{
  "disease": "DM1",
  "records": [
    {
      "disease": "DM1",
      "candidate_or_module": "DMPK",
      "role": "etiologic_anchor",
      "establishment_basis": "CTG_repeat_excision_isogenic_design",
      "evidence_state": "CORRECTED",
      "permitted_interpretation": "Etiologic RNA-toxicity anchor"
    },
    {
      "disease": "DM1",
      "candidate_or_module": "MBNL1",
      "role": "splicing_regulator",
      "establishment_basis": "repeat_correction_plus_patient_splicing_context",
      "evidence_state": "CORRECTED+MEASURED",
      "permitted_interpretation": "Mechanism anchor; not a clinical rank"
    },
    {
      "disease": "DM1",
      "candidate_or_module": "MBNL2",
      "role": "splicing_regulator",
      "establishment_basis": "repeat_correction_plus_patient_splicing_context",
      "evidence_state": "CORRECTED+MEASURED",
      "permitted_interpretation": "Mechanism anchor; not a clinical rank"
    },
    {
      "disease": "DM1",
      "candidate_or_module": "CLCN1",
      "role": "functional_endpoint",
      "establishment_basis": "patient_exon_skipping",
      "evidence_state": "MEASURED",
      "permitted_interpretation": "Functional splicing endpoint"
    },
    {
      "disease": "DM1",
      "candidate_or_module": "BIN1",
      "role": "functional_endpoint",
      "establishment_basis": "patient_exon_skipping",
      "evidence_state": "MEASURED",
      "permitted_interpretation": "Functional splicing endpoint"
    },
    {
      "disease": "DM1",
      "candidate_or_module": "INSR",
      "role": "functional_endpoint",
      "establishment_basis": "patient_exon_skipping",
      "evidence_state": "MEASURED",
      "permitted_interpretation": "Functional splicing endpoint"
    }
  ]
}