{
  "disease": "FSHD",
  "records": [
    {
      "disease": "FSHD",
      "candidate_or_module": "DUX4",
      "role": "etiologic_anchor",
      "establishment_basis": "causal_genetic_and_induced_timecourse",
      "evidence_state": "INDUCED",
      "permitted_interpretation": "Disease-initiating transcription factor; not a ranked output"
    },
    {
      "disease": "FSHD",
      "candidate_or_module": "DUXA",
      "role": "state_marker",
      "establishment_basis": "patient_target_module_and_induced_timecourse",
      "evidence_state": "MEASURED+INDUCED",
      "permitted_interpretation": "Downstream state marker; not therapeutic validation"
    },
    {
      "disease": "FSHD",
      "candidate_or_module": "ZSCAN4",
      "role": "state_marker",
      "establishment_basis": "patient_target_module_and_induced_timecourse",
      "evidence_state": "MEASURED+INDUCED",
      "permitted_interpretation": "Downstream state marker; not therapeutic validation"
    },
    {
      "disease": "FSHD",
      "candidate_or_module": "LEUTX",
      "role": "state_marker",
      "establishment_basis": "patient_target_module_and_induced_timecourse",
      "evidence_state": "MEASURED+INDUCED",
      "permitted_interpretation": "Downstream state marker; not therapeutic validation"
    },
    {
      "disease": "FSHD",
      "candidate_or_module": "MAPK8",
      "role": "intervention_node",
      "establishment_basis": "source_reported_JNK_inhibition_mitigates_DUX4_cell_death",
      "evidence_state": "SOURCE_INTERVENTION",
      "permitted_interpretation": "Experiment-design node; no patient efficacy claim"
    },
    {
      "disease": "FSHD",
      "candidate_or_module": "MAPK14",
      "role": "intervention_node",
      "establishment_basis": "source_reported_p38_inhibition_mitigates_DUX4_cell_death",
      "evidence_state": "SOURCE_INTERVENTION",
      "permitted_interpretation": "Experiment-design node; no patient efficacy claim"
    }
  ]
}