{
  "disease": "SMA",
  "datasets": [
    {
      "accession": "GSE290979",
      "model": "Human SMA type I spinal-cord organoids",
      "design": "31 bulk RNA-seq samples; 3 control and 2 SMA donor-derived lines",
      "state": "MEASURED+INTERVENTION_RESPONSE",
      "role": "Disease and R6-MO / scramble response at line level",
      "url": "https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE290979"
    },
    {
      "accession": "GSE290980",
      "model": "Matched spinal/cerebral organoid single-cell data",
      "design": "8 single-cell libraries; registered as cell-resolution companion",
      "state": "REGISTERED",
      "role": "Neural cell-state reference",
      "url": "https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE290980"
    },
    {
      "accession": "GSE252128",
      "model": "Treated type II SMA paravertebral muscle",
      "design": "8 treated SMA vs 7 controls",
      "state": "MEASURED_DIRECTIONAL",
      "role": "Residual OXPHOS, denervation and fibrosis hypotheses; all module q>0.30 here",
      "url": "https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE252128"
    },
    {
      "accession": "GSE302774",
      "model": "Human motor and cortical neurons after SMN knockdown",
      "design": "3 replicates per condition in each neural context",
      "state": "PERTURBED",
      "role": "Orthogonal KIF5A downstream mechanism evidence",
      "url": "https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE302774"
    }
  ]
}