{
  "schema": "nmd-vcell-dataset-registry/2.0",
  "module_release": "multidisease-evidence-v0.2.0",
  "disease_id": "DMD",
  "datasets": [
    {
      "dataset_id": "NMDVCELL:DMD:DATASET:GSE233606",
      "accession": "GSE233606",
      "model": "human single-cell RNA-seq",
      "design": "healthy; patient DMD; engineered DMD; 3566 cells",
      "state": "MEASURED",
      "qualifiers": [
        "DESCRIPTIVE_OR_DIRECTIONAL"
      ],
      "role": "measured DMD induction and patient-line replication",
      "statistical_unit": "one line per condition",
      "contrast": "healthy; patient DMD; engineered DMD",
      "effect_definition": "descriptive unselected gene-axis concordance",
      "provenance_url": "/resource/api/v1.6/measured-dmd-evidence/external-validation.json"
    },
    {
      "dataset_id": "NMDVCELL:DMD:DATASET:PRJNA772047",
      "accession": "PRJNA772047",
      "model": "human single-nucleus RNA-seq pseudobulk",
      "design": "3 DMD; 2 Normal; 8776 nuclei; 5 pseudobulks",
      "state": "MEASURED",
      "qualifiers": [],
      "role": "independent patient-muscle pathway replication",
      "statistical_unit": "5 reported donors/samples",
      "contrast": "3 DMD; 2 Normal",
      "effect_definition": "sample-level pathway association",
      "provenance_url": "/resource/api/v1.6/measured-dmd-evidence/external-validation.json"
    },
    {
      "dataset_id": "NMDVCELL:DMD:DATASET:PRJNA1218493",
      "accession": "PRJNA1218493",
      "model": "human single-cell/nucleus RNA-seq pseudobulk",
      "design": "2 DMD; 1 Normal; 7439 cells; 3 pseudobulks",
      "state": "MEASURED",
      "qualifiers": [
        "DESCRIPTIVE_OR_DIRECTIONAL"
      ],
      "role": "external disease-direction sensitivity",
      "statistical_unit": "3 reported samples",
      "contrast": "2 DMD; 1 Normal",
      "effect_definition": "directional sensitivity only",
      "provenance_url": "/resource/api/v1.6/measured-dmd-evidence/external-validation.json"
    },
    {
      "dataset_id": "NMDVCELL:DMD:DATASET:GSE156497",
      "accession": "GSE156497",
      "model": "mouse single-cell RNA-seq pseudobulk",
      "design": "1 DMD-like; 1 WT; 11581 cells; 2 pseudobulks",
      "state": "MEASURED",
      "qualifiers": [
        "DESCRIPTIVE_OR_DIRECTIONAL"
      ],
      "role": "cross-species disease-direction sensitivity",
      "statistical_unit": "2 reported samples",
      "contrast": "1 DMD-like; 1 WT",
      "effect_definition": "descriptive direction only",
      "provenance_url": "/resource/api/v1.6/measured-dmd-evidence/external-validation.json"
    },
    {
      "dataset_id": "NMDVCELL:DMD:DATASET:GSE272233",
      "accession": "GSE272233",
      "model": "human bulk RNA-seq",
      "design": "WT; 3 DMD duplication backgrounds; corrected clones; 21 samples",
      "state": "CORRECTED",
      "qualifiers": [
        "DMD_LOCUS_CORRECTION"
      ],
      "role": "measured DMD-locus CRISPR correction",
      "statistical_unit": "3 reported biological repeats per group",
      "contrast": "WT; 3 DMD duplication backgrounds; corrected clones",
      "effect_definition": "background-specific correction response",
      "provenance_url": "/resource/api/v1.6/measured-dmd-evidence/gse272233-reactome.json"
    },
    {
      "dataset_id": "NMDVCELL:DMD:DATASET:GSE277637",
      "accession": "GSE277637",
      "model": "human organoid single-cell RNA-seq pseudobulk",
      "design": "3 DMD patient lines; 1 WT line; 10480 cells; 4 pseudobulks",
      "state": "MEASURED",
      "qualifiers": [
        "DESCRIPTIVE_OR_DIRECTIONAL"
      ],
      "role": "model-system heterogeneity stress test",
      "statistical_unit": "4 lines with one shared WT",
      "contrast": "3 DMD patient lines; 1 WT line",
      "effect_definition": "line-specific descriptive effects",
      "provenance_url": "/resource/api/v1.6/measured-dmd-evidence/external-validation.json"
    },
    {
      "dataset_id": "NMDVCELL:DMD:DATASET:PROSPECTIVE_CANDIDATE_PERTURBSEQ",
      "accession": "PROSPECTIVE-CANDIDATE-PERTURBSEQ",
      "model": "DMD-relevant muscle perturbation experiment",
      "design": "21 candidates; matched controls and functional endpoints prespecified; outcomes not yet observed",
      "state": "MISSING",
      "qualifiers": [
        "PRESPECIFIED",
        "ZERO_OF_21_CANDIDATE_RESPONSES_OBSERVED"
      ],
      "role": "candidate-level DMD response truth",
      "statistical_unit": "future independent biological replicate / donor or line",
      "contrast": "candidate perturbation versus matched control",
      "effect_definition": "candidate response and rescue with uncertainty",
      "provenance_url": "/resource/api/v1.6/measured-dmd-evidence/candidate-truth-boundary.json"
    }
  ]
}