gene section dataset_or_field context metric value unit denominator status interpretation source_url DNM1 dataset_evidence HEPG2_CRISPRI_FROZEN_AGGREGATE HepG2; CRISPRi; non-muscle, non-DMD context observed_cells 116 cells 116 cells measured Observed perturbation coverage in HepG2. The cells are not independent biological replicates and do not establish a DMD effect. /resource/perturbation/DNM1/ DNM1 dataset_evidence GTEX_V8_SKELETAL_MUSCLE Human skeletal muscle tissue median_tpm 1.39988 TPM 1 contexts; row count unavailable context_only Tissue expression supports assay feasibility only; it does not establish cell-type expression, function or perturbation response. /resource/api/v1.1/core-gene/DNM1 DNM1 dataset_evidence DEPMAP_CONTEXT_METRIC DepMap cell-line dependency context; not muscle-specific median_gene_effect -0.2192872843255425 DepMap gene-effect score context_only A broad dependency context metric. It is not a safety result and is not evidence of disease-selective dependency. /resource/api/v1.1/core-gene/DNM1 DNM1 dataset_evidence HEPG2_CONTEXT_RELATIONSHIP_V06 Same processed HepG2 perturbation substrate observed_counteralignment 0.0023798166472955 unitless score 116 cells contributing to the target aggregate context_only A descriptive relationship within the same processed context; it is not therapeutic rescue or an independently validated effect. /resource/perturbation/DNM1/ DNM1 dataset_evidence DMD single-cell baseline pseudobulk DMD skeletal-muscle single-cell source; baseline pseudobulk summaries median_source_effect -0.0869047166382403 source-specific effect scale 14 contexts; 14 rows context_only Observed-expression source summary; contextual evidence rather than candidate perturbation truth. /resource/api/v1.2/dmd-prior/genes/DNM1.json DNM1 dataset_evidence DMD single-cell delta / DID DMD skeletal-muscle single-cell source; final-label delta / DID summaries median_source_effect 0.17846150700848115 source-specific effect scale 14 contexts; 14 rows context_only Observed-expression source summary; contextual evidence rather than candidate perturbation truth. /resource/api/v1.2/dmd-prior/genes/DNM1.json DNM1 dataset_evidence SEMA3C DESeq2 source-state DMD skeletal-muscle source-state analysis median_source_effect 0.15394599554472 source-specific effect scale 9 contexts; 9 rows context_only Observed-expression source summary; contextual evidence rather than candidate perturbation truth. /resource/api/v1.2/dmd-prior/genes/DNM1.json DNM1 dataset_evidence SEMA3C NicheNet target-state DMD skeletal-muscle regulatory-inference context median_source_effect -0.2596630446475791 source-specific effect scale 1 contexts; 1 rows context_only Regulatory-inference channel; displayed separately and not pooled as an independent expression cohort. /resource/api/v1.2/dmd-prior/genes/DNM1.json DNM1 measured_source_context HEPG2_CANDIDATE_CELLS HepG2 source response and cross-context DMD pathway projection candidate_cells 116 cells 4976 control cells cell_level_exploratory Cell coverage without a biological-replicate column; not donor-level or disease-level inference. /resource/api/v1.7/candidate-dmd-statistical-bridge/candidate-summary.json DNM1 measured_source_context TARGET_GENE_DELTA HepG2 source response and cross-context DMD pathway projection target_gene_delta normalized expression delta target-gene coordinate not_measured Target-gene delta is missing, not zero. /resource/api/v1.7/candidate-dmd-statistical-bridge/candidate-summary.json DNM1 measured_source_context CELL_LEVEL_DE HepG2 source response and cross-context DMD pathway projection fdr_lt_0_05_abs_delta_ge_0_1 5 rows 25 rows at cell-level FDR < 0.05 cell_level_exploratory No biological-replicate column; donor-level and disease-level inference are blocked. /resource/api/v1.7/candidate-dmd-statistical-bridge/candidate-summary.json DNM1 measured_source_context REACTOME_CAMERA HepG2 source response and cross-context DMD pathway projection robust_camera_pathways 49 pathways 1378 tested; 49 up; 0 down source_context_only Competitive pathway tests in the source context do not establish a candidate response in DMD muscle. /resource/api/v1.7/candidate-dmd-statistical-bridge/candidate-summary.json DNM1 cross_context_dmd_projection GSE233606 separately measured DMD pathway axis direct_projection_spearman -0.02789841260922683 rho 1360 pathways exploratory_context_only Not a measured candidate response in DMD muscle; source vectors are not independent studies. https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE233606 DNM1 cross_context_dmd_projection GSE233606 separately measured DMD pathway axis cascade_projection_spearman 0.06413661861250348 rho 1360 pathways exploratory_context_only Not a measured candidate response in DMD muscle; source vectors are not independent studies. https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE233606 DNM1 cross_context_dmd_projection GSE272233 separately measured DMD pathway axis direct_projection_spearman -0.12797133415242926 rho 1320 pathways exploratory_context_only Not a measured candidate response in DMD muscle; source vectors are not independent studies. https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE272233 DNM1 cross_context_dmd_projection GSE272233 separately measured DMD pathway axis cascade_projection_spearman -0.0759180680185973 rho 1320 pathways exploratory_context_only Not a measured candidate response in DMD muscle; source vectors are not independent studies. https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE272233 DNM1 cross_context_dmd_projection GSE277637 separately measured DMD pathway axis direct_projection_spearman 0.02119097902719678 rho 1360 pathways exploratory_context_only Not a measured candidate response in DMD muscle; source vectors are not independent studies. https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE277637 DNM1 cross_context_dmd_projection GSE277637 separately measured DMD pathway axis cascade_projection_spearman 0.0704876052559995 rho 1360 pathways exploratory_context_only Not a measured candidate response in DMD muscle; source vectors are not independent studies. https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE277637 DNM1 heterogeneity_and_alignment CROSS_SOURCE_SUMMARY HepG2 source response and cross-context DMD pathway projection pooled_rescue_spearman -0.04427144788033064 rho overlapping pathways and non-independent source vectors exploratory_descriptive_summary The pooled value is descriptive and does not establish validation, rescue, efficacy, or rank. /resource/api/v1.7/candidate-dmd-statistical-bridge/candidate-summary.json DNM1 heterogeneity_and_alignment CROSS_SOURCE_SUMMARY HepG2 source response and cross-context DMD pathway projection cochran_q 15.561878569353004 Q overlapping pathways and non-independent source vectors exploratory_descriptive_summary The pooled value is descriptive and does not establish validation, rescue, efficacy, or rank. /resource/api/v1.7/candidate-dmd-statistical-bridge/candidate-summary.json DNM1 heterogeneity_and_alignment CROSS_SOURCE_SUMMARY HepG2 source response and cross-context DMD pathway projection i2_percent 87.14808118385703 percent overlapping pathways and non-independent source vectors exploratory_descriptive_summary The pooled value is descriptive and does not establish validation, rescue, efficacy, or rank. /resource/api/v1.7/candidate-dmd-statistical-bridge/candidate-summary.json DNM1 heterogeneity_and_alignment CROSS_SOURCE_SUMMARY HepG2 source response and cross-context DMD pathway projection source_direction_consistent false boolean overlapping pathways and non-independent source vectors exploratory_descriptive_summary The pooled value is descriptive and does not establish validation, rescue, efficacy, or rank. /resource/api/v1.7/candidate-dmd-statistical-bridge/candidate-summary.json DNM1 heterogeneity_and_alignment CROSS_SOURCE_SUMMARY HepG2 source response and cross-context DMD pathway projection correction_alignment_spearman -0.2581982929996381 rho overlapping pathways and non-independent source vectors exploratory_descriptive_summary The pooled value is descriptive and does not establish validation, rescue, efficacy, or rank. /resource/api/v1.7/candidate-dmd-statistical-bridge/candidate-summary.json DNM1 heterogeneity_and_alignment CROSS_SOURCE_SUMMARY HepG2 source response and cross-context DMD pathway projection cascade_pooled_rescue_spearman 0.02053463303065301 rho overlapping pathways and non-independent source vectors exploratory_descriptive_summary The pooled value is descriptive and does not establish validation, rescue, efficacy, or rank. /resource/api/v1.7/candidate-dmd-statistical-bridge/candidate-summary.json DNM1 heterogeneity_and_alignment CROSS_SOURCE_SUMMARY HepG2 source response and cross-context DMD pathway projection cascade_cochran_q 18.281719932561415 Q overlapping pathways and non-independent source vectors exploratory_descriptive_summary The pooled value is descriptive and does not establish validation, rescue, efficacy, or rank. /resource/api/v1.7/candidate-dmd-statistical-bridge/candidate-summary.json DNM1 heterogeneity_and_alignment CROSS_SOURCE_SUMMARY HepG2 source response and cross-context DMD pathway projection cascade_i2_percent 89.06011027749192 percent overlapping pathways and non-independent source vectors exploratory_descriptive_summary The pooled value is descriptive and does not establish validation, rescue, efficacy, or rank. /resource/api/v1.7/candidate-dmd-statistical-bridge/candidate-summary.json DNM1 heterogeneity_and_alignment CROSS_SOURCE_SUMMARY HepG2 source response and cross-context DMD pathway projection cascade_source_direction_consistent false boolean overlapping pathways and non-independent source vectors exploratory_descriptive_summary The pooled value is descriptive and does not establish validation, rescue, efficacy, or rank. /resource/api/v1.7/candidate-dmd-statistical-bridge/candidate-summary.json DNM1 heterogeneity_and_alignment CROSS_SOURCE_SUMMARY HepG2 source response and cross-context DMD pathway projection cascade_correction_alignment_spearman -0.2073099549360061 rho overlapping pathways and non-independent source vectors exploratory_descriptive_summary The pooled value is descriptive and does not establish validation, rescue, efficacy, or rank. /resource/api/v1.7/candidate-dmd-statistical-bridge/candidate-summary.json DNM1 governance_boundary BRIDGE_PROJECTION_STATE HepG2 source response and cross-context DMD pathway projection decision_state ABSTAIN_OR_VALIDATE_IN_DMD_PERTURB_SEQ state one governed candidate L2_CROSS_CONTEXT_NETWORK_HYPOTHESIS_ONLY Bridge projection state only; it does not override the governed current action or create a rank. /resource/api/v1.7/candidate-dmd-statistical-bridge/candidate-summary.json DNM1 governance_boundary ABSTENTION_REASONS HepG2 source response and cross-context DMD pathway projection abstention_reasons correction_alignment_not_positive;target_engagement_coordinate_missing_or_not_suppressed semicolon-delimited reasons one governed candidate recorded A missing additional reason does not unlock validation; disease-matched candidate evidence is still required. /resource/api/v1.7/candidate-dmd-statistical-bridge/candidate-summary.json DNM1 governance_boundary DMD_CANDIDATE_TRUTH HepG2 source response and cross-context DMD pathway projection measured_dmd_candidate_truth 0/21 candidate outcomes 21 governed candidates locked Cross-context projection is not measured candidate response in DMD muscle. /resource/api/v1.7/candidate-dmd-statistical-bridge/candidate-summary.json DNM1 governance_boundary VALIDATED_PREDICTIONS HepG2 source response and cross-context DMD pathway projection validated_candidate_level_dmd_pathway_predictions 0 predictions 21 governed candidates locked No candidate-level DMD pathway prediction has been validated. /resource/api/v1.7/candidate-dmd-statistical-bridge/candidate-summary.json