{ "comparison_schema": "nmd-vcell-comparison-object/1.1", "comparison_id": "CMP-20260726-61BB5BEE5251", "key": "replication", "title": "Computational-replication queue", "payload_sha256": "61bb5bee525128e470584b8361eadf2be2619411594f77457061c90d431a009a", "resource_release": "v1.0.0-database-resource", "schema_version": "1.1", "research_object_schema": "1.3", "evidence_freeze": "2026-07-25", "interface_build": "EA-20260726-13", "generated_at": "2026-07-26T00:00:00.000Z", "original_input_identifiers": [ "INTS13", "NAGLU", "RNF8" ], "identifier_mapping": { "source": { "licence": "CC0", "retrieved_at": "2026-07-25", "sha256": "41fe4d55110b22ac3a4c2579d281b0fcf51f18c0b622b0f88f45d49bb2c0d9fb", "snapshot_sha256": "272ebb642268184c6a4baeb0de9ffc6a87ea1baf96f2a286fcb07d78f1dd93c5", "url": "https://storage.googleapis.com/public-download-files/hgnc/tsv/tsv/hgnc_complete_set.txt" }, "retrieved_at": "2026-07-25" }, "ranking_generated": false, "lifecycle": { "state": "RELEASED", "revision": 1, "immutable": true, "registered_at": "2026-07-26T00:00:00.000Z", "supersedes": null }, "rows": [ { "input_identifiers": [ "INTS13" ], "normalized_symbol": "INTS13", "mapping_status": "approved_symbol", "mapping_source": "HGNC HGNC:20174", "mapping_candidates": [ "INTS13" ], "gene": "INTS13", "record": { "gene": "INTS13", "identifiers": { "hgnc_id": "HGNC:20174", "ensembl_gene_id": "ENSG00000064102", "ncbi_gene_id": 55726 }, "decision": { "current_action": "risk_review", "current_display_label": "Risk/context review", "formal_deprioritization": false }, "highest_supported_level": "L2_observed_same_context_perturbation", "highest_assessed_level": "L2_observed_same_context_perturbation", "dmd_context": { "integrated_prior_direction": "up", "source_direction_state": "consistent_up", "source_direction_agreement": { "agreeing_sources": 4, "assessed_sources": 4, "directional_sources": 4, "proportion": 1 }, "variant_stability_state": "sign_varied_across_variants", "variant_count": 9, "evidence_module_memberships": [ "exploratory_multisource_core" ], "statistical_support_state": "direction_only_no_significant_context_rows", "coverage_state": "4_of_4_sources", "integration_method": "median signed score across significant context rows when present, otherwise across all available context rows; 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source-level directions are audited separately", "uncertainty_state": "direction_conflict_retained", "conflict_reason": "2 source(s) positive and 2 source(s) negative", "integrated_direction_is_prior_not_ground_truth": true, "consensus_direction": "up_in_dmd", "consensus_direction_deprecation": { "deprecated": true, "replacement": "integrated_prior_direction", "policy": "retained for one schema cycle; do not interpret as study consensus" } }, "evidence_status": { "resource_record": { "assessment_status": "assessed", "support_status": "supported" }, "observed_hepg2_perturbation": { "assessment_status": "assessed", "support_status": "supported", "observed_cells": 122 }, "internal_model_support": { "assessment_status": "assessed", "support_status": "supported_with_limits", "target_specific_predictive_support": "not_supported", "ood_status": "not_assessed", "context": "same_processed_hepg2_dataset" }, "external_context_screen": { "assessment_status": "not_assessed", "hit": null }, "independent_perturbation_replication": { "assessment_status": "not_assessed" }, "dmd_muscle_validation": { "assessment_status": "not_assessed" }, "functional_validation": { "assessment_status": "not_assessed" }, "therapeutic_utility": { "assessment_status": "not_assessed" } }, "context_metrics": { "skeletal_muscle_median_tpm": 4.10534, "moderate_dependency_flag": true }, "evidence_gaps": { "decision_blocking_gap": { "code": "GAP-08", "label": "Safety and dependency context blocks escalation" }, "highest_missing_evidence_layer": "L4_dmd_functional_validation", "secondary_gaps": [ "GAP-02 independent muscle-context perturbation", "GAP-03 DMD-relevant functional validation", "GAP-07 independent replication" ] }, "has_detailed_audit_record": true } } ], "claim_boundary": "This comparison preserves evidence dimensions and missingness. It does not create a composite score, ranking, causal claim or therapeutic recommendation.", "stable_url": "comparison/CMP-20260726-61BB5BEE5251/" }