# Figure package v09.80: all main figures with source-bound Figure 3 installed

## Installed Figure 3 caption

**Figure 3. Candidate provenance and source-bound assignment audit define a bounded pilot stratum without DMD validation.**  
**a,** The DMD candidate lineage starts at the first checksum-addressed recoverable checkpoint: a historical 58-candidate source queue is reported, but the original source TSV and full replay manifest are unavailable, so the retained 21-row vector is treated as an inherited hypothesis set rather than a new genome-wide discovery result.  
**b,** Coverage and endpoint evidence remain distinct: 21 of 21 candidates have source-context responses and pass the HepG2 coverage floor; 9 of 21 are covered by an independent healthy-myoblast fusion screen, 0 of 9 are fusion-defect hits, and 12 of 21 are not measured in that endpoint.  
**c,** Five dependent local audit rules summarize current assignment. Seven of 21 candidates pass repeated-resampling stability, 16 of 21 pass bulk skeletal-muscle expression feasibility, 14 of 21 pass cross-context dependency caution, 11 of 21 pass DMD-source projection, and 12 of 21 pass target-engagement margin. The repeated-resampling and target-engagement-margin counts are taken from the locked v08.5 rule-freeze table, whereas the muscle-expression, dependency-caution and DMD-source-projection counts are taken from the current candidate network summary; these are dependent audit filters, not independent validation streams. ADAM10, CALR and MPHOSPH6 pass all five and form the current 3-of-21 pilot stratum; the remaining 18 receive reason-coded abstentions.  
**d,** Direct-seed, no-propagation and RWR graph models are numerically distinct but converge on the same current pilot set.  
**Guardrail.** This figure shows provenance recovery, source-context adequacy and conditional assignment robustness. It does not show candidate responses measured in DMD muscle, therapeutic efficacy, safety, clinical utility or functional validation.

## Package contents

- `figures/`: six main figures, each provided as PDF/PNG/SVG/TIFF under v09.80 stems.
- `MAIN_FIGURE_CAPTION_BOOK_v09_80.md`: journal-facing caption book.
- `MAIN_FIGURE_LATEX_INCLUDE_v09_80.tex`: LaTeX include block with v09.80 filenames.
- `NMD_VCell_ScienceAdvances_Manuscript_v09_80_FIGURE3_AUDIT_MATRIX_SYNCED.md`: manuscript candidate with Figure 3 caption and Results source-binding patch.
- `results/v09_80_figure_table_trace.json`: ARS Figure/Table Trace for all six contained figures.

## Gate summary

- `main_figure_files`: PASS — 24/24 expected PDF/PNG/SVG/TIFF files copied under v09.80 stems
- `manuscript_panel_callouts`: PASS — all expected main-text panel callouts found with caption section excluded
- `figure3_audit_matrix_install`: PASS — v09.79 Figure 3 audit-matrix redraw installed as Figure_3_candidate_assignment_audit_matrix_v09_80.*
- `figure3_caption_source_binding`: PASS — Figure 3 caption contains v08.5 rule-freeze/current-network source-binding and dependency warning
- `figure3_results_source_binding`: PASS — Figure 3 Results paragraph contains matching source-binding sentence
- `figure_table_trace`: PASS — all six figure entries include ARS-required source_data/transformation/caption_claim/supported_claims/limitations keys
- `all_other_main_figures_carried_forward`: PASS — Figures 1, 2, 4, 5 and 6 copied forward from the v09.38 synced all-main packet without visual mutation
- `central_manuscript_overwrite`: NOT_APPLIED — v09.80 writes a new manuscript candidate inside the packet and does not overwrite the central v09.70/v09.38 lineage files
- `administrative_submission_package`: BLOCKED — scientific figure/caption/trace packet ready; administrative release, citation, author, and journal formatting gates remain outside this builder

## Figure/Table Trace status

- `Figure_1_Figure_1_evidence_governance_v09_80_trace_v09_80`: PASS
- `Figure_2_Figure_2_dmd_axes_v09_80_trace_v09_80`: PASS
- `Figure_3_Figure_3_candidate_assignment_audit_matrix_v09_80_trace_v09_80`: PASS
- `Figure_4_Figure_4_boundary_holdout_v09_80_trace_v09_80`: PASS
- `Figure_5_Figure_5_disease_module_matrix_v09_80_trace_v09_80`: PASS
- `Figure_6_Figure_6_single_cell_extensions_v09_80_trace_v09_80`: PASS

## Replacement boundary

The old v09.38/v09.33 Figure 3 boundary graphic is retained as a lineage artifact. The v09.80 packet should be treated as the next replacement candidate, not as an overwrite of the central manuscript source until author visual approval and release/deploy promotion are complete.