gene section dataset_or_field context metric value unit denominator status interpretation source_url ZFP69B dataset_evidence HEPG2_CRISPRI_FROZEN_AGGREGATE HepG2; CRISPRi; non-muscle, non-DMD context observed_cells 81 cells 81 cells measured Observed perturbation coverage in HepG2. The cells are not independent biological replicates and do not establish a DMD effect. /resource/perturbation/ZFP69B/ ZFP69B dataset_evidence GTEX_V8_SKELETAL_MUSCLE Human skeletal muscle tissue median_tpm 0.155208 TPM 1 contexts; row count unavailable context_only Tissue expression supports assay feasibility only; it does not establish cell-type expression, function or perturbation response. /resource/api/v1.1/core-gene/ZFP69B ZFP69B dataset_evidence DEPMAP_CONTEXT_METRIC DepMap cell-line dependency context; not muscle-specific median_gene_effect -0.1074611086158024 DepMap gene-effect score context_only A broad dependency context metric. It is not a safety result and is not evidence of disease-selective dependency. /resource/api/v1.1/core-gene/ZFP69B ZFP69B dataset_evidence HEPG2_CONTEXT_RELATIONSHIP_V06 Same processed HepG2 perturbation substrate observed_counteralignment 0.0563412545485794 unitless score 81 cells contributing to the target aggregate context_only A descriptive relationship within the same processed context; it is not therapeutic rescue or an independently validated effect. /resource/perturbation/ZFP69B/ ZFP69B dataset_evidence DMD single-cell baseline pseudobulk DMD skeletal-muscle single-cell source; baseline pseudobulk summaries median_source_effect 0.4049400002864964 source-specific effect scale 3 contexts; 3 rows context_only Observed-expression source summary; contextual evidence rather than candidate perturbation truth. /resource/api/v1.2/dmd-prior/genes/ZFP69B.json ZFP69B dataset_evidence DMD single-cell delta / DID DMD skeletal-muscle single-cell source; final-label delta / DID summaries median_source_effect 0.025140599167349002 source-specific effect scale 4 contexts; 4 rows context_only Observed-expression source summary; contextual evidence rather than candidate perturbation truth. /resource/api/v1.2/dmd-prior/genes/ZFP69B.json ZFP69B dataset_evidence SEMA3C DESeq2 source-state DMD skeletal-muscle source-state analysis median_source_effect -0.1071941544445301 source-specific effect scale 4 contexts; 4 rows context_only Observed-expression source summary; contextual evidence rather than candidate perturbation truth. /resource/api/v1.2/dmd-prior/genes/ZFP69B.json ZFP69B measured_source_context HEPG2_CANDIDATE_CELLS HepG2 source response and cross-context DMD pathway projection candidate_cells 81 cells 4976 control cells cell_level_exploratory Cell coverage without a biological-replicate column; not donor-level or disease-level inference. /resource/api/v1.7/candidate-dmd-statistical-bridge/candidate-summary.json ZFP69B measured_source_context TARGET_GENE_DELTA HepG2 source response and cross-context DMD pathway projection target_gene_delta normalized expression delta target-gene coordinate not_measured Target-gene delta is missing, not zero. /resource/api/v1.7/candidate-dmd-statistical-bridge/candidate-summary.json ZFP69B measured_source_context CELL_LEVEL_DE HepG2 source response and cross-context DMD pathway projection fdr_lt_0_05_abs_delta_ge_0_1 1 rows 10 rows at cell-level FDR < 0.05 cell_level_exploratory No biological-replicate column; donor-level and disease-level inference are blocked. /resource/api/v1.7/candidate-dmd-statistical-bridge/candidate-summary.json ZFP69B measured_source_context REACTOME_CAMERA HepG2 source response and cross-context DMD pathway projection robust_camera_pathways 0 pathways 1378 tested; 0 up; 0 down source_context_only Competitive pathway tests in the source context do not establish a candidate response in DMD muscle. /resource/api/v1.7/candidate-dmd-statistical-bridge/candidate-summary.json ZFP69B cross_context_dmd_projection GSE233606 separately measured DMD pathway axis direct_projection_spearman 0.015276986604846993 rho 1360 pathways exploratory_context_only Not a measured candidate response in DMD muscle; source vectors are not independent studies. https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE233606 ZFP69B cross_context_dmd_projection GSE233606 separately measured DMD pathway axis cascade_projection_spearman -0.01328340336322973 rho 1360 pathways exploratory_context_only Not a measured candidate response in DMD muscle; source vectors are not independent studies. https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE233606 ZFP69B cross_context_dmd_projection GSE272233 separately measured DMD pathway axis direct_projection_spearman 0.06309087731627631 rho 1320 pathways exploratory_context_only Not a measured candidate response in DMD muscle; source vectors are not independent studies. https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE272233 ZFP69B cross_context_dmd_projection GSE272233 separately measured DMD pathway axis cascade_projection_spearman 0.19695019976099384 rho 1320 pathways exploratory_context_only Not a measured candidate response in DMD muscle; source vectors are not independent studies. https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE272233 ZFP69B cross_context_dmd_projection GSE277637 separately measured DMD pathway axis direct_projection_spearman 0.22949455974215227 rho 1360 pathways exploratory_context_only Not a measured candidate response in DMD muscle; source vectors are not independent studies. https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE277637 ZFP69B cross_context_dmd_projection GSE277637 separately measured DMD pathway axis cascade_projection_spearman 0.13915131906557054 rho 1360 pathways exploratory_context_only Not a measured candidate response in DMD muscle; source vectors are not independent studies. https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE277637 ZFP69B heterogeneity_and_alignment CROSS_SOURCE_SUMMARY HepG2 source response and cross-context DMD pathway projection pooled_rescue_spearman 0.10406364386111017 rho overlapping pathways and non-independent source vectors exploratory_descriptive_summary The pooled value is descriptive and does not establish validation, rescue, efficacy, or rank. /resource/api/v1.7/candidate-dmd-statistical-bridge/candidate-summary.json ZFP69B heterogeneity_and_alignment CROSS_SOURCE_SUMMARY HepG2 source response and cross-context DMD pathway projection cochran_q 35.68800594744478 Q overlapping pathways and non-independent source vectors exploratory_descriptive_summary The pooled value is descriptive and does not establish validation, rescue, efficacy, or rank. /resource/api/v1.7/candidate-dmd-statistical-bridge/candidate-summary.json ZFP69B heterogeneity_and_alignment CROSS_SOURCE_SUMMARY HepG2 source response and cross-context DMD pathway projection i2_percent 94.39587629820153 percent overlapping pathways and non-independent source vectors exploratory_descriptive_summary The pooled value is descriptive and does not establish validation, rescue, efficacy, or rank. /resource/api/v1.7/candidate-dmd-statistical-bridge/candidate-summary.json ZFP69B heterogeneity_and_alignment CROSS_SOURCE_SUMMARY HepG2 source response and cross-context DMD pathway projection source_direction_consistent true boolean overlapping pathways and non-independent source vectors exploratory_descriptive_summary The pooled value is descriptive and does not establish validation, rescue, efficacy, or rank. /resource/api/v1.7/candidate-dmd-statistical-bridge/candidate-summary.json ZFP69B heterogeneity_and_alignment CROSS_SOURCE_SUMMARY HepG2 source response and cross-context DMD pathway projection correction_alignment_spearman -0.14494139693388536 rho overlapping pathways and non-independent source vectors exploratory_descriptive_summary The pooled value is descriptive and does not establish validation, rescue, efficacy, or rank. /resource/api/v1.7/candidate-dmd-statistical-bridge/candidate-summary.json ZFP69B heterogeneity_and_alignment CROSS_SOURCE_SUMMARY HepG2 source response and cross-context DMD pathway projection cascade_pooled_rescue_spearman 0.10746049507282801 rho overlapping pathways and non-independent source vectors exploratory_descriptive_summary The pooled value is descriptive and does not establish validation, rescue, efficacy, or rank. /resource/api/v1.7/candidate-dmd-statistical-bridge/candidate-summary.json ZFP69B heterogeneity_and_alignment CROSS_SOURCE_SUMMARY HepG2 source response and cross-context DMD pathway projection cascade_cochran_q 32.39615728061815 Q overlapping pathways and non-independent source vectors exploratory_descriptive_summary The pooled value is descriptive and does not establish validation, rescue, efficacy, or rank. /resource/api/v1.7/candidate-dmd-statistical-bridge/candidate-summary.json ZFP69B heterogeneity_and_alignment CROSS_SOURCE_SUMMARY HepG2 source response and cross-context DMD pathway projection cascade_i2_percent 93.82642829309712 percent overlapping pathways and non-independent source vectors exploratory_descriptive_summary The pooled value is descriptive and does not establish validation, rescue, efficacy, or rank. /resource/api/v1.7/candidate-dmd-statistical-bridge/candidate-summary.json ZFP69B heterogeneity_and_alignment CROSS_SOURCE_SUMMARY HepG2 source response and cross-context DMD pathway projection cascade_source_direction_consistent false boolean overlapping pathways and non-independent source vectors exploratory_descriptive_summary The pooled value is descriptive and does not establish validation, rescue, efficacy, or rank. /resource/api/v1.7/candidate-dmd-statistical-bridge/candidate-summary.json ZFP69B heterogeneity_and_alignment CROSS_SOURCE_SUMMARY HepG2 source response and cross-context DMD pathway projection cascade_correction_alignment_spearman -0.05739240042925521 rho overlapping pathways and non-independent source vectors exploratory_descriptive_summary The pooled value is descriptive and does not establish validation, rescue, efficacy, or rank. /resource/api/v1.7/candidate-dmd-statistical-bridge/candidate-summary.json ZFP69B governance_boundary BRIDGE_PROJECTION_STATE HepG2 source response and cross-context DMD pathway projection decision_state ABSTAIN_OR_VALIDATE_IN_DMD_PERTURB_SEQ state one governed candidate L2_CROSS_CONTEXT_NETWORK_HYPOTHESIS_ONLY Bridge projection state only; it does not override the governed current action or create a rank. /resource/api/v1.7/candidate-dmd-statistical-bridge/candidate-summary.json ZFP69B governance_boundary ABSTENTION_REASONS HepG2 source response and cross-context DMD pathway projection abstention_reasons weak_split_half_measurement;skeletal_muscle_tpm_le_1;correction_alignment_not_positive;target_engagement_coordinate_missing_or_not_suppressed semicolon-delimited reasons one governed candidate recorded A missing additional reason does not unlock validation; disease-matched candidate evidence is still required. /resource/api/v1.7/candidate-dmd-statistical-bridge/candidate-summary.json ZFP69B governance_boundary DMD_CANDIDATE_TRUTH HepG2 source response and cross-context DMD pathway projection measured_dmd_candidate_truth 0/21 candidate outcomes 21 governed candidates locked Cross-context projection is not measured candidate response in DMD muscle. /resource/api/v1.7/candidate-dmd-statistical-bridge/candidate-summary.json ZFP69B governance_boundary VALIDATED_PREDICTIONS HepG2 source response and cross-context DMD pathway projection validated_candidate_level_dmd_pathway_predictions 0 predictions 21 governed candidates locked No candidate-level DMD pathway prediction has been validated. /resource/api/v1.7/candidate-dmd-statistical-bridge/candidate-summary.json