{
  "schema": "nmd-vcell-candidate-dmd-bridge-candidate-summary/1.0",
  "analysis_id": "PCB-v0.2-20260804",
  "resource_release": "v1.2.0-measured-dmd-evidence",
  "record_count": 21,
  "records": [
    {
      "candidate": "CPEB1",
      "candidate_cells": 100,
      "control_cells": 4976,
      "target_gene_in_expression_panel": false,
      "target_gene_delta": null,
      "cell_level_fdr_lt_0_05": 1379,
      "cell_level_fdr_lt_0_05_abs_delta_ge_0_1": 1024,
      "inferential_unit": "cell_exploratory_no_biological_replicate_column",
      "reactome_pathways_tested": 1378,
      "camera_fdr_lt_0_05": 381,
      "robust_camera_pathways": 376,
      "robust_camera_pathways_up": 100,
      "robust_camera_pathways_down": 276,
      "camera_supported_pathways_gse233606": 376,
      "camera_supported_pathways_gse272233": 376,
      "camera_supported_pathways_gse277637": 376,
      "projected_reversal_pathways_gse233606": 254,
      "projected_reversal_pathways_gse272233": 279,
      "projected_reversal_pathways_gse277637": 194,
      "k_sources": 3,
      "pooled_rescue_spearman": 0.16204450837865386,
      "pooled_se_fisher_z": 0.015750473013495386,
      "cochran_q": 165.04027797979188,
      "heterogeneity_pvalue": 1.4519745052630994e-36,
      "i2_percent": 98.7881746053258,
      "source_direction_consistent": false,
      "rescue_spearman_gse233606": 0.18987482864587504,
      "n_pathways_gse233606": 1360,
      "rescue_spearman_gse277637": -0.0943014465703711,
      "n_pathways_gse277637": 1360,
      "rescue_spearman_gse272233": 0.3797759138923687,
      "n_pathways_gse272233": 1320,
      "correction_alignment_spearman": 0.29989968512865267,
      "correction_alignment_n_pathways": 1320,
      "heterogeneity_boundary": "pathways_and_sources_are_not_independent_exploratory_fisher_z_Q_I2",
      "cascade_k_sources": 3,
      "cascade_pooled_rescue_spearman": 0.1138689170557922,
      "cascade_pooled_se_fisher_z": 0.015750473013495386,
      "cascade_cochran_q": 128.85436879037474,
      "cascade_heterogeneity_pvalue": 1.0462352122232484e-28,
      "cascade_i2_percent": 98.44786015501448,
      "cascade_source_direction_consistent": false,
      "cascade_rescue_spearman_gse233606": 0.15650668020207417,
      "cascade_n_pathways_gse233606": 1360,
      "cascade_rescue_spearman_gse277637": -0.120091038151028,
      "cascade_n_pathways_gse277637": 1360,
      "cascade_rescue_spearman_gse272233": 0.30205903292909925,
      "cascade_n_pathways_gse272233": 1320,
      "cascade_correction_alignment_spearman": 0.19998275391595444,
      "cascade_correction_alignment_n_pathways": 1320,
      "cascade_heterogeneity_boundary": "pathways_and_sources_are_not_independent_exploratory_fisher_z_Q_I2",
      "decision_state": "ABSTAIN_OR_VALIDATE_IN_DMD_PERTURB_SEQ",
      "abstention_reasons": "skeletal_muscle_tpm_le_1;target_engagement_coordinate_missing_or_not_suppressed",
      "claim_level": "L2_CROSS_CONTEXT_NETWORK_HYPOTHESIS_ONLY",
      "measured_candidate_dmd_perturbation": 0,
      "candidate_level_validated_dmd_pathway_prediction": 0,
      "current_claim": "source_context_effect_and_cross_context_projection_only"
    },
    {
      "candidate": "DNAAF3",
      "candidate_cells": 115,
      "control_cells": 4976,
      "target_gene_in_expression_panel": false,
      "target_gene_delta": null,
      "cell_level_fdr_lt_0_05": 11,
      "cell_level_fdr_lt_0_05_abs_delta_ge_0_1": 4,
      "inferential_unit": "cell_exploratory_no_biological_replicate_column",
      "reactome_pathways_tested": 1378,
      "camera_fdr_lt_0_05": 24,
      "robust_camera_pathways": 24,
      "robust_camera_pathways_up": 0,
      "robust_camera_pathways_down": 24,
      "camera_supported_pathways_gse233606": 24,
      "camera_supported_pathways_gse272233": 24,
      "camera_supported_pathways_gse277637": 24,
      "projected_reversal_pathways_gse233606": 1,
      "projected_reversal_pathways_gse272233": 23,
      "projected_reversal_pathways_gse277637": 24,
      "k_sources": 3,
      "pooled_rescue_spearman": -0.028593439506308216,
      "pooled_se_fisher_z": 0.015750473013495386,
      "cochran_q": 65.78569242505773,
      "heterogeneity_pvalue": 5.185831433185701e-15,
      "i2_percent": 96.95982526553418,
      "source_direction_consistent": false,
      "rescue_spearman_gse233606": -0.2048951163593469,
      "n_pathways_gse233606": 1360,
      "rescue_spearman_gse277637": 0.0672361300563732,
      "n_pathways_gse277637": 1360,
      "rescue_spearman_gse272233": 0.05716295946058126,
      "n_pathways_gse272233": 1320,
      "correction_alignment_spearman": 0.0247297173190242,
      "correction_alignment_n_pathways": 1320,
      "heterogeneity_boundary": "pathways_and_sources_are_not_independent_exploratory_fisher_z_Q_I2",
      "cascade_k_sources": 3,
      "cascade_pooled_rescue_spearman": 0.02573724382157259,
      "cascade_pooled_se_fisher_z": 0.015750473013495386,
      "cascade_cochran_q": 66.31838249912576,
      "cascade_heterogeneity_pvalue": 3.973252963064268e-15,
      "cascade_i2_percent": 96.98424490370168,
      "cascade_source_direction_consistent": false,
      "cascade_rescue_spearman_gse233606": -0.14661310419091464,
      "cascade_n_pathways_gse233606": 1360,
      "cascade_rescue_spearman_gse277637": 0.15423241720487313,
      "cascade_n_pathways_gse277637": 1360,
      "cascade_rescue_spearman_gse272233": 0.07064213472935335,
      "cascade_n_pathways_gse272233": 1320,
      "cascade_correction_alignment_spearman": -0.09354290417186115,
      "cascade_correction_alignment_n_pathways": 1320,
      "cascade_heterogeneity_boundary": "pathways_and_sources_are_not_independent_exploratory_fisher_z_Q_I2",
      "decision_state": "ABSTAIN_OR_VALIDATE_IN_DMD_PERTURB_SEQ",
      "abstention_reasons": "weak_split_half_measurement;skeletal_muscle_tpm_le_1;correction_alignment_not_positive;target_engagement_coordinate_missing_or_not_suppressed",
      "claim_level": "L2_CROSS_CONTEXT_NETWORK_HYPOTHESIS_ONLY",
      "measured_candidate_dmd_perturbation": 0,
      "candidate_level_validated_dmd_pathway_prediction": 0,
      "current_claim": "source_context_effect_and_cross_context_projection_only"
    },
    {
      "candidate": "EPS8L1",
      "candidate_cells": 269,
      "control_cells": 4976,
      "target_gene_in_expression_panel": false,
      "target_gene_delta": null,
      "cell_level_fdr_lt_0_05": 7,
      "cell_level_fdr_lt_0_05_abs_delta_ge_0_1": 1,
      "inferential_unit": "cell_exploratory_no_biological_replicate_column",
      "reactome_pathways_tested": 1378,
      "camera_fdr_lt_0_05": 28,
      "robust_camera_pathways": 28,
      "robust_camera_pathways_up": 6,
      "robust_camera_pathways_down": 22,
      "camera_supported_pathways_gse233606": 28,
      "camera_supported_pathways_gse272233": 28,
      "camera_supported_pathways_gse277637": 28,
      "projected_reversal_pathways_gse233606": 5,
      "projected_reversal_pathways_gse272233": 26,
      "projected_reversal_pathways_gse277637": 23,
      "k_sources": 3,
      "pooled_rescue_spearman": 0.21734361951839049,
      "pooled_se_fisher_z": 0.015750473013495386,
      "cochran_q": 60.868597543079375,
      "heterogeneity_pvalue": 6.061107446771077e-14,
      "i2_percent": 96.71423347879092,
      "source_direction_consistent": true,
      "rescue_spearman_gse233606": 0.28065232865446793,
      "n_pathways_gse233606": 1360,
      "rescue_spearman_gse277637": 0.04978503247844803,
      "n_pathways_gse277637": 1360,
      "rescue_spearman_gse272233": 0.31629668198234706,
      "n_pathways_gse272233": 1320,
      "correction_alignment_spearman": 0.12992134012275297,
      "correction_alignment_n_pathways": 1320,
      "heterogeneity_boundary": "pathways_and_sources_are_not_independent_exploratory_fisher_z_Q_I2",
      "cascade_k_sources": 3,
      "cascade_pooled_rescue_spearman": 0.19483276706427208,
      "cascade_pooled_se_fisher_z": 0.015750473013495386,
      "cascade_cochran_q": 83.35594209839599,
      "cascade_heterogeneity_pvalue": 7.933907931198721e-19,
      "cascade_i2_percent": 97.60065095582611,
      "cascade_source_direction_consistent": false,
      "cascade_rescue_spearman_gse233606": 0.286910914000394,
      "cascade_n_pathways_gse233606": 1360,
      "cascade_rescue_spearman_gse277637": -0.004435821941054839,
      "cascade_n_pathways_gse277637": 1360,
      "cascade_rescue_spearman_gse272233": 0.2953919926214207,
      "cascade_n_pathways_gse272233": 1320,
      "cascade_correction_alignment_spearman": 0.12917653531432213,
      "cascade_correction_alignment_n_pathways": 1320,
      "cascade_heterogeneity_boundary": "pathways_and_sources_are_not_independent_exploratory_fisher_z_Q_I2",
      "decision_state": "ABSTAIN_OR_VALIDATE_IN_DMD_PERTURB_SEQ",
      "abstention_reasons": "skeletal_muscle_tpm_le_1;target_engagement_coordinate_missing_or_not_suppressed",
      "claim_level": "L2_CROSS_CONTEXT_NETWORK_HYPOTHESIS_ONLY",
      "measured_candidate_dmd_perturbation": 0,
      "candidate_level_validated_dmd_pathway_prediction": 0,
      "current_claim": "source_context_effect_and_cross_context_projection_only"
    },
    {
      "candidate": "ZFP69B",
      "candidate_cells": 81,
      "control_cells": 4976,
      "target_gene_in_expression_panel": false,
      "target_gene_delta": null,
      "cell_level_fdr_lt_0_05": 10,
      "cell_level_fdr_lt_0_05_abs_delta_ge_0_1": 1,
      "inferential_unit": "cell_exploratory_no_biological_replicate_column",
      "reactome_pathways_tested": 1378,
      "camera_fdr_lt_0_05": 0,
      "robust_camera_pathways": 0,
      "robust_camera_pathways_up": 0,
      "robust_camera_pathways_down": 0,
      "camera_supported_pathways_gse233606": 0,
      "camera_supported_pathways_gse272233": 0,
      "camera_supported_pathways_gse277637": 0,
      "projected_reversal_pathways_gse233606": 0,
      "projected_reversal_pathways_gse272233": 0,
      "projected_reversal_pathways_gse277637": 0,
      "k_sources": 3,
      "pooled_rescue_spearman": 0.10406364386111017,
      "pooled_se_fisher_z": 0.015750473013495386,
      "cochran_q": 35.68800594744478,
      "heterogeneity_pvalue": 1.7801146462401558e-08,
      "i2_percent": 94.39587629820153,
      "source_direction_consistent": true,
      "rescue_spearman_gse233606": 0.015276986604846993,
      "n_pathways_gse233606": 1360,
      "rescue_spearman_gse277637": 0.22949455974215227,
      "n_pathways_gse277637": 1360,
      "rescue_spearman_gse272233": 0.06309087731627631,
      "n_pathways_gse272233": 1320,
      "correction_alignment_spearman": -0.14494139693388536,
      "correction_alignment_n_pathways": 1320,
      "heterogeneity_boundary": "pathways_and_sources_are_not_independent_exploratory_fisher_z_Q_I2",
      "cascade_k_sources": 3,
      "cascade_pooled_rescue_spearman": 0.10746049507282801,
      "cascade_pooled_se_fisher_z": 0.015750473013495386,
      "cascade_cochran_q": 32.39615728061815,
      "cascade_heterogeneity_pvalue": 9.231320493285751e-08,
      "cascade_i2_percent": 93.82642829309712,
      "cascade_source_direction_consistent": false,
      "cascade_rescue_spearman_gse233606": -0.01328340336322973,
      "cascade_n_pathways_gse233606": 1360,
      "cascade_rescue_spearman_gse277637": 0.13915131906557054,
      "cascade_n_pathways_gse277637": 1360,
      "cascade_rescue_spearman_gse272233": 0.19695019976099384,
      "cascade_n_pathways_gse272233": 1320,
      "cascade_correction_alignment_spearman": -0.05739240042925521,
      "cascade_correction_alignment_n_pathways": 1320,
      "cascade_heterogeneity_boundary": "pathways_and_sources_are_not_independent_exploratory_fisher_z_Q_I2",
      "decision_state": "ABSTAIN_OR_VALIDATE_IN_DMD_PERTURB_SEQ",
      "abstention_reasons": "weak_split_half_measurement;skeletal_muscle_tpm_le_1;correction_alignment_not_positive;target_engagement_coordinate_missing_or_not_suppressed",
      "claim_level": "L2_CROSS_CONTEXT_NETWORK_HYPOTHESIS_ONLY",
      "measured_candidate_dmd_perturbation": 0,
      "candidate_level_validated_dmd_pathway_prediction": 0,
      "current_claim": "source_context_effect_and_cross_context_projection_only"
    },
    {
      "candidate": "INTS13",
      "candidate_cells": 157,
      "control_cells": 4976,
      "target_gene_in_expression_panel": true,
      "target_gene_delta": -0.1646775037499457,
      "cell_level_fdr_lt_0_05": 333,
      "cell_level_fdr_lt_0_05_abs_delta_ge_0_1": 204,
      "inferential_unit": "cell_exploratory_no_biological_replicate_column",
      "reactome_pathways_tested": 1378,
      "camera_fdr_lt_0_05": 64,
      "robust_camera_pathways": 64,
      "robust_camera_pathways_up": 15,
      "robust_camera_pathways_down": 49,
      "camera_supported_pathways_gse233606": 64,
      "camera_supported_pathways_gse272233": 64,
      "camera_supported_pathways_gse277637": 64,
      "projected_reversal_pathways_gse233606": 18,
      "projected_reversal_pathways_gse272233": 52,
      "projected_reversal_pathways_gse277637": 59,
      "k_sources": 3,
      "pooled_rescue_spearman": 0.2576511276403243,
      "pooled_se_fisher_z": 0.015750473013495386,
      "cochran_q": 2.2864894044344455,
      "heterogeneity_pvalue": 0.3187829860498373,
      "i2_percent": 12.529662454539453,
      "source_direction_consistent": true,
      "rescue_spearman_gse233606": 0.2846088151976906,
      "n_pathways_gse233606": 1360,
      "rescue_spearman_gse277637": 0.23042626945287076,
      "n_pathways_gse277637": 1360,
      "rescue_spearman_gse272233": 0.25750890567112344,
      "n_pathways_gse272233": 1320,
      "correction_alignment_spearman": -0.10063474924888087,
      "correction_alignment_n_pathways": 1320,
      "heterogeneity_boundary": "pathways_and_sources_are_not_independent_exploratory_fisher_z_Q_I2",
      "cascade_k_sources": 3,
      "cascade_pooled_rescue_spearman": 0.2394879921083333,
      "cascade_pooled_se_fisher_z": 0.015750473013495386,
      "cascade_cochran_q": 3.1294719207594817,
      "cascade_heterogeneity_pvalue": 0.20914322798200974,
      "cascade_i2_percent": 36.091454065047934,
      "cascade_source_direction_consistent": true,
      "cascade_rescue_spearman_gse233606": 0.27591200750166456,
      "cascade_n_pathways_gse233606": 1360,
      "cascade_rescue_spearman_gse277637": 0.21853641059991807,
      "cascade_n_pathways_gse277637": 1360,
      "cascade_rescue_spearman_gse272233": 0.222997922223729,
      "cascade_n_pathways_gse272233": 1320,
      "cascade_correction_alignment_spearman": -0.0908948135415153,
      "cascade_correction_alignment_n_pathways": 1320,
      "cascade_heterogeneity_boundary": "pathways_and_sources_are_not_independent_exploratory_fisher_z_Q_I2",
      "decision_state": "ABSTAIN_OR_VALIDATE_IN_DMD_PERTURB_SEQ",
      "abstention_reasons": "moderate_dependency_caution;correction_alignment_not_positive",
      "claim_level": "L2_CROSS_CONTEXT_NETWORK_HYPOTHESIS_ONLY",
      "measured_candidate_dmd_perturbation": 0,
      "candidate_level_validated_dmd_pathway_prediction": 0,
      "current_claim": "source_context_effect_and_cross_context_projection_only"
    },
    {
      "candidate": "NAGLU",
      "candidate_cells": 88,
      "control_cells": 4976,
      "target_gene_in_expression_panel": true,
      "target_gene_delta": -0.16255294184685834,
      "cell_level_fdr_lt_0_05": 7,
      "cell_level_fdr_lt_0_05_abs_delta_ge_0_1": 2,
      "inferential_unit": "cell_exploratory_no_biological_replicate_column",
      "reactome_pathways_tested": 1378,
      "camera_fdr_lt_0_05": 0,
      "robust_camera_pathways": 0,
      "robust_camera_pathways_up": 0,
      "robust_camera_pathways_down": 0,
      "camera_supported_pathways_gse233606": 0,
      "camera_supported_pathways_gse272233": 0,
      "camera_supported_pathways_gse277637": 0,
      "projected_reversal_pathways_gse233606": 0,
      "projected_reversal_pathways_gse272233": 0,
      "projected_reversal_pathways_gse277637": 0,
      "k_sources": 3,
      "pooled_rescue_spearman": -0.08151657307871102,
      "pooled_se_fisher_z": 0.015750473013495386,
      "cochran_q": 49.89600024957432,
      "heterogeneity_pvalue": 1.4629221355201276e-11,
      "i2_percent": 95.99166267837859,
      "source_direction_consistent": false,
      "rescue_spearman_gse233606": -0.22309295179703162,
      "n_pathways_gse233606": 1360,
      "rescue_spearman_gse277637": 0.04150672400514176,
      "n_pathways_gse277637": 1360,
      "rescue_spearman_gse272233": -0.05897925487145735,
      "n_pathways_gse272233": 1320,
      "correction_alignment_spearman": 0.18746648451816117,
      "correction_alignment_n_pathways": 1320,
      "heterogeneity_boundary": "pathways_and_sources_are_not_independent_exploratory_fisher_z_Q_I2",
      "cascade_k_sources": 3,
      "cascade_pooled_rescue_spearman": -0.08515985905154713,
      "cascade_pooled_se_fisher_z": 0.015750473013495386,
      "cascade_cochran_q": 23.64251618718759,
      "cascade_heterogeneity_pvalue": 7.3467090479007185e-06,
      "cascade_i2_percent": 91.5406635056727,
      "cascade_source_direction_consistent": true,
      "cascade_rescue_spearman_gse233606": -0.18766750301802965,
      "cascade_n_pathways_gse233606": 1360,
      "cascade_rescue_spearman_gse277637": -0.010742907943897543,
      "cascade_n_pathways_gse277637": 1360,
      "cascade_rescue_spearman_gse272233": -0.05447515896461777,
      "cascade_n_pathways_gse272233": 1320,
      "cascade_correction_alignment_spearman": 0.14119501402666143,
      "cascade_correction_alignment_n_pathways": 1320,
      "cascade_heterogeneity_boundary": "pathways_and_sources_are_not_independent_exploratory_fisher_z_Q_I2",
      "decision_state": "ABSTAIN_OR_VALIDATE_IN_DMD_PERTURB_SEQ",
      "abstention_reasons": "weak_split_half_measurement;moderate_dependency_caution;disease_source_projection_inconsistent",
      "claim_level": "L2_CROSS_CONTEXT_NETWORK_HYPOTHESIS_ONLY",
      "measured_candidate_dmd_perturbation": 0,
      "candidate_level_validated_dmd_pathway_prediction": 0,
      "current_claim": "source_context_effect_and_cross_context_projection_only"
    },
    {
      "candidate": "RAC3",
      "candidate_cells": 92,
      "control_cells": 4976,
      "target_gene_in_expression_panel": true,
      "target_gene_delta": -0.6546756268885031,
      "cell_level_fdr_lt_0_05": 643,
      "cell_level_fdr_lt_0_05_abs_delta_ge_0_1": 522,
      "inferential_unit": "cell_exploratory_no_biological_replicate_column",
      "reactome_pathways_tested": 1378,
      "camera_fdr_lt_0_05": 92,
      "robust_camera_pathways": 92,
      "robust_camera_pathways_up": 22,
      "robust_camera_pathways_down": 70,
      "camera_supported_pathways_gse233606": 92,
      "camera_supported_pathways_gse272233": 92,
      "camera_supported_pathways_gse277637": 92,
      "projected_reversal_pathways_gse233606": 41,
      "projected_reversal_pathways_gse272233": 49,
      "projected_reversal_pathways_gse277637": 29,
      "k_sources": 3,
      "pooled_rescue_spearman": 0.008609781168313594,
      "pooled_se_fisher_z": 0.015750473013495386,
      "cochran_q": 146.0531568449175,
      "heterogeneity_pvalue": 1.9273472071470598e-32,
      "i2_percent": 98.63063555543435,
      "source_direction_consistent": false,
      "rescue_spearman_gse233606": 0.07544077227593962,
      "n_pathways_gse233606": 1360,
      "rescue_spearman_gse277637": -0.2432886969440328,
      "n_pathways_gse277637": 1360,
      "rescue_spearman_gse272233": 0.201485165251438,
      "n_pathways_gse272233": 1320,
      "correction_alignment_spearman": 0.37924763195610073,
      "correction_alignment_n_pathways": 1320,
      "heterogeneity_boundary": "pathways_and_sources_are_not_independent_exploratory_fisher_z_Q_I2",
      "cascade_k_sources": 3,
      "cascade_pooled_rescue_spearman": -0.050613221958265106,
      "cascade_pooled_se_fisher_z": 0.015750473013495386,
      "cascade_cochran_q": 102.47087377139738,
      "cascade_heterogeneity_pvalue": 5.607024872835162e-23,
      "cascade_i2_percent": 98.0482258749332,
      "cascade_source_direction_consistent": false,
      "cascade_rescue_spearman_gse233606": 0.06110368776458697,
      "cascade_n_pathways_gse233606": 1360,
      "cascade_rescue_spearman_gse277637": -0.26777000884745616,
      "cascade_n_pathways_gse277637": 1360,
      "cascade_rescue_spearman_gse272233": 0.06462110754514352,
      "cascade_n_pathways_gse272233": 1320,
      "cascade_correction_alignment_spearman": 0.3832020715002153,
      "cascade_correction_alignment_n_pathways": 1320,
      "cascade_heterogeneity_boundary": "pathways_and_sources_are_not_independent_exploratory_fisher_z_Q_I2",
      "decision_state": "ABSTAIN_OR_VALIDATE_IN_DMD_PERTURB_SEQ",
      "abstention_reasons": "skeletal_muscle_tpm_le_1;moderate_dependency_caution",
      "claim_level": "L2_CROSS_CONTEXT_NETWORK_HYPOTHESIS_ONLY",
      "measured_candidate_dmd_perturbation": 0,
      "candidate_level_validated_dmd_pathway_prediction": 0,
      "current_claim": "source_context_effect_and_cross_context_projection_only"
    },
    {
      "candidate": "RNASEH2C",
      "candidate_cells": 132,
      "control_cells": 4976,
      "target_gene_in_expression_panel": true,
      "target_gene_delta": -0.3664008534131739,
      "cell_level_fdr_lt_0_05": 151,
      "cell_level_fdr_lt_0_05_abs_delta_ge_0_1": 56,
      "inferential_unit": "cell_exploratory_no_biological_replicate_column",
      "reactome_pathways_tested": 1378,
      "camera_fdr_lt_0_05": 61,
      "robust_camera_pathways": 54,
      "robust_camera_pathways_up": 40,
      "robust_camera_pathways_down": 14,
      "camera_supported_pathways_gse233606": 54,
      "camera_supported_pathways_gse272233": 54,
      "camera_supported_pathways_gse277637": 54,
      "projected_reversal_pathways_gse233606": 42,
      "projected_reversal_pathways_gse272233": 10,
      "projected_reversal_pathways_gse277637": 7,
      "k_sources": 3,
      "pooled_rescue_spearman": -0.0865718325924596,
      "pooled_se_fisher_z": 0.015750473013495386,
      "cochran_q": 37.59503590872481,
      "heterogeneity_pvalue": 6.86027742981473e-09,
      "i2_percent": 94.68014871735805,
      "source_direction_consistent": false,
      "rescue_spearman_gse233606": -0.12452074924743554,
      "n_pathways_gse233606": 1360,
      "rescue_spearman_gse277637": 0.04469144658012682,
      "n_pathways_gse277637": 1360,
      "rescue_spearman_gse272233": -0.1807390884335209,
      "n_pathways_gse272233": 1320,
      "correction_alignment_spearman": -0.2474312021823145,
      "correction_alignment_n_pathways": 1320,
      "heterogeneity_boundary": "pathways_and_sources_are_not_independent_exploratory_fisher_z_Q_I2",
      "cascade_k_sources": 3,
      "cascade_pooled_rescue_spearman": -0.1376805141972356,
      "cascade_pooled_se_fisher_z": 0.015750473013495386,
      "cascade_cochran_q": 28.600157587837728,
      "cascade_heterogeneity_pvalue": 6.159630900741621e-07,
      "cascade_i2_percent": 93.00703153869857,
      "cascade_source_direction_consistent": true,
      "cascade_rescue_spearman_gse233606": -0.1822465431749761,
      "cascade_n_pathways_gse233606": 1360,
      "cascade_rescue_spearman_gse277637": -0.021392144663261524,
      "cascade_n_pathways_gse277637": 1360,
      "cascade_rescue_spearman_gse272233": -0.20902332474376673,
      "cascade_n_pathways_gse272233": 1320,
      "cascade_correction_alignment_spearman": -0.1431187300007588,
      "cascade_correction_alignment_n_pathways": 1320,
      "cascade_heterogeneity_boundary": "pathways_and_sources_are_not_independent_exploratory_fisher_z_Q_I2",
      "decision_state": "ABSTAIN_OR_VALIDATE_IN_DMD_PERTURB_SEQ",
      "abstention_reasons": "moderate_dependency_caution;disease_source_projection_inconsistent;correction_alignment_not_positive",
      "claim_level": "L2_CROSS_CONTEXT_NETWORK_HYPOTHESIS_ONLY",
      "measured_candidate_dmd_perturbation": 0,
      "candidate_level_validated_dmd_pathway_prediction": 0,
      "current_claim": "source_context_effect_and_cross_context_projection_only"
    },
    {
      "candidate": "RNF8",
      "candidate_cells": 122,
      "control_cells": 4976,
      "target_gene_in_expression_panel": true,
      "target_gene_delta": -0.24077267105797795,
      "cell_level_fdr_lt_0_05": 17,
      "cell_level_fdr_lt_0_05_abs_delta_ge_0_1": 1,
      "inferential_unit": "cell_exploratory_no_biological_replicate_column",
      "reactome_pathways_tested": 1378,
      "camera_fdr_lt_0_05": 0,
      "robust_camera_pathways": 0,
      "robust_camera_pathways_up": 0,
      "robust_camera_pathways_down": 0,
      "camera_supported_pathways_gse233606": 0,
      "camera_supported_pathways_gse272233": 0,
      "camera_supported_pathways_gse277637": 0,
      "projected_reversal_pathways_gse233606": 0,
      "projected_reversal_pathways_gse272233": 0,
      "projected_reversal_pathways_gse277637": 0,
      "k_sources": 3,
      "pooled_rescue_spearman": 0.006320190780264868,
      "pooled_se_fisher_z": 0.015750473013495386,
      "cochran_q": 0.11932889570306188,
      "heterogeneity_pvalue": 0.9420805977218795,
      "i2_percent": 0.0,
      "source_direction_consistent": false,
      "rescue_spearman_gse233606": 0.012540095889065968,
      "n_pathways_gse233606": 1360,
      "rescue_spearman_gse277637": -0.0006549985194833776,
      "n_pathways_gse277637": 1360,
      "rescue_spearman_gse272233": 0.007097875624301492,
      "n_pathways_gse272233": 1320,
      "correction_alignment_spearman": -0.026146970147745318,
      "correction_alignment_n_pathways": 1320,
      "heterogeneity_boundary": "pathways_and_sources_are_not_independent_exploratory_fisher_z_Q_I2",
      "cascade_k_sources": 3,
      "cascade_pooled_rescue_spearman": -0.07242041115278117,
      "cascade_pooled_se_fisher_z": 0.015750473013495386,
      "cascade_cochran_q": 0.9460791306916575,
      "cascade_heterogeneity_pvalue": 0.6231054173086181,
      "cascade_i2_percent": 0.0,
      "cascade_source_direction_consistent": true,
      "cascade_rescue_spearman_gse233606": -0.05690856158333439,
      "cascade_n_pathways_gse233606": 1360,
      "cascade_rescue_spearman_gse277637": -0.09295905177479341,
      "cascade_n_pathways_gse277637": 1360,
      "cascade_rescue_spearman_gse272233": -0.06718755149805446,
      "cascade_n_pathways_gse272233": 1320,
      "cascade_correction_alignment_spearman": 0.08480650188086616,
      "cascade_correction_alignment_n_pathways": 1320,
      "cascade_heterogeneity_boundary": "pathways_and_sources_are_not_independent_exploratory_fisher_z_Q_I2",
      "decision_state": "ABSTAIN_OR_VALIDATE_IN_DMD_PERTURB_SEQ",
      "abstention_reasons": "weak_split_half_measurement;moderate_dependency_caution;disease_source_projection_inconsistent",
      "claim_level": "L2_CROSS_CONTEXT_NETWORK_HYPOTHESIS_ONLY",
      "measured_candidate_dmd_perturbation": 0,
      "candidate_level_validated_dmd_pathway_prediction": 0,
      "current_claim": "source_context_effect_and_cross_context_projection_only"
    },
    {
      "candidate": "WDR4",
      "candidate_cells": 108,
      "control_cells": 4976,
      "target_gene_in_expression_panel": true,
      "target_gene_delta": -0.20316800640195412,
      "cell_level_fdr_lt_0_05": 24,
      "cell_level_fdr_lt_0_05_abs_delta_ge_0_1": 6,
      "inferential_unit": "cell_exploratory_no_biological_replicate_column",
      "reactome_pathways_tested": 1378,
      "camera_fdr_lt_0_05": 40,
      "robust_camera_pathways": 36,
      "robust_camera_pathways_up": 31,
      "robust_camera_pathways_down": 5,
      "camera_supported_pathways_gse233606": 36,
      "camera_supported_pathways_gse272233": 36,
      "camera_supported_pathways_gse277637": 36,
      "projected_reversal_pathways_gse233606": 32,
      "projected_reversal_pathways_gse272233": 2,
      "projected_reversal_pathways_gse277637": 3,
      "k_sources": 3,
      "pooled_rescue_spearman": -0.019438758163780726,
      "pooled_se_fisher_z": 0.015750473013495386,
      "cochran_q": 55.827487642610116,
      "heterogeneity_pvalue": 7.537287638182013e-13,
      "i2_percent": 96.41753536751759,
      "source_direction_consistent": false,
      "rescue_spearman_gse233606": 0.06584582621029231,
      "n_pathways_gse233606": 1360,
      "rescue_spearman_gse277637": -0.18256105577967277,
      "n_pathways_gse277637": 1360,
      "rescue_spearman_gse272233": 0.0627074297535777,
      "n_pathways_gse272233": 1320,
      "correction_alignment_spearman": 0.1773506752332333,
      "correction_alignment_n_pathways": 1320,
      "heterogeneity_boundary": "pathways_and_sources_are_not_independent_exploratory_fisher_z_Q_I2",
      "cascade_k_sources": 3,
      "cascade_pooled_rescue_spearman": -0.08944620441136349,
      "cascade_pooled_se_fisher_z": 0.015750473013495386,
      "cascade_cochran_q": 14.209282908397125,
      "cascade_heterogeneity_pvalue": 0.0008212841104786769,
      "cascade_i2_percent": 85.92469435021187,
      "cascade_source_direction_consistent": true,
      "cascade_rescue_spearman_gse233606": -0.086354539502391,
      "cascade_n_pathways_gse233606": 1360,
      "cascade_rescue_spearman_gse277637": -0.16160153693858736,
      "cascade_n_pathways_gse277637": 1360,
      "cascade_rescue_spearman_gse272233": -0.017322058298552694,
      "cascade_n_pathways_gse272233": 1320,
      "cascade_correction_alignment_spearman": 0.16933974839975302,
      "cascade_correction_alignment_n_pathways": 1320,
      "cascade_heterogeneity_boundary": "pathways_and_sources_are_not_independent_exploratory_fisher_z_Q_I2",
      "decision_state": "ABSTAIN_OR_VALIDATE_IN_DMD_PERTURB_SEQ",
      "abstention_reasons": "weak_split_half_measurement;moderate_dependency_caution;disease_source_projection_inconsistent",
      "claim_level": "L2_CROSS_CONTEXT_NETWORK_HYPOTHESIS_ONLY",
      "measured_candidate_dmd_perturbation": 0,
      "candidate_level_validated_dmd_pathway_prediction": 0,
      "current_claim": "source_context_effect_and_cross_context_projection_only"
    },
    {
      "candidate": "ZNF236",
      "candidate_cells": 202,
      "control_cells": 4976,
      "target_gene_in_expression_panel": true,
      "target_gene_delta": -0.03604086213874006,
      "cell_level_fdr_lt_0_05": 2966,
      "cell_level_fdr_lt_0_05_abs_delta_ge_0_1": 1366,
      "inferential_unit": "cell_exploratory_no_biological_replicate_column",
      "reactome_pathways_tested": 1378,
      "camera_fdr_lt_0_05": 360,
      "robust_camera_pathways": 352,
      "robust_camera_pathways_up": 77,
      "robust_camera_pathways_down": 275,
      "camera_supported_pathways_gse233606": 352,
      "camera_supported_pathways_gse272233": 352,
      "camera_supported_pathways_gse277637": 352,
      "projected_reversal_pathways_gse233606": 235,
      "projected_reversal_pathways_gse272233": 249,
      "projected_reversal_pathways_gse277637": 185,
      "k_sources": 3,
      "pooled_rescue_spearman": 0.1351847046893013,
      "pooled_se_fisher_z": 0.015750473013495386,
      "cochran_q": 137.3065922577021,
      "heterogeneity_pvalue": 1.5284538378901403e-30,
      "i2_percent": 98.54340569734167,
      "source_direction_consistent": false,
      "rescue_spearman_gse233606": 0.19116773770913298,
      "n_pathways_gse233606": 1360,
      "rescue_spearman_gse277637": -0.1103911973129783,
      "n_pathways_gse277637": 1360,
      "rescue_spearman_gse272233": 0.31950555419500587,
      "n_pathways_gse272233": 1320,
      "correction_alignment_spearman": 0.26092212533511305,
      "correction_alignment_n_pathways": 1320,
      "heterogeneity_boundary": "pathways_and_sources_are_not_independent_exploratory_fisher_z_Q_I2",
      "cascade_k_sources": 3,
      "cascade_pooled_rescue_spearman": 0.045323683368168444,
      "cascade_pooled_se_fisher_z": 0.015750473013495386,
      "cascade_cochran_q": 87.05112523435147,
      "cascade_heterogeneity_pvalue": 1.2505133533799802e-19,
      "cascade_i2_percent": 97.70249954309519,
      "cascade_source_direction_consistent": false,
      "cascade_rescue_spearman_gse233606": 0.0744592309482541,
      "cascade_n_pathways_gse233606": 1360,
      "cascade_rescue_spearman_gse277637": -0.14442327809577876,
      "cascade_n_pathways_gse277637": 1360,
      "cascade_rescue_spearman_gse272233": 0.208701970370529,
      "cascade_n_pathways_gse272233": 1320,
      "cascade_correction_alignment_spearman": 0.14808066858781574,
      "cascade_correction_alignment_n_pathways": 1320,
      "cascade_heterogeneity_boundary": "pathways_and_sources_are_not_independent_exploratory_fisher_z_Q_I2",
      "decision_state": "ABSTAIN_OR_VALIDATE_IN_DMD_PERTURB_SEQ",
      "abstention_reasons": "moderate_dependency_caution",
      "claim_level": "L2_CROSS_CONTEXT_NETWORK_HYPOTHESIS_ONLY",
      "measured_candidate_dmd_perturbation": 0,
      "candidate_level_validated_dmd_pathway_prediction": 0,
      "current_claim": "source_context_effect_and_cross_context_projection_only"
    },
    {
      "candidate": "MON1A",
      "candidate_cells": 94,
      "control_cells": 4976,
      "target_gene_in_expression_panel": true,
      "target_gene_delta": -0.06492278357696818,
      "cell_level_fdr_lt_0_05": 49,
      "cell_level_fdr_lt_0_05_abs_delta_ge_0_1": 18,
      "inferential_unit": "cell_exploratory_no_biological_replicate_column",
      "reactome_pathways_tested": 1378,
      "camera_fdr_lt_0_05": 114,
      "robust_camera_pathways": 113,
      "robust_camera_pathways_up": 97,
      "robust_camera_pathways_down": 16,
      "camera_supported_pathways_gse233606": 113,
      "camera_supported_pathways_gse272233": 113,
      "camera_supported_pathways_gse277637": 113,
      "projected_reversal_pathways_gse233606": 55,
      "projected_reversal_pathways_gse272233": 13,
      "projected_reversal_pathways_gse277637": 55,
      "k_sources": 3,
      "pooled_rescue_spearman": -0.12192493459181579,
      "pooled_se_fisher_z": 0.015750473013495386,
      "cochran_q": 144.16997997895277,
      "heterogeneity_pvalue": 4.941816550269801e-32,
      "i2_percent": 98.61274864552803,
      "source_direction_consistent": false,
      "rescue_spearman_gse233606": -0.1807513666403152,
      "n_pathways_gse233606": 1360,
      "rescue_spearman_gse277637": 0.13007247608243339,
      "n_pathways_gse277637": 1360,
      "rescue_spearman_gse272233": -0.3108837780353263,
      "n_pathways_gse272233": 1320,
      "correction_alignment_spearman": -0.38252019122295633,
      "correction_alignment_n_pathways": 1320,
      "heterogeneity_boundary": "pathways_and_sources_are_not_independent_exploratory_fisher_z_Q_I2",
      "cascade_k_sources": 3,
      "cascade_pooled_rescue_spearman": -0.04679705366014603,
      "cascade_pooled_se_fisher_z": 0.015750473013495386,
      "cascade_cochran_q": 172.99303592413975,
      "cascade_heterogeneity_pvalue": 2.722949238340478e-38,
      "cascade_i2_percent": 98.84388409665402,
      "cascade_source_direction_consistent": false,
      "cascade_rescue_spearman_gse233606": -0.08923446140115791,
      "cascade_n_pathways_gse233606": 1360,
      "cascade_rescue_spearman_gse277637": 0.21906535771751182,
      "cascade_n_pathways_gse277637": 1360,
      "cascade_rescue_spearman_gse272233": -0.27344716741026076,
      "cascade_n_pathways_gse272233": 1320,
      "cascade_correction_alignment_spearman": -0.2986633063937946,
      "cascade_correction_alignment_n_pathways": 1320,
      "cascade_heterogeneity_boundary": "pathways_and_sources_are_not_independent_exploratory_fisher_z_Q_I2",
      "decision_state": "ABSTAIN_OR_VALIDATE_IN_DMD_PERTURB_SEQ",
      "abstention_reasons": "disease_source_projection_inconsistent;correction_alignment_not_positive",
      "claim_level": "L2_CROSS_CONTEXT_NETWORK_HYPOTHESIS_ONLY",
      "measured_candidate_dmd_perturbation": 0,
      "candidate_level_validated_dmd_pathway_prediction": 0,
      "current_claim": "source_context_effect_and_cross_context_projection_only"
    },
    {
      "candidate": "ZNF133",
      "candidate_cells": 84,
      "control_cells": 4976,
      "target_gene_in_expression_panel": false,
      "target_gene_delta": null,
      "cell_level_fdr_lt_0_05": 26,
      "cell_level_fdr_lt_0_05_abs_delta_ge_0_1": 2,
      "inferential_unit": "cell_exploratory_no_biological_replicate_column",
      "reactome_pathways_tested": 1378,
      "camera_fdr_lt_0_05": 0,
      "robust_camera_pathways": 0,
      "robust_camera_pathways_up": 0,
      "robust_camera_pathways_down": 0,
      "camera_supported_pathways_gse233606": 0,
      "camera_supported_pathways_gse272233": 0,
      "camera_supported_pathways_gse277637": 0,
      "projected_reversal_pathways_gse233606": 0,
      "projected_reversal_pathways_gse272233": 0,
      "projected_reversal_pathways_gse277637": 0,
      "k_sources": 3,
      "pooled_rescue_spearman": -0.03822746261761357,
      "pooled_se_fisher_z": 0.015750473013495386,
      "cochran_q": 0.5951896176227366,
      "heterogeneity_pvalue": 0.7426021746536603,
      "i2_percent": 0.0,
      "source_direction_consistent": true,
      "rescue_spearman_gse233606": -0.021200784790329618,
      "n_pathways_gse233606": 1360,
      "rescue_spearman_gse277637": -0.04624065142645514,
      "n_pathways_gse277637": 1360,
      "rescue_spearman_gse272233": -0.047498709207570135,
      "n_pathways_gse272233": 1320,
      "correction_alignment_spearman": -0.15228301712959624,
      "correction_alignment_n_pathways": 1320,
      "heterogeneity_boundary": "pathways_and_sources_are_not_independent_exploratory_fisher_z_Q_I2",
      "cascade_k_sources": 3,
      "cascade_pooled_rescue_spearman": -0.0718077656457758,
      "cascade_pooled_se_fisher_z": 0.015750473013495386,
      "cascade_cochran_q": 10.55420850954244,
      "cascade_heterogeneity_pvalue": 0.005107198546376786,
      "cascade_i2_percent": 81.05021330408881,
      "cascade_source_direction_consistent": true,
      "cascade_rescue_spearman_gse233606": -0.007994165540419642,
      "cascade_n_pathways_gse233606": 1360,
      "cascade_rescue_spearman_gse277637": -0.1318108233204808,
      "cascade_n_pathways_gse277637": 1360,
      "cascade_rescue_spearman_gse272233": -0.07517585258758422,
      "cascade_n_pathways_gse272233": 1320,
      "cascade_correction_alignment_spearman": -0.10483291891757043,
      "cascade_correction_alignment_n_pathways": 1320,
      "cascade_heterogeneity_boundary": "pathways_and_sources_are_not_independent_exploratory_fisher_z_Q_I2",
      "decision_state": "ABSTAIN_OR_VALIDATE_IN_DMD_PERTURB_SEQ",
      "abstention_reasons": "weak_split_half_measurement;disease_source_projection_inconsistent;correction_alignment_not_positive;target_engagement_coordinate_missing_or_not_suppressed",
      "claim_level": "L2_CROSS_CONTEXT_NETWORK_HYPOTHESIS_ONLY",
      "measured_candidate_dmd_perturbation": 0,
      "candidate_level_validated_dmd_pathway_prediction": 0,
      "current_claim": "source_context_effect_and_cross_context_projection_only"
    },
    {
      "candidate": "ADAM10",
      "candidate_cells": 161,
      "control_cells": 4976,
      "target_gene_in_expression_panel": true,
      "target_gene_delta": -0.30043965490279556,
      "cell_level_fdr_lt_0_05": 592,
      "cell_level_fdr_lt_0_05_abs_delta_ge_0_1": 415,
      "inferential_unit": "cell_exploratory_no_biological_replicate_column",
      "reactome_pathways_tested": 1378,
      "camera_fdr_lt_0_05": 342,
      "robust_camera_pathways": 331,
      "robust_camera_pathways_up": 93,
      "robust_camera_pathways_down": 238,
      "camera_supported_pathways_gse233606": 331,
      "camera_supported_pathways_gse272233": 331,
      "camera_supported_pathways_gse277637": 331,
      "projected_reversal_pathways_gse233606": 222,
      "projected_reversal_pathways_gse272233": 241,
      "projected_reversal_pathways_gse277637": 195,
      "k_sources": 3,
      "pooled_rescue_spearman": 0.18083994896842007,
      "pooled_se_fisher_z": 0.015750473013495386,
      "cochran_q": 84.39593890298448,
      "heterogeneity_pvalue": 4.716878826979735e-19,
      "i2_percent": 97.63021772611707,
      "source_direction_consistent": true,
      "rescue_spearman_gse233606": 0.19298929588354455,
      "n_pathways_gse233606": 1360,
      "rescue_spearman_gse277637": 0.0017804292010520535,
      "n_pathways_gse277637": 1360,
      "rescue_spearman_gse272233": 0.3420825014277641,
      "n_pathways_gse272233": 1320,
      "correction_alignment_spearman": 0.21449122104036616,
      "correction_alignment_n_pathways": 1320,
      "heterogeneity_boundary": "pathways_and_sources_are_not_independent_exploratory_fisher_z_Q_I2",
      "cascade_k_sources": 3,
      "cascade_pooled_rescue_spearman": 0.19081168683625013,
      "cascade_pooled_se_fisher_z": 0.015750473013495386,
      "cascade_cochran_q": 49.76328584200195,
      "cascade_heterogeneity_pvalue": 1.5632908239755532e-11,
      "cascade_i2_percent": 95.98097278714677,
      "cascade_source_direction_consistent": true,
      "cascade_rescue_spearman_gse233606": 0.1610488372120406,
      "cascade_n_pathways_gse233606": 1360,
      "cascade_rescue_spearman_gse277637": 0.0768542255987347,
      "cascade_n_pathways_gse277637": 1360,
      "cascade_rescue_spearman_gse272233": 0.3315157074452163,
      "cascade_n_pathways_gse272233": 1320,
      "cascade_correction_alignment_spearman": 0.08210054304243064,
      "cascade_correction_alignment_n_pathways": 1320,
      "cascade_heterogeneity_boundary": "pathways_and_sources_are_not_independent_exploratory_fisher_z_Q_I2",
      "decision_state": "PROVISIONAL_CROSS_CONTEXT_PRIORITY_REQUIRES_DMD_PERTURB_SEQ",
      "abstention_reasons": null,
      "claim_level": "L2_CROSS_CONTEXT_NETWORK_HYPOTHESIS_ONLY",
      "measured_candidate_dmd_perturbation": 0,
      "candidate_level_validated_dmd_pathway_prediction": 0,
      "current_claim": "source_context_effect_and_cross_context_projection_only"
    },
    {
      "candidate": "CALR",
      "candidate_cells": 86,
      "control_cells": 4976,
      "target_gene_in_expression_panel": true,
      "target_gene_delta": -2.161637958159663,
      "cell_level_fdr_lt_0_05": 66,
      "cell_level_fdr_lt_0_05_abs_delta_ge_0_1": 44,
      "inferential_unit": "cell_exploratory_no_biological_replicate_column",
      "reactome_pathways_tested": 1378,
      "camera_fdr_lt_0_05": 15,
      "robust_camera_pathways": 15,
      "robust_camera_pathways_up": 10,
      "robust_camera_pathways_down": 5,
      "camera_supported_pathways_gse233606": 15,
      "camera_supported_pathways_gse272233": 15,
      "camera_supported_pathways_gse277637": 15,
      "projected_reversal_pathways_gse233606": 10,
      "projected_reversal_pathways_gse272233": 12,
      "projected_reversal_pathways_gse277637": 6,
      "k_sources": 3,
      "pooled_rescue_spearman": 0.14707875777020848,
      "pooled_se_fisher_z": 0.015750473013495386,
      "cochran_q": 89.47730884243192,
      "heterogeneity_pvalue": 3.717485276174412e-20,
      "i2_percent": 97.76479643177247,
      "source_direction_consistent": false,
      "rescue_spearman_gse233606": 0.2716495081390536,
      "n_pathways_gse233606": 1360,
      "rescue_spearman_gse277637": -0.058829976619074305,
      "n_pathways_gse277637": 1360,
      "rescue_spearman_gse272233": 0.22321698921419572,
      "n_pathways_gse272233": 1320,
      "correction_alignment_spearman": 0.0950213639962025,
      "correction_alignment_n_pathways": 1320,
      "heterogeneity_boundary": "pathways_and_sources_are_not_independent_exploratory_fisher_z_Q_I2",
      "cascade_k_sources": 3,
      "cascade_pooled_rescue_spearman": 0.11406587455480914,
      "cascade_pooled_se_fisher_z": 0.015750473013495386,
      "cascade_cochran_q": 94.94311803439331,
      "cascade_heterogeneity_pvalue": 2.417485464421209e-21,
      "cascade_i2_percent": 97.89347554471985,
      "cascade_source_direction_consistent": false,
      "cascade_rescue_spearman_gse233606": 0.20665278212484475,
      "cascade_n_pathways_gse233606": 1360,
      "cascade_rescue_spearman_gse277637": -0.09992983102385862,
      "cascade_n_pathways_gse277637": 1360,
      "cascade_rescue_spearman_gse272233": 0.23353185921589867,
      "cascade_n_pathways_gse272233": 1320,
      "cascade_correction_alignment_spearman": 0.12258808147729328,
      "cascade_correction_alignment_n_pathways": 1320,
      "cascade_heterogeneity_boundary": "pathways_and_sources_are_not_independent_exploratory_fisher_z_Q_I2",
      "decision_state": "PROVISIONAL_CROSS_CONTEXT_PRIORITY_REQUIRES_DMD_PERTURB_SEQ",
      "abstention_reasons": null,
      "claim_level": "L2_CROSS_CONTEXT_NETWORK_HYPOTHESIS_ONLY",
      "measured_candidate_dmd_perturbation": 0,
      "candidate_level_validated_dmd_pathway_prediction": 0,
      "current_claim": "source_context_effect_and_cross_context_projection_only"
    },
    {
      "candidate": "DDX19B",
      "candidate_cells": 145,
      "control_cells": 4976,
      "target_gene_in_expression_panel": true,
      "target_gene_delta": -0.14182866042851022,
      "cell_level_fdr_lt_0_05": 6,
      "cell_level_fdr_lt_0_05_abs_delta_ge_0_1": 2,
      "inferential_unit": "cell_exploratory_no_biological_replicate_column",
      "reactome_pathways_tested": 1378,
      "camera_fdr_lt_0_05": 0,
      "robust_camera_pathways": 0,
      "robust_camera_pathways_up": 0,
      "robust_camera_pathways_down": 0,
      "camera_supported_pathways_gse233606": 0,
      "camera_supported_pathways_gse272233": 0,
      "camera_supported_pathways_gse277637": 0,
      "projected_reversal_pathways_gse233606": 0,
      "projected_reversal_pathways_gse272233": 0,
      "projected_reversal_pathways_gse277637": 0,
      "k_sources": 3,
      "pooled_rescue_spearman": -0.017804422609994115,
      "pooled_se_fisher_z": 0.015750473013495386,
      "cochran_q": 47.444308579831535,
      "heterogeneity_pvalue": 4.9842439804149285e-11,
      "i2_percent": 95.78453125387057,
      "source_direction_consistent": false,
      "rescue_spearman_gse233606": -0.0866939103160684,
      "n_pathways_gse233606": 1360,
      "rescue_spearman_gse277637": 0.13339990376779104,
      "n_pathways_gse277637": 1360,
      "rescue_spearman_gse272233": -0.10285937433948046,
      "n_pathways_gse272233": 1320,
      "correction_alignment_spearman": -0.22590124476364382,
      "correction_alignment_n_pathways": 1320,
      "heterogeneity_boundary": "pathways_and_sources_are_not_independent_exploratory_fisher_z_Q_I2",
      "cascade_k_sources": 3,
      "cascade_pooled_rescue_spearman": 0.03239523391654625,
      "cascade_pooled_se_fisher_z": 0.015750473013495386,
      "cascade_cochran_q": 55.0661975438728,
      "cascade_heterogeneity_pvalue": 1.1028771367474012e-12,
      "cascade_i2_percent": 96.36800779932817,
      "cascade_source_direction_consistent": false,
      "cascade_rescue_spearman_gse233606": -0.07588220692283874,
      "cascade_n_pathways_gse233606": 1360,
      "cascade_rescue_spearman_gse277637": 0.19114968469269356,
      "cascade_n_pathways_gse277637": 1360,
      "cascade_rescue_spearman_gse272233": -0.02187887578484578,
      "cascade_n_pathways_gse272233": 1320,
      "cascade_correction_alignment_spearman": -0.22096385819229497,
      "cascade_correction_alignment_n_pathways": 1320,
      "cascade_heterogeneity_boundary": "pathways_and_sources_are_not_independent_exploratory_fisher_z_Q_I2",
      "decision_state": "ABSTAIN_OR_VALIDATE_IN_DMD_PERTURB_SEQ",
      "abstention_reasons": "weak_split_half_measurement;disease_source_projection_inconsistent;correction_alignment_not_positive",
      "claim_level": "L2_CROSS_CONTEXT_NETWORK_HYPOTHESIS_ONLY",
      "measured_candidate_dmd_perturbation": 0,
      "candidate_level_validated_dmd_pathway_prediction": 0,
      "current_claim": "source_context_effect_and_cross_context_projection_only"
    },
    {
      "candidate": "DNM1",
      "candidate_cells": 116,
      "control_cells": 4976,
      "target_gene_in_expression_panel": false,
      "target_gene_delta": null,
      "cell_level_fdr_lt_0_05": 25,
      "cell_level_fdr_lt_0_05_abs_delta_ge_0_1": 5,
      "inferential_unit": "cell_exploratory_no_biological_replicate_column",
      "reactome_pathways_tested": 1378,
      "camera_fdr_lt_0_05": 50,
      "robust_camera_pathways": 49,
      "robust_camera_pathways_up": 49,
      "robust_camera_pathways_down": 0,
      "camera_supported_pathways_gse233606": 49,
      "camera_supported_pathways_gse272233": 49,
      "camera_supported_pathways_gse277637": 49,
      "projected_reversal_pathways_gse233606": 49,
      "projected_reversal_pathways_gse272233": 9,
      "projected_reversal_pathways_gse277637": 11,
      "k_sources": 3,
      "pooled_rescue_spearman": -0.04427144788033064,
      "pooled_se_fisher_z": 0.015750473013495386,
      "cochran_q": 15.561878569353004,
      "heterogeneity_pvalue": 0.0004176197265199018,
      "i2_percent": 87.14808118385703,
      "source_direction_consistent": false,
      "rescue_spearman_gse233606": -0.02789841260922683,
      "n_pathways_gse233606": 1360,
      "rescue_spearman_gse277637": 0.02119097902719678,
      "n_pathways_gse277637": 1360,
      "rescue_spearman_gse272233": -0.12797133415242926,
      "n_pathways_gse272233": 1320,
      "correction_alignment_spearman": -0.2581982929996381,
      "correction_alignment_n_pathways": 1320,
      "heterogeneity_boundary": "pathways_and_sources_are_not_independent_exploratory_fisher_z_Q_I2",
      "cascade_k_sources": 3,
      "cascade_pooled_rescue_spearman": 0.02053463303065301,
      "cascade_pooled_se_fisher_z": 0.015750473013495386,
      "cascade_cochran_q": 18.281719932561415,
      "cascade_heterogeneity_pvalue": 0.00010719510568635441,
      "cascade_i2_percent": 89.06011027749192,
      "cascade_source_direction_consistent": false,
      "cascade_rescue_spearman_gse233606": 0.06413661861250348,
      "cascade_n_pathways_gse233606": 1360,
      "cascade_rescue_spearman_gse277637": 0.0704876052559995,
      "cascade_n_pathways_gse277637": 1360,
      "cascade_rescue_spearman_gse272233": -0.0759180680185973,
      "cascade_n_pathways_gse272233": 1320,
      "cascade_correction_alignment_spearman": -0.2073099549360061,
      "cascade_correction_alignment_n_pathways": 1320,
      "cascade_heterogeneity_boundary": "pathways_and_sources_are_not_independent_exploratory_fisher_z_Q_I2",
      "decision_state": "ABSTAIN_OR_VALIDATE_IN_DMD_PERTURB_SEQ",
      "abstention_reasons": "correction_alignment_not_positive;target_engagement_coordinate_missing_or_not_suppressed",
      "claim_level": "L2_CROSS_CONTEXT_NETWORK_HYPOTHESIS_ONLY",
      "measured_candidate_dmd_perturbation": 0,
      "candidate_level_validated_dmd_pathway_prediction": 0,
      "current_claim": "source_context_effect_and_cross_context_projection_only"
    },
    {
      "candidate": "EHMT2",
      "candidate_cells": 101,
      "control_cells": 4976,
      "target_gene_in_expression_panel": true,
      "target_gene_delta": -0.25494402242493025,
      "cell_level_fdr_lt_0_05": 106,
      "cell_level_fdr_lt_0_05_abs_delta_ge_0_1": 65,
      "inferential_unit": "cell_exploratory_no_biological_replicate_column",
      "reactome_pathways_tested": 1378,
      "camera_fdr_lt_0_05": 21,
      "robust_camera_pathways": 20,
      "robust_camera_pathways_up": 4,
      "robust_camera_pathways_down": 16,
      "camera_supported_pathways_gse233606": 20,
      "camera_supported_pathways_gse272233": 20,
      "camera_supported_pathways_gse277637": 20,
      "projected_reversal_pathways_gse233606": 13,
      "projected_reversal_pathways_gse272233": 11,
      "projected_reversal_pathways_gse277637": 6,
      "k_sources": 3,
      "pooled_rescue_spearman": -0.15574584276838047,
      "pooled_se_fisher_z": 0.015750473013495386,
      "cochran_q": 12.308785532884853,
      "heterogeneity_pvalue": 0.002124130437060853,
      "i2_percent": 83.75144327068917,
      "source_direction_consistent": true,
      "rescue_spearman_gse233606": -0.22817429178981277,
      "n_pathways_gse233606": 1360,
      "rescue_spearman_gse277637": -0.10222158496656379,
      "n_pathways_gse277637": 1360,
      "rescue_spearman_gse272233": -0.13477228075240824,
      "n_pathways_gse272233": 1320,
      "correction_alignment_spearman": -0.12551184967583523,
      "correction_alignment_n_pathways": 1320,
      "heterogeneity_boundary": "pathways_and_sources_are_not_independent_exploratory_fisher_z_Q_I2",
      "cascade_k_sources": 3,
      "cascade_pooled_rescue_spearman": -0.1229780939669683,
      "cascade_pooled_se_fisher_z": 0.015750473013495386,
      "cascade_cochran_q": 14.84287546001552,
      "cascade_heterogeneity_pvalue": 0.0005982883497528936,
      "cascade_i2_percent": 86.52552192203122,
      "cascade_source_direction_consistent": true,
      "cascade_rescue_spearman_gse233606": -0.20494092200393477,
      "cascade_n_pathways_gse233606": 1360,
      "cascade_rescue_spearman_gse277637": -0.0700755050435849,
      "cascade_n_pathways_gse277637": 1360,
      "cascade_rescue_spearman_gse272233": -0.09154145957661527,
      "cascade_n_pathways_gse272233": 1320,
      "cascade_correction_alignment_spearman": -0.16228864031705956,
      "cascade_correction_alignment_n_pathways": 1320,
      "cascade_heterogeneity_boundary": "pathways_and_sources_are_not_independent_exploratory_fisher_z_Q_I2",
      "decision_state": "ABSTAIN_OR_VALIDATE_IN_DMD_PERTURB_SEQ",
      "abstention_reasons": "disease_source_projection_inconsistent;correction_alignment_not_positive",
      "claim_level": "L2_CROSS_CONTEXT_NETWORK_HYPOTHESIS_ONLY",
      "measured_candidate_dmd_perturbation": 0,
      "candidate_level_validated_dmd_pathway_prediction": 0,
      "current_claim": "source_context_effect_and_cross_context_projection_only"
    },
    {
      "candidate": "LMO2",
      "candidate_cells": 96,
      "control_cells": 4976,
      "target_gene_in_expression_panel": false,
      "target_gene_delta": null,
      "cell_level_fdr_lt_0_05": 11,
      "cell_level_fdr_lt_0_05_abs_delta_ge_0_1": 4,
      "inferential_unit": "cell_exploratory_no_biological_replicate_column",
      "reactome_pathways_tested": 1378,
      "camera_fdr_lt_0_05": 3,
      "robust_camera_pathways": 3,
      "robust_camera_pathways_up": 3,
      "robust_camera_pathways_down": 0,
      "camera_supported_pathways_gse233606": 3,
      "camera_supported_pathways_gse272233": 3,
      "camera_supported_pathways_gse277637": 3,
      "projected_reversal_pathways_gse233606": 3,
      "projected_reversal_pathways_gse272233": 0,
      "projected_reversal_pathways_gse277637": 0,
      "k_sources": 3,
      "pooled_rescue_spearman": -0.08239163562543395,
      "pooled_se_fisher_z": 0.015750473013495386,
      "cochran_q": 17.698922497871063,
      "heterogeneity_pvalue": 0.00014345900415154328,
      "i2_percent": 88.69987706742842,
      "source_direction_consistent": false,
      "rescue_spearman_gse233606": -0.10149923396660987,
      "n_pathways_gse233606": 1360,
      "rescue_spearman_gse277637": 0.005610349277627174,
      "n_pathways_gse277637": 1360,
      "rescue_spearman_gse272233": -0.15239370054971907,
      "n_pathways_gse272233": 1320,
      "correction_alignment_spearman": -0.026680010417149513,
      "correction_alignment_n_pathways": 1320,
      "heterogeneity_boundary": "pathways_and_sources_are_not_independent_exploratory_fisher_z_Q_I2",
      "cascade_k_sources": 3,
      "cascade_pooled_rescue_spearman": -0.0954402915855435,
      "cascade_pooled_se_fisher_z": 0.015750473013495386,
      "cascade_cochran_q": 29.623231643180958,
      "cascade_heterogeneity_pvalue": 3.693150284143727e-07,
      "cascade_i2_percent": 93.24854214391432,
      "cascade_source_direction_consistent": false,
      "cascade_rescue_spearman_gse233606": -0.1508552603969646,
      "cascade_n_pathways_gse233606": 1360,
      "cascade_rescue_spearman_gse277637": 0.02447601071741253,
      "cascade_n_pathways_gse277637": 1360,
      "cascade_rescue_spearman_gse272233": -0.16020984160834376,
      "cascade_n_pathways_gse272233": 1320,
      "cascade_correction_alignment_spearman": -0.08546825754976944,
      "cascade_correction_alignment_n_pathways": 1320,
      "cascade_heterogeneity_boundary": "pathways_and_sources_are_not_independent_exploratory_fisher_z_Q_I2",
      "decision_state": "ABSTAIN_OR_VALIDATE_IN_DMD_PERTURB_SEQ",
      "abstention_reasons": "weak_split_half_measurement;disease_source_projection_inconsistent;correction_alignment_not_positive;target_engagement_coordinate_missing_or_not_suppressed",
      "claim_level": "L2_CROSS_CONTEXT_NETWORK_HYPOTHESIS_ONLY",
      "measured_candidate_dmd_perturbation": 0,
      "candidate_level_validated_dmd_pathway_prediction": 0,
      "current_claim": "source_context_effect_and_cross_context_projection_only"
    },
    {
      "candidate": "MPHOSPH6",
      "candidate_cells": 83,
      "control_cells": 4976,
      "target_gene_in_expression_panel": true,
      "target_gene_delta": -0.2912822625046622,
      "cell_level_fdr_lt_0_05": 253,
      "cell_level_fdr_lt_0_05_abs_delta_ge_0_1": 181,
      "inferential_unit": "cell_exploratory_no_biological_replicate_column",
      "reactome_pathways_tested": 1378,
      "camera_fdr_lt_0_05": 200,
      "robust_camera_pathways": 190,
      "robust_camera_pathways_up": 39,
      "robust_camera_pathways_down": 151,
      "camera_supported_pathways_gse233606": 190,
      "camera_supported_pathways_gse272233": 190,
      "camera_supported_pathways_gse277637": 190,
      "projected_reversal_pathways_gse233606": 155,
      "projected_reversal_pathways_gse272233": 147,
      "projected_reversal_pathways_gse277637": 93,
      "k_sources": 3,
      "pooled_rescue_spearman": 0.117933634985772,
      "pooled_se_fisher_z": 0.015750473013495386,
      "cochran_q": 183.1231018621388,
      "heterogeneity_pvalue": 1.7191892074915697e-40,
      "i2_percent": 98.90783850881596,
      "source_direction_consistent": false,
      "rescue_spearman_gse233606": 0.22105711651348695,
      "n_pathways_gse233606": 1360,
      "rescue_spearman_gse277637": -0.17463500194800297,
      "n_pathways_gse277637": 1360,
      "rescue_spearman_gse272233": 0.30303744843526575,
      "n_pathways_gse272233": 1320,
      "correction_alignment_spearman": 0.24275502333726962,
      "correction_alignment_n_pathways": 1320,
      "heterogeneity_boundary": "pathways_and_sources_are_not_independent_exploratory_fisher_z_Q_I2",
      "cascade_k_sources": 3,
      "cascade_pooled_rescue_spearman": 0.09279499071646487,
      "cascade_pooled_se_fisher_z": 0.015750473013495386,
      "cascade_cochran_q": 166.10174439247106,
      "cascade_heterogeneity_pvalue": 8.540130122782338e-37,
      "cascade_i2_percent": 98.79591872601029,
      "cascade_source_direction_consistent": false,
      "cascade_rescue_spearman_gse233606": 0.21453317409096131,
      "cascade_n_pathways_gse233606": 1360,
      "cascade_rescue_spearman_gse277637": -0.18871761081650823,
      "cascade_n_pathways_gse277637": 1360,
      "cascade_rescue_spearman_gse272233": 0.2515927825264553,
      "cascade_n_pathways_gse272233": 1320,
      "cascade_correction_alignment_spearman": 0.18850092030160023,
      "cascade_correction_alignment_n_pathways": 1320,
      "cascade_heterogeneity_boundary": "pathways_and_sources_are_not_independent_exploratory_fisher_z_Q_I2",
      "decision_state": "PROVISIONAL_CROSS_CONTEXT_PRIORITY_REQUIRES_DMD_PERTURB_SEQ",
      "abstention_reasons": null,
      "claim_level": "L2_CROSS_CONTEXT_NETWORK_HYPOTHESIS_ONLY",
      "measured_candidate_dmd_perturbation": 0,
      "candidate_level_validated_dmd_pathway_prediction": 0,
      "current_claim": "source_context_effect_and_cross_context_projection_only"
    },
    {
      "candidate": "GFOD2",
      "candidate_cells": 127,
      "control_cells": 4976,
      "target_gene_in_expression_panel": true,
      "target_gene_delta": -0.11266331446347164,
      "cell_level_fdr_lt_0_05": 31,
      "cell_level_fdr_lt_0_05_abs_delta_ge_0_1": 17,
      "inferential_unit": "cell_exploratory_no_biological_replicate_column",
      "reactome_pathways_tested": 1378,
      "camera_fdr_lt_0_05": 35,
      "robust_camera_pathways": 35,
      "robust_camera_pathways_up": 11,
      "robust_camera_pathways_down": 24,
      "camera_supported_pathways_gse233606": 35,
      "camera_supported_pathways_gse272233": 35,
      "camera_supported_pathways_gse277637": 35,
      "projected_reversal_pathways_gse233606": 3,
      "projected_reversal_pathways_gse272233": 26,
      "projected_reversal_pathways_gse277637": 33,
      "k_sources": 3,
      "pooled_rescue_spearman": -0.1604445587128509,
      "pooled_se_fisher_z": 0.015750473013495386,
      "cochran_q": 139.33031002194105,
      "heterogeneity_pvalue": 5.556580337576453e-31,
      "i2_percent": 98.56456215472065,
      "source_direction_consistent": false,
      "rescue_spearman_gse233606": -0.3510066254809401,
      "n_pathways_gse233606": 1360,
      "rescue_spearman_gse277637": 0.08132487025655093,
      "n_pathways_gse277637": 1360,
      "rescue_spearman_gse272233": -0.19892667161198527,
      "n_pathways_gse272233": 1320,
      "correction_alignment_spearman": -0.08545546828041847,
      "correction_alignment_n_pathways": 1320,
      "heterogeneity_boundary": "pathways_and_sources_are_not_independent_exploratory_fisher_z_Q_I2",
      "cascade_k_sources": 3,
      "cascade_pooled_rescue_spearman": -0.1699864557179811,
      "cascade_pooled_se_fisher_z": 0.015750473013495386,
      "cascade_cochran_q": 118.03116164226535,
      "cascade_heterogeneity_pvalue": 2.3434673279285353e-26,
      "cascade_i2_percent": 98.30553222371759,
      "cascade_source_direction_consistent": false,
      "cascade_rescue_spearman_gse233606": -0.3502671086305518,
      "cascade_n_pathways_gse233606": 1360,
      "cascade_rescue_spearman_gse277637": 0.04874363135673191,
      "cascade_n_pathways_gse277637": 1360,
      "cascade_rescue_spearman_gse272233": -0.19621433570770958,
      "cascade_n_pathways_gse272233": 1320,
      "cascade_correction_alignment_spearman": -0.033810114553766965,
      "cascade_correction_alignment_n_pathways": 1320,
      "cascade_heterogeneity_boundary": "pathways_and_sources_are_not_independent_exploratory_fisher_z_Q_I2",
      "decision_state": "ABSTAIN_OR_VALIDATE_IN_DMD_PERTURB_SEQ",
      "abstention_reasons": "disease_source_projection_inconsistent;correction_alignment_not_positive",
      "claim_level": "L2_CROSS_CONTEXT_NETWORK_HYPOTHESIS_ONLY",
      "measured_candidate_dmd_perturbation": 0,
      "candidate_level_validated_dmd_pathway_prediction": 0,
      "current_claim": "source_context_effect_and_cross_context_projection_only"
    }
  ]
}
