{
  "schema": "nmd-vcell-candidate-ledger/2.0",
  "module_release": "multidisease-evidence-v0.2.0",
  "disease_id": "DMD",
  "records": [
    {
      "candidate_id": "NMDVCELL:DMD:CANDIDATE:CPEB1",
      "record_version": 2,
      "disease_id": "DMD",
      "label": "CPEB1",
      "entity_type": "gene",
      "identifiers": {
        "approved_symbol": "CPEB1",
        "hgnc_id": "HGNC:21744",
        "ensembl_gene_id": "ENSG00000214575",
        "ncbi_gene_id": 64506
      },
      "role": "prospective_candidate",
      "state": "PREDICTED",
      "qualifiers": [
        "HYPOTHESIS_TRIAGE",
        "NEXT_ACTION_QUEUE",
        "NO_MEASURED_DMD_CANDIDATE_RESPONSE"
      ],
      "establishment_basis": "Frozen v0.6 multisource evidence vector plus governed current action; no current numeric rank.",
      "dataset_accessions": [],
      "contrast": "candidate perturbation versus matched control in a DMD-relevant muscle model",
      "effect": {
        "estimate": null,
        "unit": null,
        "availability": "MISSING",
        "measured_dmd_candidate_response": false,
        "historical_source_context_rescue_score": "0.0118224730803746",
        "historical_context_warning": "The historical source-context score is not a DMD effect size, p-value or treatment probability."
      },
      "statistical_unit": "not yet observed for candidate-level DMD response",
      "provenance": {
        "current_record": "/resource/api/v1/candidates.json",
        "truth_boundary": "/resource/api/v1.6/measured-dmd-evidence/candidate-truth-boundary.json",
        "gap_code": "GAP-06",
        "highest_supported_level": "L2_observed_same_context_perturbation"
      },
      "next_experiment": "Verify expression in the intended DMD muscle model before perturbation.",
      "current_action": "verify_expression",
      "permitted_interpretation": "Governed prospective candidate and next action; not a validated target or treatment rank.",
      "claim_ceiling": "no_measured_candidate_level_dmd_response_or_clinical_prediction"
    },
    {
      "candidate_id": "NMDVCELL:DMD:CANDIDATE:DNAAF3",
      "record_version": 2,
      "disease_id": "DMD",
      "label": "DNAAF3",
      "entity_type": "gene",
      "identifiers": {
        "approved_symbol": "DNAAF3",
        "hgnc_id": "HGNC:30492",
        "ensembl_gene_id": "ENSG00000167646",
        "ncbi_gene_id": 352909
      },
      "role": "prospective_candidate",
      "state": "PREDICTED",
      "qualifiers": [
        "HYPOTHESIS_TRIAGE",
        "NEXT_ACTION_QUEUE",
        "NO_MEASURED_DMD_CANDIDATE_RESPONSE"
      ],
      "establishment_basis": "Frozen v0.6 multisource evidence vector plus governed current action; no current numeric rank.",
      "dataset_accessions": [],
      "contrast": "candidate perturbation versus matched control in a DMD-relevant muscle model",
      "effect": {
        "estimate": null,
        "unit": null,
        "availability": "MISSING",
        "measured_dmd_candidate_response": false,
        "historical_source_context_rescue_score": "0.0344381820755609",
        "historical_context_warning": "The historical source-context score is not a DMD effect size, p-value or treatment probability."
      },
      "statistical_unit": "not yet observed for candidate-level DMD response",
      "provenance": {
        "current_record": "/resource/api/v1/candidates.json",
        "truth_boundary": "/resource/api/v1.6/measured-dmd-evidence/candidate-truth-boundary.json",
        "gap_code": "GAP-06",
        "highest_supported_level": "L2_observed_same_context_perturbation"
      },
      "next_experiment": "Verify expression in the intended DMD muscle model before perturbation.",
      "current_action": "verify_expression",
      "permitted_interpretation": "Governed prospective candidate and next action; not a validated target or treatment rank.",
      "claim_ceiling": "no_measured_candidate_level_dmd_response_or_clinical_prediction"
    },
    {
      "candidate_id": "NMDVCELL:DMD:CANDIDATE:EPS8L1",
      "record_version": 2,
      "disease_id": "DMD",
      "label": "EPS8L1",
      "entity_type": "gene",
      "identifiers": {
        "approved_symbol": "EPS8L1",
        "hgnc_id": "HGNC:21295",
        "ensembl_gene_id": "ENSG00000131037",
        "ncbi_gene_id": 54869
      },
      "role": "prospective_candidate",
      "state": "PREDICTED",
      "qualifiers": [
        "HYPOTHESIS_TRIAGE",
        "NEXT_ACTION_QUEUE",
        "NO_MEASURED_DMD_CANDIDATE_RESPONSE"
      ],
      "establishment_basis": "Frozen v0.6 multisource evidence vector plus governed current action; no current numeric rank.",
      "dataset_accessions": [],
      "contrast": "candidate perturbation versus matched control in a DMD-relevant muscle model",
      "effect": {
        "estimate": null,
        "unit": null,
        "availability": "MISSING",
        "measured_dmd_candidate_response": false,
        "historical_source_context_rescue_score": "0.0035653885102933",
        "historical_context_warning": "The historical source-context score is not a DMD effect size, p-value or treatment probability."
      },
      "statistical_unit": "not yet observed for candidate-level DMD response",
      "provenance": {
        "current_record": "/resource/api/v1/candidates.json",
        "truth_boundary": "/resource/api/v1.6/measured-dmd-evidence/candidate-truth-boundary.json",
        "gap_code": "GAP-06",
        "highest_supported_level": "L2_observed_same_context_perturbation"
      },
      "next_experiment": "Verify expression in the intended DMD muscle model before perturbation.",
      "current_action": "verify_expression",
      "permitted_interpretation": "Governed prospective candidate and next action; not a validated target or treatment rank.",
      "claim_ceiling": "no_measured_candidate_level_dmd_response_or_clinical_prediction"
    },
    {
      "candidate_id": "NMDVCELL:DMD:CANDIDATE:ZFP69B",
      "record_version": 2,
      "disease_id": "DMD",
      "label": "ZFP69B",
      "entity_type": "gene",
      "identifiers": {
        "approved_symbol": "ZFP69B",
        "hgnc_id": "HGNC:28053",
        "ensembl_gene_id": "ENSG00000187801",
        "ncbi_gene_id": 65243
      },
      "role": "prospective_candidate",
      "state": "PREDICTED",
      "qualifiers": [
        "HYPOTHESIS_TRIAGE",
        "NEXT_ACTION_QUEUE",
        "NO_MEASURED_DMD_CANDIDATE_RESPONSE"
      ],
      "establishment_basis": "Frozen v0.6 multisource evidence vector plus governed current action; no current numeric rank.",
      "dataset_accessions": [],
      "contrast": "candidate perturbation versus matched control in a DMD-relevant muscle model",
      "effect": {
        "estimate": null,
        "unit": null,
        "availability": "MISSING",
        "measured_dmd_candidate_response": false,
        "historical_source_context_rescue_score": "0.0563412545485794",
        "historical_context_warning": "The historical source-context score is not a DMD effect size, p-value or treatment probability."
      },
      "statistical_unit": "not yet observed for candidate-level DMD response",
      "provenance": {
        "current_record": "/resource/api/v1/candidates.json",
        "truth_boundary": "/resource/api/v1.6/measured-dmd-evidence/candidate-truth-boundary.json",
        "gap_code": "GAP-06",
        "highest_supported_level": "L2_observed_same_context_perturbation"
      },
      "next_experiment": "Verify expression in the intended DMD muscle model before perturbation.",
      "current_action": "verify_expression",
      "permitted_interpretation": "Governed prospective candidate and next action; not a validated target or treatment rank.",
      "claim_ceiling": "no_measured_candidate_level_dmd_response_or_clinical_prediction"
    },
    {
      "candidate_id": "NMDVCELL:DMD:CANDIDATE:INTS13",
      "record_version": 2,
      "disease_id": "DMD",
      "label": "INTS13",
      "entity_type": "gene",
      "identifiers": {
        "approved_symbol": "INTS13",
        "hgnc_id": "HGNC:20174",
        "ensembl_gene_id": "ENSG00000064102",
        "ncbi_gene_id": 55726
      },
      "role": "prospective_candidate",
      "state": "PREDICTED",
      "qualifiers": [
        "HYPOTHESIS_TRIAGE",
        "NEXT_ACTION_QUEUE",
        "NO_MEASURED_DMD_CANDIDATE_RESPONSE"
      ],
      "establishment_basis": "Frozen v0.6 multisource evidence vector plus governed current action; no current numeric rank.",
      "dataset_accessions": [],
      "contrast": "candidate perturbation versus matched control in a DMD-relevant muscle model",
      "effect": {
        "estimate": null,
        "unit": null,
        "availability": "MISSING",
        "measured_dmd_candidate_response": false,
        "historical_source_context_rescue_score": "0.0192678440828641",
        "historical_context_warning": "The historical source-context score is not a DMD effect size, p-value or treatment probability."
      },
      "statistical_unit": "not yet observed for candidate-level DMD response",
      "provenance": {
        "current_record": "/resource/api/v1/candidates.json",
        "truth_boundary": "/resource/api/v1.6/measured-dmd-evidence/candidate-truth-boundary.json",
        "gap_code": "GAP-08",
        "highest_supported_level": "L2_observed_same_context_perturbation"
      },
      "next_experiment": "Resolve dependency, toxicity and context-risk flags before DMD perturbation.",
      "current_action": "risk_review",
      "permitted_interpretation": "Governed prospective candidate and next action; not a validated target or treatment rank.",
      "claim_ceiling": "no_measured_candidate_level_dmd_response_or_clinical_prediction"
    },
    {
      "candidate_id": "NMDVCELL:DMD:CANDIDATE:NAGLU",
      "record_version": 2,
      "disease_id": "DMD",
      "label": "NAGLU",
      "entity_type": "gene",
      "identifiers": {
        "approved_symbol": "NAGLU",
        "hgnc_id": "HGNC:7632",
        "ensembl_gene_id": "ENSG00000108784",
        "ncbi_gene_id": 4669
      },
      "role": "prospective_candidate",
      "state": "PREDICTED",
      "qualifiers": [
        "HYPOTHESIS_TRIAGE",
        "NEXT_ACTION_QUEUE",
        "NO_MEASURED_DMD_CANDIDATE_RESPONSE"
      ],
      "establishment_basis": "Frozen v0.6 multisource evidence vector plus governed current action; no current numeric rank.",
      "dataset_accessions": [],
      "contrast": "candidate perturbation versus matched control in a DMD-relevant muscle model",
      "effect": {
        "estimate": null,
        "unit": null,
        "availability": "MISSING",
        "measured_dmd_candidate_response": false,
        "historical_source_context_rescue_score": "0.011015441933206",
        "historical_context_warning": "The historical source-context score is not a DMD effect size, p-value or treatment probability."
      },
      "statistical_unit": "not yet observed for candidate-level DMD response",
      "provenance": {
        "current_record": "/resource/api/v1/candidates.json",
        "truth_boundary": "/resource/api/v1.6/measured-dmd-evidence/candidate-truth-boundary.json",
        "gap_code": "GAP-08",
        "highest_supported_level": "L2_observed_same_context_perturbation"
      },
      "next_experiment": "Resolve dependency, toxicity and context-risk flags before DMD perturbation.",
      "current_action": "risk_review",
      "permitted_interpretation": "Governed prospective candidate and next action; not a validated target or treatment rank.",
      "claim_ceiling": "no_measured_candidate_level_dmd_response_or_clinical_prediction"
    },
    {
      "candidate_id": "NMDVCELL:DMD:CANDIDATE:RAC3",
      "record_version": 2,
      "disease_id": "DMD",
      "label": "RAC3",
      "entity_type": "gene",
      "identifiers": {
        "approved_symbol": "RAC3",
        "hgnc_id": "HGNC:9803",
        "ensembl_gene_id": "ENSG00000169750",
        "ncbi_gene_id": 5881
      },
      "role": "prospective_candidate",
      "state": "PREDICTED",
      "qualifiers": [
        "HYPOTHESIS_TRIAGE",
        "NEXT_ACTION_QUEUE",
        "NO_MEASURED_DMD_CANDIDATE_RESPONSE"
      ],
      "establishment_basis": "Frozen v0.6 multisource evidence vector plus governed current action; no current numeric rank.",
      "dataset_accessions": [],
      "contrast": "candidate perturbation versus matched control in a DMD-relevant muscle model",
      "effect": {
        "estimate": null,
        "unit": null,
        "availability": "MISSING",
        "measured_dmd_candidate_response": false,
        "historical_source_context_rescue_score": "0.0247824419731771",
        "historical_context_warning": "The historical source-context score is not a DMD effect size, p-value or treatment probability."
      },
      "statistical_unit": "not yet observed for candidate-level DMD response",
      "provenance": {
        "current_record": "/resource/api/v1/candidates.json",
        "truth_boundary": "/resource/api/v1.6/measured-dmd-evidence/candidate-truth-boundary.json",
        "gap_code": "GAP-08",
        "highest_supported_level": "L2_observed_same_context_perturbation"
      },
      "next_experiment": "Resolve dependency, toxicity and context-risk flags before DMD perturbation.",
      "current_action": "risk_review",
      "permitted_interpretation": "Governed prospective candidate and next action; not a validated target or treatment rank.",
      "claim_ceiling": "no_measured_candidate_level_dmd_response_or_clinical_prediction"
    },
    {
      "candidate_id": "NMDVCELL:DMD:CANDIDATE:RNASEH2C",
      "record_version": 2,
      "disease_id": "DMD",
      "label": "RNASEH2C",
      "entity_type": "gene",
      "identifiers": {
        "approved_symbol": "RNASEH2C",
        "hgnc_id": "HGNC:24116",
        "ensembl_gene_id": "ENSG00000172922",
        "ncbi_gene_id": 84153
      },
      "role": "prospective_candidate",
      "state": "PREDICTED",
      "qualifiers": [
        "HYPOTHESIS_TRIAGE",
        "NEXT_ACTION_QUEUE",
        "NO_MEASURED_DMD_CANDIDATE_RESPONSE"
      ],
      "establishment_basis": "Frozen v0.6 multisource evidence vector plus governed current action; no current numeric rank.",
      "dataset_accessions": [],
      "contrast": "candidate perturbation versus matched control in a DMD-relevant muscle model",
      "effect": {
        "estimate": null,
        "unit": null,
        "availability": "MISSING",
        "measured_dmd_candidate_response": false,
        "historical_source_context_rescue_score": "0.0216855909190419",
        "historical_context_warning": "The historical source-context score is not a DMD effect size, p-value or treatment probability."
      },
      "statistical_unit": "not yet observed for candidate-level DMD response",
      "provenance": {
        "current_record": "/resource/api/v1/candidates.json",
        "truth_boundary": "/resource/api/v1.6/measured-dmd-evidence/candidate-truth-boundary.json",
        "gap_code": "GAP-08",
        "highest_supported_level": "L2_observed_same_context_perturbation"
      },
      "next_experiment": "Resolve dependency, toxicity and context-risk flags before DMD perturbation.",
      "current_action": "risk_review",
      "permitted_interpretation": "Governed prospective candidate and next action; not a validated target or treatment rank.",
      "claim_ceiling": "no_measured_candidate_level_dmd_response_or_clinical_prediction"
    },
    {
      "candidate_id": "NMDVCELL:DMD:CANDIDATE:RNF8",
      "record_version": 2,
      "disease_id": "DMD",
      "label": "RNF8",
      "entity_type": "gene",
      "identifiers": {
        "approved_symbol": "RNF8",
        "hgnc_id": "HGNC:10071",
        "ensembl_gene_id": "ENSG00000112130",
        "ncbi_gene_id": 9025
      },
      "role": "prospective_candidate",
      "state": "PREDICTED",
      "qualifiers": [
        "HYPOTHESIS_TRIAGE",
        "NEXT_ACTION_QUEUE",
        "NO_MEASURED_DMD_CANDIDATE_RESPONSE"
      ],
      "establishment_basis": "Frozen v0.6 multisource evidence vector plus governed current action; no current numeric rank.",
      "dataset_accessions": [],
      "contrast": "candidate perturbation versus matched control in a DMD-relevant muscle model",
      "effect": {
        "estimate": null,
        "unit": null,
        "availability": "MISSING",
        "measured_dmd_candidate_response": false,
        "historical_source_context_rescue_score": "0.0393946134940323",
        "historical_context_warning": "The historical source-context score is not a DMD effect size, p-value or treatment probability."
      },
      "statistical_unit": "not yet observed for candidate-level DMD response",
      "provenance": {
        "current_record": "/resource/api/v1/candidates.json",
        "truth_boundary": "/resource/api/v1.6/measured-dmd-evidence/candidate-truth-boundary.json",
        "gap_code": "GAP-08",
        "highest_supported_level": "L2_observed_same_context_perturbation"
      },
      "next_experiment": "Resolve dependency, toxicity and context-risk flags before DMD perturbation.",
      "current_action": "risk_review",
      "permitted_interpretation": "Governed prospective candidate and next action; not a validated target or treatment rank.",
      "claim_ceiling": "no_measured_candidate_level_dmd_response_or_clinical_prediction"
    },
    {
      "candidate_id": "NMDVCELL:DMD:CANDIDATE:WDR4",
      "record_version": 2,
      "disease_id": "DMD",
      "label": "WDR4",
      "entity_type": "gene",
      "identifiers": {
        "approved_symbol": "WDR4",
        "hgnc_id": "HGNC:12756",
        "ensembl_gene_id": "ENSG00000160193",
        "ncbi_gene_id": 10785
      },
      "role": "prospective_candidate",
      "state": "PREDICTED",
      "qualifiers": [
        "HYPOTHESIS_TRIAGE",
        "NEXT_ACTION_QUEUE",
        "NO_MEASURED_DMD_CANDIDATE_RESPONSE"
      ],
      "establishment_basis": "Frozen v0.6 multisource evidence vector plus governed current action; no current numeric rank.",
      "dataset_accessions": [],
      "contrast": "candidate perturbation versus matched control in a DMD-relevant muscle model",
      "effect": {
        "estimate": null,
        "unit": null,
        "availability": "MISSING",
        "measured_dmd_candidate_response": false,
        "historical_source_context_rescue_score": "0.0185197163615708",
        "historical_context_warning": "The historical source-context score is not a DMD effect size, p-value or treatment probability."
      },
      "statistical_unit": "not yet observed for candidate-level DMD response",
      "provenance": {
        "current_record": "/resource/api/v1/candidates.json",
        "truth_boundary": "/resource/api/v1.6/measured-dmd-evidence/candidate-truth-boundary.json",
        "gap_code": "GAP-08",
        "highest_supported_level": "L2_observed_same_context_perturbation"
      },
      "next_experiment": "Resolve dependency, toxicity and context-risk flags before DMD perturbation.",
      "current_action": "risk_review",
      "permitted_interpretation": "Governed prospective candidate and next action; not a validated target or treatment rank.",
      "claim_ceiling": "no_measured_candidate_level_dmd_response_or_clinical_prediction"
    },
    {
      "candidate_id": "NMDVCELL:DMD:CANDIDATE:ZNF236",
      "record_version": 2,
      "disease_id": "DMD",
      "label": "ZNF236",
      "entity_type": "gene",
      "identifiers": {
        "approved_symbol": "ZNF236",
        "hgnc_id": "HGNC:13028",
        "ensembl_gene_id": "ENSG00000130856",
        "ncbi_gene_id": 7776
      },
      "role": "prospective_candidate",
      "state": "PREDICTED",
      "qualifiers": [
        "HYPOTHESIS_TRIAGE",
        "NEXT_ACTION_QUEUE",
        "NO_MEASURED_DMD_CANDIDATE_RESPONSE"
      ],
      "establishment_basis": "Frozen v0.6 multisource evidence vector plus governed current action; no current numeric rank.",
      "dataset_accessions": [],
      "contrast": "candidate perturbation versus matched control in a DMD-relevant muscle model",
      "effect": {
        "estimate": null,
        "unit": null,
        "availability": "MISSING",
        "measured_dmd_candidate_response": false,
        "historical_source_context_rescue_score": "0.0596269867166334",
        "historical_context_warning": "The historical source-context score is not a DMD effect size, p-value or treatment probability."
      },
      "statistical_unit": "not yet observed for candidate-level DMD response",
      "provenance": {
        "current_record": "/resource/api/v1/candidates.json",
        "truth_boundary": "/resource/api/v1.6/measured-dmd-evidence/candidate-truth-boundary.json",
        "gap_code": "GAP-08",
        "highest_supported_level": "L2_observed_same_context_perturbation"
      },
      "next_experiment": "Resolve dependency, toxicity and context-risk flags before DMD perturbation.",
      "current_action": "risk_review",
      "permitted_interpretation": "Governed prospective candidate and next action; not a validated target or treatment rank.",
      "claim_ceiling": "no_measured_candidate_level_dmd_response_or_clinical_prediction"
    },
    {
      "candidate_id": "NMDVCELL:DMD:CANDIDATE:MON1A",
      "record_version": 2,
      "disease_id": "DMD",
      "label": "MON1A",
      "entity_type": "gene",
      "identifiers": {
        "approved_symbol": "MON1A",
        "hgnc_id": "HGNC:28207",
        "ensembl_gene_id": "ENSG00000164077",
        "ncbi_gene_id": 84315
      },
      "role": "prospective_candidate",
      "state": "PREDICTED",
      "qualifiers": [
        "HYPOTHESIS_TRIAGE",
        "NEXT_ACTION_QUEUE",
        "NO_MEASURED_DMD_CANDIDATE_RESPONSE"
      ],
      "establishment_basis": "Frozen v0.6 multisource evidence vector plus governed current action; no current numeric rank.",
      "dataset_accessions": [],
      "contrast": "candidate perturbation versus matched control in a DMD-relevant muscle model",
      "effect": {
        "estimate": null,
        "unit": null,
        "availability": "MISSING",
        "measured_dmd_candidate_response": false,
        "historical_source_context_rescue_score": "0.0465108672448511",
        "historical_context_warning": "The historical source-context score is not a DMD effect size, p-value or treatment probability."
      },
      "statistical_unit": "not yet observed for candidate-level DMD response",
      "provenance": {
        "current_record": "/resource/api/v1/candidates.json",
        "truth_boundary": "/resource/api/v1.6/measured-dmd-evidence/candidate-truth-boundary.json",
        "gap_code": "GAP-02",
        "highest_supported_level": "L2_observed_same_context_perturbation"
      },
      "next_experiment": "Run a replicate-aware DMD muscle perturbation assay with prespecified molecular and functional endpoints.",
      "current_action": "muscle_assay",
      "permitted_interpretation": "Governed prospective candidate and next action; not a validated target or treatment rank.",
      "claim_ceiling": "no_measured_candidate_level_dmd_response_or_clinical_prediction"
    },
    {
      "candidate_id": "NMDVCELL:DMD:CANDIDATE:ZNF133",
      "record_version": 2,
      "disease_id": "DMD",
      "label": "ZNF133",
      "entity_type": "gene",
      "identifiers": {
        "approved_symbol": "ZNF133",
        "hgnc_id": "HGNC:12917",
        "ensembl_gene_id": "ENSG00000125846",
        "ncbi_gene_id": 7692
      },
      "role": "prospective_candidate",
      "state": "PREDICTED",
      "qualifiers": [
        "HYPOTHESIS_TRIAGE",
        "NEXT_ACTION_QUEUE",
        "NO_MEASURED_DMD_CANDIDATE_RESPONSE"
      ],
      "establishment_basis": "Frozen v0.6 multisource evidence vector plus governed current action; no current numeric rank.",
      "dataset_accessions": [],
      "contrast": "candidate perturbation versus matched control in a DMD-relevant muscle model",
      "effect": {
        "estimate": null,
        "unit": null,
        "availability": "MISSING",
        "measured_dmd_candidate_response": false,
        "historical_source_context_rescue_score": "0.0638177433316608",
        "historical_context_warning": "The historical source-context score is not a DMD effect size, p-value or treatment probability."
      },
      "statistical_unit": "not yet observed for candidate-level DMD response",
      "provenance": {
        "current_record": "/resource/api/v1/candidates.json",
        "truth_boundary": "/resource/api/v1.6/measured-dmd-evidence/candidate-truth-boundary.json",
        "gap_code": "GAP-02",
        "highest_supported_level": "L2_observed_same_context_perturbation"
      },
      "next_experiment": "Run a replicate-aware DMD muscle perturbation assay with prespecified molecular and functional endpoints.",
      "current_action": "muscle_assay",
      "permitted_interpretation": "Governed prospective candidate and next action; not a validated target or treatment rank.",
      "claim_ceiling": "no_measured_candidate_level_dmd_response_or_clinical_prediction"
    },
    {
      "candidate_id": "NMDVCELL:DMD:CANDIDATE:ADAM10",
      "record_version": 2,
      "disease_id": "DMD",
      "label": "ADAM10",
      "entity_type": "gene",
      "identifiers": {
        "approved_symbol": "ADAM10",
        "hgnc_id": "HGNC:188",
        "ensembl_gene_id": "ENSG00000137845",
        "ncbi_gene_id": 102
      },
      "role": "prospective_candidate",
      "state": "PREDICTED",
      "qualifiers": [
        "HYPOTHESIS_TRIAGE",
        "NEXT_ACTION_QUEUE",
        "NO_MEASURED_DMD_CANDIDATE_RESPONSE"
      ],
      "establishment_basis": "Frozen v0.6 multisource evidence vector plus governed current action; no current numeric rank.",
      "dataset_accessions": [],
      "contrast": "candidate perturbation versus matched control in a DMD-relevant muscle model",
      "effect": {
        "estimate": null,
        "unit": null,
        "availability": "MISSING",
        "measured_dmd_candidate_response": false,
        "historical_source_context_rescue_score": "0.016577908426075",
        "historical_context_warning": "The historical source-context score is not a DMD effect size, p-value or treatment probability."
      },
      "statistical_unit": "not yet observed for candidate-level DMD response",
      "provenance": {
        "current_record": "/resource/api/v1/candidates.json",
        "truth_boundary": "/resource/api/v1.6/measured-dmd-evidence/candidate-truth-boundary.json",
        "gap_code": "GAP-07",
        "highest_supported_level": "L2_observed_same_context_perturbation"
      },
      "next_experiment": "Replicate the source-context signal in a frozen independent computational audit before wet-lab escalation.",
      "current_action": "computational_replication",
      "permitted_interpretation": "Governed prospective candidate and next action; not a validated target or treatment rank.",
      "claim_ceiling": "no_measured_candidate_level_dmd_response_or_clinical_prediction"
    },
    {
      "candidate_id": "NMDVCELL:DMD:CANDIDATE:CALR",
      "record_version": 2,
      "disease_id": "DMD",
      "label": "CALR",
      "entity_type": "gene",
      "identifiers": {
        "approved_symbol": "CALR",
        "hgnc_id": "HGNC:1455",
        "ensembl_gene_id": "ENSG00000179218",
        "ncbi_gene_id": 811
      },
      "role": "prospective_candidate",
      "state": "PREDICTED",
      "qualifiers": [
        "HYPOTHESIS_TRIAGE",
        "NEXT_ACTION_QUEUE",
        "NO_MEASURED_DMD_CANDIDATE_RESPONSE"
      ],
      "establishment_basis": "Frozen v0.6 multisource evidence vector plus governed current action; no current numeric rank.",
      "dataset_accessions": [],
      "contrast": "candidate perturbation versus matched control in a DMD-relevant muscle model",
      "effect": {
        "estimate": null,
        "unit": null,
        "availability": "MISSING",
        "measured_dmd_candidate_response": false,
        "historical_source_context_rescue_score": "0.0342720008433927",
        "historical_context_warning": "The historical source-context score is not a DMD effect size, p-value or treatment probability."
      },
      "statistical_unit": "not yet observed for candidate-level DMD response",
      "provenance": {
        "current_record": "/resource/api/v1/candidates.json",
        "truth_boundary": "/resource/api/v1.6/measured-dmd-evidence/candidate-truth-boundary.json",
        "gap_code": "GAP-07",
        "highest_supported_level": "L2_observed_same_context_perturbation"
      },
      "next_experiment": "Replicate the source-context signal in a frozen independent computational audit before wet-lab escalation.",
      "current_action": "computational_replication",
      "permitted_interpretation": "Governed prospective candidate and next action; not a validated target or treatment rank.",
      "claim_ceiling": "no_measured_candidate_level_dmd_response_or_clinical_prediction"
    },
    {
      "candidate_id": "NMDVCELL:DMD:CANDIDATE:DDX19B",
      "record_version": 2,
      "disease_id": "DMD",
      "label": "DDX19B",
      "entity_type": "gene",
      "identifiers": {
        "approved_symbol": "DDX19B",
        "hgnc_id": "HGNC:2742",
        "ensembl_gene_id": "ENSG00000157349",
        "ncbi_gene_id": 11269
      },
      "role": "prospective_candidate",
      "state": "PREDICTED",
      "qualifiers": [
        "HYPOTHESIS_TRIAGE",
        "NEXT_ACTION_QUEUE",
        "NO_MEASURED_DMD_CANDIDATE_RESPONSE"
      ],
      "establishment_basis": "Frozen v0.6 multisource evidence vector plus governed current action; no current numeric rank.",
      "dataset_accessions": [],
      "contrast": "candidate perturbation versus matched control in a DMD-relevant muscle model",
      "effect": {
        "estimate": null,
        "unit": null,
        "availability": "MISSING",
        "measured_dmd_candidate_response": false,
        "historical_source_context_rescue_score": "0.0181322540721587",
        "historical_context_warning": "The historical source-context score is not a DMD effect size, p-value or treatment probability."
      },
      "statistical_unit": "not yet observed for candidate-level DMD response",
      "provenance": {
        "current_record": "/resource/api/v1/candidates.json",
        "truth_boundary": "/resource/api/v1.6/measured-dmd-evidence/candidate-truth-boundary.json",
        "gap_code": "GAP-07",
        "highest_supported_level": "L2_observed_same_context_perturbation"
      },
      "next_experiment": "Replicate the source-context signal in a frozen independent computational audit before wet-lab escalation.",
      "current_action": "computational_replication",
      "permitted_interpretation": "Governed prospective candidate and next action; not a validated target or treatment rank.",
      "claim_ceiling": "no_measured_candidate_level_dmd_response_or_clinical_prediction"
    },
    {
      "candidate_id": "NMDVCELL:DMD:CANDIDATE:DNM1",
      "record_version": 2,
      "disease_id": "DMD",
      "label": "DNM1",
      "entity_type": "gene",
      "identifiers": {
        "approved_symbol": "DNM1",
        "hgnc_id": "HGNC:2972",
        "ensembl_gene_id": "ENSG00000106976",
        "ncbi_gene_id": 1759
      },
      "role": "prospective_candidate",
      "state": "PREDICTED",
      "qualifiers": [
        "HYPOTHESIS_TRIAGE",
        "NEXT_ACTION_QUEUE",
        "NO_MEASURED_DMD_CANDIDATE_RESPONSE"
      ],
      "establishment_basis": "Frozen v0.6 multisource evidence vector plus governed current action; no current numeric rank.",
      "dataset_accessions": [],
      "contrast": "candidate perturbation versus matched control in a DMD-relevant muscle model",
      "effect": {
        "estimate": null,
        "unit": null,
        "availability": "MISSING",
        "measured_dmd_candidate_response": false,
        "historical_source_context_rescue_score": "0.0023798166472955",
        "historical_context_warning": "The historical source-context score is not a DMD effect size, p-value or treatment probability."
      },
      "statistical_unit": "not yet observed for candidate-level DMD response",
      "provenance": {
        "current_record": "/resource/api/v1/candidates.json",
        "truth_boundary": "/resource/api/v1.6/measured-dmd-evidence/candidate-truth-boundary.json",
        "gap_code": "GAP-07",
        "highest_supported_level": "L2_observed_same_context_perturbation"
      },
      "next_experiment": "Replicate the source-context signal in a frozen independent computational audit before wet-lab escalation.",
      "current_action": "computational_replication",
      "permitted_interpretation": "Governed prospective candidate and next action; not a validated target or treatment rank.",
      "claim_ceiling": "no_measured_candidate_level_dmd_response_or_clinical_prediction"
    },
    {
      "candidate_id": "NMDVCELL:DMD:CANDIDATE:EHMT2",
      "record_version": 2,
      "disease_id": "DMD",
      "label": "EHMT2",
      "entity_type": "gene",
      "identifiers": {
        "approved_symbol": "EHMT2",
        "hgnc_id": "HGNC:14129",
        "ensembl_gene_id": "ENSG00000204371",
        "ncbi_gene_id": 10919
      },
      "role": "prospective_candidate",
      "state": "PREDICTED",
      "qualifiers": [
        "HYPOTHESIS_TRIAGE",
        "NEXT_ACTION_QUEUE",
        "NO_MEASURED_DMD_CANDIDATE_RESPONSE"
      ],
      "establishment_basis": "Frozen v0.6 multisource evidence vector plus governed current action; no current numeric rank.",
      "dataset_accessions": [],
      "contrast": "candidate perturbation versus matched control in a DMD-relevant muscle model",
      "effect": {
        "estimate": null,
        "unit": null,
        "availability": "MISSING",
        "measured_dmd_candidate_response": false,
        "historical_source_context_rescue_score": "0.0298003663560908",
        "historical_context_warning": "The historical source-context score is not a DMD effect size, p-value or treatment probability."
      },
      "statistical_unit": "not yet observed for candidate-level DMD response",
      "provenance": {
        "current_record": "/resource/api/v1/candidates.json",
        "truth_boundary": "/resource/api/v1.6/measured-dmd-evidence/candidate-truth-boundary.json",
        "gap_code": "GAP-07",
        "highest_supported_level": "L2_observed_same_context_perturbation"
      },
      "next_experiment": "Replicate the source-context signal in a frozen independent computational audit before wet-lab escalation.",
      "current_action": "computational_replication",
      "permitted_interpretation": "Governed prospective candidate and next action; not a validated target or treatment rank.",
      "claim_ceiling": "no_measured_candidate_level_dmd_response_or_clinical_prediction"
    },
    {
      "candidate_id": "NMDVCELL:DMD:CANDIDATE:LMO2",
      "record_version": 2,
      "disease_id": "DMD",
      "label": "LMO2",
      "entity_type": "gene",
      "identifiers": {
        "approved_symbol": "LMO2",
        "hgnc_id": "HGNC:6642",
        "ensembl_gene_id": "ENSG00000135363",
        "ncbi_gene_id": 4005
      },
      "role": "prospective_candidate",
      "state": "PREDICTED",
      "qualifiers": [
        "HYPOTHESIS_TRIAGE",
        "NEXT_ACTION_QUEUE",
        "NO_MEASURED_DMD_CANDIDATE_RESPONSE"
      ],
      "establishment_basis": "Frozen v0.6 multisource evidence vector plus governed current action; no current numeric rank.",
      "dataset_accessions": [],
      "contrast": "candidate perturbation versus matched control in a DMD-relevant muscle model",
      "effect": {
        "estimate": null,
        "unit": null,
        "availability": "MISSING",
        "measured_dmd_candidate_response": false,
        "historical_source_context_rescue_score": "0.0072367047585843",
        "historical_context_warning": "The historical source-context score is not a DMD effect size, p-value or treatment probability."
      },
      "statistical_unit": "not yet observed for candidate-level DMD response",
      "provenance": {
        "current_record": "/resource/api/v1/candidates.json",
        "truth_boundary": "/resource/api/v1.6/measured-dmd-evidence/candidate-truth-boundary.json",
        "gap_code": "GAP-07",
        "highest_supported_level": "L2_observed_same_context_perturbation"
      },
      "next_experiment": "Replicate the source-context signal in a frozen independent computational audit before wet-lab escalation.",
      "current_action": "computational_replication",
      "permitted_interpretation": "Governed prospective candidate and next action; not a validated target or treatment rank.",
      "claim_ceiling": "no_measured_candidate_level_dmd_response_or_clinical_prediction"
    },
    {
      "candidate_id": "NMDVCELL:DMD:CANDIDATE:MPHOSPH6",
      "record_version": 2,
      "disease_id": "DMD",
      "label": "MPHOSPH6",
      "entity_type": "gene",
      "identifiers": {
        "approved_symbol": "MPHOSPH6",
        "hgnc_id": "HGNC:7214",
        "ensembl_gene_id": "ENSG00000135698",
        "ncbi_gene_id": 10200
      },
      "role": "prospective_candidate",
      "state": "PREDICTED",
      "qualifiers": [
        "HYPOTHESIS_TRIAGE",
        "NEXT_ACTION_QUEUE",
        "NO_MEASURED_DMD_CANDIDATE_RESPONSE"
      ],
      "establishment_basis": "Frozen v0.6 multisource evidence vector plus governed current action; no current numeric rank.",
      "dataset_accessions": [],
      "contrast": "candidate perturbation versus matched control in a DMD-relevant muscle model",
      "effect": {
        "estimate": null,
        "unit": null,
        "availability": "MISSING",
        "measured_dmd_candidate_response": false,
        "historical_source_context_rescue_score": "0.0156264944854757",
        "historical_context_warning": "The historical source-context score is not a DMD effect size, p-value or treatment probability."
      },
      "statistical_unit": "not yet observed for candidate-level DMD response",
      "provenance": {
        "current_record": "/resource/api/v1/candidates.json",
        "truth_boundary": "/resource/api/v1.6/measured-dmd-evidence/candidate-truth-boundary.json",
        "gap_code": "GAP-07",
        "highest_supported_level": "L2_observed_same_context_perturbation"
      },
      "next_experiment": "Replicate the source-context signal in a frozen independent computational audit before wet-lab escalation.",
      "current_action": "computational_replication",
      "permitted_interpretation": "Governed prospective candidate and next action; not a validated target or treatment rank.",
      "claim_ceiling": "no_measured_candidate_level_dmd_response_or_clinical_prediction"
    },
    {
      "candidate_id": "NMDVCELL:DMD:CANDIDATE:GFOD2",
      "record_version": 2,
      "disease_id": "DMD",
      "label": "GFOD2",
      "entity_type": "gene",
      "identifiers": {
        "approved_symbol": "GFOD2",
        "hgnc_id": "HGNC:28159",
        "ensembl_gene_id": "ENSG00000141098",
        "ncbi_gene_id": 81577
      },
      "role": "prospective_candidate",
      "state": "PREDICTED",
      "qualifiers": [
        "HYPOTHESIS_TRIAGE",
        "NEXT_ACTION_QUEUE",
        "NO_MEASURED_DMD_CANDIDATE_RESPONSE"
      ],
      "establishment_basis": "Frozen v0.6 multisource evidence vector plus governed current action; no current numeric rank.",
      "dataset_accessions": [],
      "contrast": "candidate perturbation versus matched control in a DMD-relevant muscle model",
      "effect": {
        "estimate": null,
        "unit": null,
        "availability": "MISSING",
        "measured_dmd_candidate_response": false,
        "historical_source_context_rescue_score": "0.0741134084110689",
        "historical_context_warning": "The historical source-context score is not a DMD effect size, p-value or treatment probability."
      },
      "statistical_unit": "not yet observed for candidate-level DMD response",
      "provenance": {
        "current_record": "/resource/api/v1/candidates.json",
        "truth_boundary": "/resource/api/v1.6/measured-dmd-evidence/candidate-truth-boundary.json",
        "gap_code": "GAP-09",
        "highest_supported_level": "L2_observed_same_context_perturbation"
      },
      "next_experiment": "Hold the candidate until the named external evidence audit is complete.",
      "current_action": "hold_pending_external_audit",
      "permitted_interpretation": "Governed prospective candidate and next action; not a validated target or treatment rank.",
      "claim_ceiling": "no_measured_candidate_level_dmd_response_or_clinical_prediction"
    }
  ]
}
