{
  "schema": "nmd-vcell-candidate-dmd-statistical-contract/1.0",
  "analysis_id": "PCB-v0.2-20260804",
  "resource_release": "v1.2.0-measured-dmd-evidence",
  "interface_build": "EA-20260817-57",
  "candidate_differential_expression": {
    "method": "Welch cell-level exploratory statistics on normalized HepG2 expression",
    "inferential_unit": "cell",
    "biological_replicate_column_available": false,
    "allowed_interpretation": "source-context response ranking",
    "blocked_interpretation": "donor-level or disease-level inference"
  },
  "reactome_competition": {
    "method": "limma cameraPR",
    "inter_gene_correlation": 0.01,
    "multiplicity": "Benjamini-Hochberg within candidate",
    "robustness_gate": "FDR < 0.05 and concordant direct, split-A and split-B direction"
  },
  "dmd_projection": {
    "sources": [
      "GSE233606",
      "GSE272233",
      "GSE277637"
    ],
    "method": "directional projection onto separately measured DMD source axes",
    "evidence_state": "CROSS_CONTEXT_DMD_REVERSAL_PROJECTION_NOT_DMD_CANDIDATE_MEASUREMENT"
  },
  "heterogeneity": {
    "method": "Fisher-z summary, Cochran Q and I2",
    "interpretation": "descriptive stress test",
    "limitation": "Reactome pathways overlap and the three source vectors are not independent studies"
  }
}