stage_id	title	state	deliverable	acceptance_gate	no_shortcut	advantage_unlocked
MOAT-00	Trust infrastructure	IMPLEMENTED	Typed evidence, model and reliability contracts with negative-result preservation.	Every claim has provenance, execution state, failure state, ceiling and next gate.	Do not replace explicit states with a synthetic trust score.	Auditable research decision support.
MOAT-01	Matched DMD perturbation pilot	BLOCKED_EXTERNAL_EXPERIMENT	Candidate-conditioned DMD myogenic perturbation outcomes with independent biological units, molecular and functional readouts.	Frozen estimand, controls, donor/culture units, QC, toxicity and complete outcome return.	Do not substitute healthy myoblast, HepG2 or unperturbed DMD context.	First proprietary disease-task truth and model eligibility.
MOAT-02	Donor-resolved benchmark	PENDING_MOAT_01	Leakage-safe donor, state and perturbation holdouts with permanent simple baselines.	Perturbation-specific, population, calibration and functional layers pass prospectively.	Cells cannot be treated as independent donors and mean RMSE cannot be the only metric.	Defensible NMD generalization evidence.
MOAT-03	Prospective learning loop	PENDING_MOAT_02	Registered predictions whose positive, null, toxic and failed outcomes return to the same evidence graph.	Immutable preregistration, blinded evaluation, calibration and independent replication.	Retrospective fit cannot be relabeled as prospective validation.	Compounding proprietary evidence and a genuinely exercised closed loop.