{
  "schema": "nmd-vcell-dmd-statistical-units/1.0",
  "resource_release": "v1.2.0-measured-dmd-evidence",
  "records": [
    {
      "dataset": "GSE233606",
      "species": "human",
      "modality": "single-cell RNA-seq",
      "groups": "healthy; patient DMD; engineered DMD",
      "biological_units": "one line per condition",
      "cells_or_samples": "3566 cells",
      "analysis_role": "measured DMD induction and patient-line replication",
      "formal_inference": "no",
      "claim_ceiling": "descriptive unselected gene-axis concordance"
    },
    {
      "dataset": "PRJNA772047",
      "species": "human",
      "modality": "single-nucleus RNA-seq pseudobulk",
      "groups": "3 DMD; 2 Normal",
      "biological_units": "5 reported donors/samples",
      "cells_or_samples": "8776 nuclei; 5 pseudobulks",
      "analysis_role": "independent patient-muscle pathway replication",
      "formal_inference": "yes, small-n camera/limma",
      "claim_ceiling": "sample-level pathway association"
    },
    {
      "dataset": "PRJNA1218493",
      "species": "human",
      "modality": "single-cell/nucleus RNA-seq pseudobulk",
      "groups": "2 DMD; 1 Normal",
      "biological_units": "3 reported samples",
      "cells_or_samples": "7439 cells; 3 pseudobulks",
      "analysis_role": "external disease-direction sensitivity",
      "formal_inference": "no, one control",
      "claim_ceiling": "directional sensitivity only"
    },
    {
      "dataset": "GSE156497",
      "species": "mouse",
      "modality": "single-cell RNA-seq pseudobulk",
      "groups": "1 DMD-like; 1 WT",
      "biological_units": "2 reported samples",
      "cells_or_samples": "11581 cells; 2 pseudobulks",
      "analysis_role": "cross-species disease-direction sensitivity",
      "formal_inference": "no",
      "claim_ceiling": "descriptive direction only"
    },
    {
      "dataset": "GSE272233",
      "species": "human",
      "modality": "bulk RNA-seq",
      "groups": "WT; 3 DMD duplication backgrounds; corrected clones",
      "biological_units": "3 reported biological repeats per group",
      "cells_or_samples": "21 samples",
      "analysis_role": "measured DMD-locus CRISPR correction",
      "formal_inference": "yes, camera/limma",
      "claim_ceiling": "background-specific correction response"
    },
    {
      "dataset": "GSE277637",
      "species": "human",
      "modality": "organoid single-cell RNA-seq pseudobulk",
      "groups": "3 DMD patient lines; 1 WT line",
      "biological_units": "4 lines with one shared WT",
      "cells_or_samples": "10480 cells; 4 pseudobulks",
      "analysis_role": "model-system heterogeneity stress test",
      "formal_inference": "no",
      "claim_ceiling": "line-specific descriptive effects"
    }
  ]
}