{
  "schema": "nmd-vcell-candidate-dmd-statistical-bridge-api/1.0",
  "object_id": "CDB:PCB-v0.2-20260804:EA-20260817-57",
  "analysis_id": "PCB-v0.2-20260804",
  "resource_release": "v1.2.0-measured-dmd-evidence",
  "interface_build": "EA-20260817-57",
  "evidence_freeze": "2026-08-03",
  "release_state": "RELEASED_SOURCE_CONTEXT_STATISTICAL_BRIDGE_PROSPECTIVE_VALIDATION_PRESPECIFIED",
  "headline_results": {
    "candidate_count": 21,
    "measured_hepg2_candidate_perturbations": 21,
    "reactome_camera_rows": 28938,
    "camera_supported_candidate_pathway_pairs": 1830,
    "split_half_robust_candidate_pathway_pairs": 1782,
    "projected_reversal_rows": 3210,
    "prospective_priority_count": 3
  },
  "validation_status": {
    "section": "limitations",
    "stage": "prospective_validation_prespecified",
    "candidate_count": 21,
    "measured_dmd_candidate_perturbations": 0,
    "measured_fraction": "0/21",
    "validated_candidate_level_dmd_pathway_predictions": 0,
    "interpretation": "Validation gap; not an observed negative biological effect.",
    "prospective_panel": "/resource/downloads/prospective_dmd_perturb_seq_panel_v01.tsv"
  },
  "evidence_chain": [
    "measured HepG2 candidate response",
    "Reactome competitive test",
    "cross-context DMD pathway projection",
    "exploratory source heterogeneity",
    "prespecified prospective DMD validation study"
  ],
  "api": {
    "candidate_summary": "candidate-summary.json",
    "projection_heterogeneity": "projection-heterogeneity.json",
    "source_context_audit": "source-context-audit.json",
    "statistical_contract": "statistical-contract.json",
    "release_manifest": "release-manifest.json"
  },
  "figure": {
    "page": "/resource/cascade-network/#candidate-statistical-bridge",
    "svg": "/resource/assets/figure6_candidate_dmd_statistical_bridge.svg",
    "pdf": "/resource/downloads/figure6_candidate_dmd_statistical_bridge_v2.pdf",
    "png": "/resource/downloads/figure6_candidate_dmd_statistical_bridge_v2.png"
  },
  "large_table_hosting": {
    "policy": "source_release_ro_crate_only_not_directly_hosted",
    "files": [
      "candidate_cross_context_dmd_pathway_reversal_v2.tsv.gz",
      "candidate_hepg2_cell_level_de_v2.tsv.gz",
      "candidate_reactome_camera_pr_v2.tsv.gz"
    ],
    "portable_manifest": "/resource/api/v1.1/portable_release_bundle.json",
    "directly_hosted_compact_objects": [
      "candidate-summary.json",
      "projection-heterogeneity.json",
      "source-context-audit.json",
      "candidate_dmd_bridge_summary_v2.tsv",
      "candidate_dmd_projection_heterogeneity_v2.tsv"
    ]
  },
  "claim_boundary": {
    "allowed": "Measured HepG2 candidate responses, exploratory source-context competitive tests and explicit cross-DMD-source projections.",
    "blocked": "Measured candidate response in DMD muscle, validated candidate-level DMD pathway prediction, therapeutic rescue or clinical recommendation.",
    "validation_reporting": "Exact experimental validation status is reported under validation_status and in the release manifest."
  }
}