json ZNF133 heterogeneity_and_alignment CROSS_SOURCE_SUMMARY HepG2 source response and cross-context DMD pathway projection cochran_q 0.5951896176227366 Q overlapping pathways and non-independent source vectors exploratory_descriptive_summary The pooled value is descriptive and does not establish validation, rescue, efficacy, or rank. /resource/api/v1.7/candidate-dmd-statistical-bridge/candidate-summary.json ZNF133 heterogeneity_and_alignment CROSS_SOURCE_SUMMARY HepG2 source response and cross-context DMD pathway projection i2_percent 0 percent overlapping pathways and non-independent source vectors exploratory_descriptive_summary The pooled value is descriptive and does not establish validation, rescue, efficacy, or rank. /resource/api/v1.7/candidate-dmd-statistical-bridge/candidate-summary.json ZNF133 heterogeneity_and_alignment CROSS_SOURCE_SUMMARY HepG2 source response and cross-context DMD pathway projection source_direction_consistent true boolean overlapping pathways and non-independent source vectors exploratory_descriptive_summary The pooled value is descriptive and does not establish validation, rescue, efficacy, or rank. /resource/api/v1.7/candidate-dmd-statistical-bridge/candidate-summary.json ZNF133 heterogeneity_and_alignment CROSS_SOURCE_SUMMARY HepG2 source response and cross-context DMD pathway projection correction_alignment_spearman -0.15228301712959624 rho overlapping pathways and non-independent source vectors exploratory_descriptive_summary The pooled value is descriptive and does not establish validation, rescue, efficacy, or rank. /resource/api/v1.7/candidate-dmd-statistical-bridge/candidate-summary.json ZNF133 heterogeneity_and_alignment CROSS_SOURCE_SUMMARY HepG2 source response and cross-context DMD pathway projection cascade_pooled_rescue_spearman -0.0718077656457758 rho overlapping pathways and non-independent source vectors exploratory_descriptive_summary The pooled value is descriptive and does not establish validation, rescue, efficacy, or rank. /resource/api/v1.7/candidate-dmd-statistical-bridge/candidate-summary.json ZNF133 heterogeneity_and_alignment CROSS_SOURCE_SUMMARY HepG2 source response and cross-context DMD pathway projection cascade_cochran_q 10.55420850954244 Q overlapping pathways and non-independent source vectors exploratory_descriptive_summary The pooled value is descriptive and does not establish validation, rescue, efficacy, or rank. /resource/api/v1.7/candidate-dmd-statistical-bridge/candidate-summary.json ZNF133 heterogeneity_and_alignment CROSS_SOURCE_SUMMARY HepG2 source response and cross-context DMD pathway projection cascade_i2_percent 81.05021330408881 percent overlapping pathways and non-independent source vectors exploratory_descriptive_summary The pooled value is descriptive and does not establish validation, rescue, efficacy, or rank. /resource/api/v1.7/candidate-dmd-statistical-bridge/candidate-summary.json ZNF133 heterogeneity_and_alignment CROSS_SOURCE_SUMMARY HepG2 source response and cross-context DMD pathway projection cascade_source_direction_consistent true boolean overlapping pathways and non-independent source vectors exploratory_descriptive_summary The pooled value is descriptive and does not establish validation, rescue, efficacy, or rank. /resource/api/v1.7/candidate-dmd-statistical-bridge/candidate-summary.json ZNF133 heterogeneity_and_alignment CROSS_SOURCE_SUMMARY HepG2 source response and cross-context DMD pathway projection cascade_correction_alignment_spearman -0.10483291891757043 rho overlapping pathways and non-independent source vectors exploratory_descriptive_summary The pooled value is descriptive and does not establish validation, rescue, efficacy, or rank. /resource/api/v1.7/candidate-dmd-statistical-bridge/candidate-summary.json ZNF133 governance_boundary BRIDGE_PROJECTION_STATE HepG2 source response and cross-context DMD pathway projection decision_state ABSTAIN_OR_VALIDATE_IN_DMD_PERTURB_SEQ state one governed candidate L2_CROSS_CONTEXT_NETWORK_HYPOTHESIS_ONLY Bridge projection state only; it does not override the governed current action or create a rank. /resource/api/v1.7/candidate-dmd-statistical-bridge/candidate-summary.json ZNF133 governance_boundary ABSTENTION_REASONS HepG2 source response and cross-context DMD pathway projection abstention_reasons weak_split_half_measurement;disease_source_projection_inconsistent;correction_alignment_not_positive;target_engagement_coordinate_missing_or_not_suppressed semicolon-delimited reasons one governed candidate recorded A missing additional reason does not unlock validation; disease-matched candidate evidence is still required. /resource/api/v1.7/candidate-dmd-statistical-bridge/candidate-summary.json ZNF133 governance_boundary DMD_CANDIDATE_TRUTH HepG2 source response and cross-context DMD pathway projection measured_dmd_candidate_truth 0/21 candidate outcomes 21 governed candidates locked Cross-context projection is not measured candidate response in DMD muscle. /resource/api/v1.7/candidate-dmd-statistical-bridge/candidate-summary.json ZNF133 governance_boundary VALIDATED_PREDICTIONS HepG2 source response and cross-context DMD pathway projection validated_candidate_level_dmd_pathway_predictions 0 predictions 21 governed candidates locked No candidate-level DMD pathway prediction has been validated. /resource/api/v1.7/candidate-dmd-statistical-bridge/candidate-summary.json