{
  "schema": "nmd-vcell-measured-dmd-evidence-api/1.0",
  "object_id": "MDE:v1.2.0-measured-dmd-evidence:EA-20260804-49",
  "resource_release": "v1.2.0-measured-dmd-evidence",
  "interface_build": "EA-20260804-49",
  "evidence_freeze": "2026-08-03",
  "release_state": "RELEASED_MEASURED_DMD_CONTEXT_CANDIDATE_PREDICTION_LOCKED",
  "evidence_chain": [
    "DMD induction",
    "patient-muscle pathway replication",
    "DMD-locus CRISPR correction",
    "organoid heterogeneity"
  ],
  "headline_results": {
    "gse272233_samples": 21,
    "gse272233_biological_repeats_per_group": 3,
    "reactome_pathways_tested": 1559,
    "dual_supported_reversal_all_3_backgrounds": 0,
    "background_specific_dual_supported_reversal": 24,
    "prjna772047_camera_supported_disease_pathways": 291,
    "disease_direction_consistent_all_3_external_datasets": 810,
    "strict_independent_reversal_all_3_backgrounds": 0
  },
  "validation_status": {
    "section": "limitations",
    "stage": "prospective_validation_prespecified",
    "candidate_count": 21,
    "candidate_dmd_response_truth": "0/21",
    "candidate_level_dmd_pathway_predictions": 0,
    "interpretation": "Validation gap; not an observed negative biological effect.",
    "candidate_truth_boundary": "candidate-truth-boundary.json"
  },
  "api": {
    "gse272233_reactome": "gse272233-reactome.json",
    "external_validation": "external-validation.json",
    "sample_qc": "sample-qc.json",
    "statistical_units": "statistical-units.json",
    "candidate_truth_boundary": "candidate-truth-boundary.json",
    "cleanroom_reproducibility": "cleanroom-reproducibility.json",
    "release_manifest": "release-manifest.json"
  },
  "figure": {
    "page": "/resource/measured-dmd-evidence/",
    "pdf": "/resource/downloads/figure8_measured_dmd_evidence_v1.pdf",
    "png": "/resource/downloads/figure8_measured_dmd_evidence_v1.png",
    "source_data": "/resource/downloads/figure8_measured_dmd_evidence_source_data_v1.tsv"
  },
  "cleanroom_reproducibility": {
    "status": "PASS",
    "checks": {
      "checks": 16,
      "passed": 16,
      "failed": 0
    },
    "api": "cleanroom-reproducibility.json",
    "report": "/resource/downloads/CLEANROOM_MEASURED_DMD_REPRODUCIBILITY_REPORT_v1.md",
    "isolation_boundary": "Fresh path-isolated workspace and process environment; system Python/R packages reused, not a container or independently administered host."
  },
  "claim_boundary": {
    "allowed": "Measured DMD-locus induction/correction and sample-level external disease pathway replication with explicit small-n limitations.",
    "blocked": "Candidate-gene response prediction in DMD cells, therapeutic efficacy, patient-level simulation and clinical decision support."
  }
}