[
  {
    "coverage": "21/21",
    "evidence_layer": "Observed HepG2 candidate perturbation",
    "evidence_level": "L2",
    "supported_use": "Bounded same-HepG2 hypothesis triage",
    "unsupported_inference": "Muscle or DMD target validation"
  },
  {
    "coverage": "9/21",
    "evidence_layer": "Human-myoblast fusion phenotype",
    "evidence_level": "L3 context stress test",
    "supported_use": "Coverage-aware risk/exclusion review",
    "unsupported_inference": "Safety, efficacy or negative status for unassessed genes"
  },
  {
    "coverage": "0/21",
    "evidence_layer": "Independent muscle/DMD perturbation transcriptome",
    "evidence_level": "L4 unsupported",
    "supported_use": "Evidence-gap declaration",
    "unsupported_inference": "Disease-relevant perturbation validity"
  },
  {
    "coverage": "0 validated endpoints",
    "evidence_layer": "Therapeutic or clinical utility",
    "evidence_level": "L5 unsupported",
    "supported_use": "None in this release",
    "unsupported_inference": "Treatment benefit or clinical recommendation"
  }
]